L‐689,660, a novel cholinomimetic with functional selectivity for M₁ and M₃ muscarinic receptors

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

The Cholinergic Hypothesis of Geriatric Memory Dysfunction

1982 • 5,422 citations

SOME QUANTITATIVE USES OF DRUG ANTAGONISTS

1959 • 3,948 citations

Muscarinic Receptor Subtypes

1990 • 1,346 citations

Loss of M2 Muscarine Receptors in the Cerebral Cortex in Alzheimer's Disease and Experimental Cholinergic Denervation

1985 • 697 citations

Antagonist binding properties of five cloned muscarinic receptors expressed in CHO-K1 cells.

1989 • 627 citations

THE CHOLINERGIC HYPOTHESIS—TEN YEARS ON

1986 • 563 citations

Localization of a family of muscarinic receptor mRNAs in rat brain

1988 • 472 citations

Presynaptic Cholinergic Dysfunction in Patients with Dementia

1983 • 422 citations

The Cholinergic Hypothesis: A Historical Overview, Current Perspective, and Future Directions

1985 • 386 citations

Differential Alteration of Various Cholinergic Markers in Cortical and Subcortical Regions of Human Brain in Alzheimer's Disease

1988 • 334 citations

Cardiovascular Control by Cholinergic Mechanisms in the Central Nervous System

1982 • 239 citations

Learning impairment following lesion of the basal nucleus of Meynert in the marmoset: Modification by cholinergic drugs

1986 • 197 citations

MUSCARINIC RECEPTOR SUBTYPES: A CRITIQUE OF THE CURRENT CLASSIFICATION AND A PROPOSAL FOR A WORKING NOMENCLATURE

1986 • 185 citations

CHOLINERGIC APPROACHES TO THE TREATMENT OF ALZHEIMER'S DISEASE

1986 • 159 citations

Muscarinic autoreceptor regulates acetylcholine release in rat hippocampus: in vitro evidence

1980 • 144 citations

Memory dysfunctions: an integration of animal and human research from preclinical and clinical perspectives.

1985 • 123 citations

Relative affinities of drugs acting at cholinoceptors in displacing agonist and antagonist radioligands: the NMS/Oxo‐M ratio as an index of efficacy at cortical muscarinic receptors

1988 • 108 citations

Rat hippocampal muscarinic autoreceptors are similar to the M₂ (cardiac) subtype: comparison with hippocampal M₁, atrial M₂ and ileal M₃ receptors

1990 • 101 citations

Learning about rules but not about reward is impaired following lesions of the cholinergic projection to the hippocampus

1989 • 101 citations

Muscarinic receptor subtypes in human neurodegenerative disorders: focus on Alzheimer's disease.

1989 • 98 citations

Effects of ibotenic acid lesions of the basal forebrain on serial reversal learning in marmosets

1985 • 95 citations

The pharmacological assessment of RS 86 (2-ethyl-8-methyl-2,8-diazaspiro-[4,5]-decan-1,3-dion hydrobromide). A potent, specific muscarinic acetylcholine receptor agonist

1986 • 94 citations

The striatum and cerebral cortex express different muscarinic receptor mRNAs

1988 • 90 citations

Frequency-dependent muscarinic receptor modulation of acetylcholine and dopamine release from rabbit striatum.

1984 • 63 citations

Pharmacological differences between two muscarinic responses of the rat superior cervical ganglion in vitro

1987 • 54 citations

Differential modification of muscarinic cholinergic receptors in the hippocampus of patients with Alzheimer's disease: an autoradiographic study

1988 • 53 citations

Drugs and Receptors

1990 • 51 citations

Central pressor effects induced by muscarinic receptor agonists: Evidence for a predominant role of the M2 receptor subtype

1986 • 39 citations

Presynaptic antagonist-postsynaptic agonist at muscarinic cholinergic synapses. N-methyl-N-(1-methyl-4-pyrrolidino-2-butynyl)acetamide.

1983 • 38 citations

Muscarinic Agonists for Senile Dementia: Past Experience and Future Trends

1991 • 30 citations

Selectivity of partial agonists related to oxotremorine based on differences in muscarinic receptor reserve between the guinea pig ileum and urinary bladder.

1987 • 30 citations

A novel series of non‐quaternary oxadiazoles acting as full agonists at muscarinic receptors

1990 • 30 citations

Chapter 27 Cholinergic receptors in the rat and human brain: microscopic visualization

1990 • 23 citations

Synthesis of azabicyclic pyrazine derivatives as muscarinic agonists and the preparation of a chloropyrazine analogue with functional selectivity at sub-types of the muscarinic receptor

1991 • 18 citations

Chapter 12 Cholinergic mechanisms subserving cardiovascular function in the medulla and spinal cord

1989 • 12 citations

Muscarinic and antimuscarinic activity of acetamides related to oxotremorine in the guinea pig urinary bladder.

1987 • 11 citations

Pharmacological properties of cloned muscarinic receptors expressed in A9 L cells; comparison with in vitro models

1991 • 10 citations

Characterization of rat liver β‐adrenoceptors during perinatal development as determined by [¹²⁵I]‐iodopindolol radioligand binding assays

1988 • 10 citations

Stereoselectivity of pesticides: Biological and chemical problems (Chemicals in agriculture, vol. 1)

1989 • 10 citations

Structural requirements for affinity and efficacy of N-(4-amino-2-butynyl) succinimides at muscarinic receptors in the guinea-pig ileum and urinary bladder

1987 • 6 citations

AF102B: A Novel M1 Agonist as a Rational Treatment Strategy in Alzheimer’s Disease

1989 • 1 citations

Deleted Work

1955 • 0 citations