Suppression of Capacitative Ca2+ Entry by Serine/Threonine Phosphatase Inhibitors in Rat Parotid Acinar Cells

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

Thapsigargin, a tumor promoter, discharges intracellular Ca2+ stores by specific inhibition of the endoplasmic reticulum Ca2(+)-ATPase.

1990 • 3,250 citations

Staurosporine, a potent inhibitor of phospholipidCa++dependent protein kinase

1986 • 2,445 citations

Inhibitory effect of a marine-sponge toxin, okadaic acid, on protein phosphatases. Specificity and kinetics

1988 • 1,699 citations

Capacitative calcium entry revisited

1990 • 1,499 citations

Calyculin A and okadaic acid: Inhibitors of protein phosphatase activity

1989 • 1,032 citations

Emptying of intracellular Ca2+ stores releases a novel small messenger that stimulates Ca2+ influx

1993 • 892 citations

Activation of Calcium Entry by the Tumor Promoter Thapsigargin in Parotid Acinar Cells

1989 • 887 citations

Use of Manganese to Discriminate Between Calcium Influx and Mobilization From Internal Stores in Stimulated Human Neutrophils

1989 • 520 citations

Depletion of InsP3 stores activates a Ca2+ and K+ current by means of a phosphatase and a diffusible messenger

1993 • 363 citations

Smooth muscle myosin phosphatase inhibition and force enhancement by black sponge toxin

1987 • 280 citations

Inhibition of bradykinin- and thapsigargin-induced Ca2+ entry by tyrosine kinase inhibitors

1993 • 206 citations

Tautomycin from the bacterium Streptomyces verticillatus

1990 • 191 citations

ADP- and thapsigargin-evoked Ca2+ entry and protein-tyrosine phosphorylation are inhibited by the tyrosine kinase inhibitors genistein and methyl-2,5-dihydroxycinnamate in fura-2-loaded human platelets.

1993 • 191 citations

Replenishing the stores

1995 • 185 citations

Inhibition of thapsigargin-induced calcium entry by microinjected guanine nucleotide analogues. Evidence for the involvement of a small G-protein in capacitative calcium entry.

1993 • 183 citations

The regulation of capacitative calcium entry by calcium and protein kinase C in Xenopus oocytes.

1994 • 153 citations

Structure-activity relationship within a series of okadaic acid derivatives

1990 • 139 citations

Degradation of a Calcium Influx Factor (CIF) Can Be Blocked by Phosphatase Inhibitors or Chelation of Ca2+

1995 • 134 citations

Cyclic GMP modulates depletion-activated Ca2+ entry in pancreatic acinar cells

1993 • 130 citations

Calcium-independent activation of contractile apparatus in smooth muscle by calyculin-A.

1989 • 114 citations

Structurally different members of the okadaic acid class selectively inhibit protein serine/threonine but not tyrosine phosphatase activity

1992 • 100 citations

Refill status of the agonist-sensitive Ca2+ pool regulates Mn2+ influx into parotid acini.

1990 • 78 citations

A novel protein phosphatase inhibitor, tautomycin Effect on smooth muscle

1991 • 71 citations

Staurosporine inhibits a tyrosine protein kinase in human hepatoma cell membranes

1990 • 64 citations

Staurosporine inhibits the soluble and membrane-bound protein tyrosine kinases of human neutrophils

1991 • 60 citations

Modulatory effect of protein kinase C on thapsigargin-induced calcium entry in thyroid FRTL-5 cells

1993 • 55 citations

Phosphorylation down-regulates the store-operated Ca2+ entry pathway of human neutrophils.

1994 • 55 citations

Evidence that isoproterenol-induced Ca2+-mobilization in rat parotid acinar cells is not mediated by activation of β-adrenoceptors

1990 • 34 citations

Phosphatase inhibitors suppress Ca2+ influx induced by receptor-mediated intracellular Ca2+ store depletion in human platelets

1994 • 32 citations

Okadaic acid uncouples calcium entry from depletion of intracellular stores

1993 • 32 citations

Effects of retinoic acid and staurosporine on the protein kinase C activity and the morphology of two related human neuroblastoma cell lines

1990 • 26 citations

Okadaic acid inhibits amylase exocytosis from parotid acini stimulated by cyclic AMP

1991 • 23 citations

Relationship between cytosolic Ca2+ concentration and amylase release in rat parotid acinar cells following muscarinic stimulation

1992 • 22 citations

Elevation of cytosolic [Ca2+] due to intracellular Ca2+ release retards carbachol stimulation of divalent cation entry in rat parotid gland acinar cells

1992 • 18 citations

Protein phosphatase inhibitor calyculin A induces hyperphosphorylation of cytokeratins and inhibits amylase exocytosis in the rat parotid acini

1993 • 17 citations

Effect of Thapsigargin on Cytosolic Ca2+ Level and Amylase Release in Rat Parotid Acinar Cells.

1992 • 14 citations

Regulation by Protein Kinase C of Platelet-Activating Factor- and Thapsigargin-Induced Calcium Entry in Rabbit Neutrophils

1994 • 10 citations

Staurosporine enhances Ca2+ entry induced by depletion of intracellular Ca2+ stores in rat parotid acinar cells

1995 • 10 citations