Null Mutation in Transforming Growth Factor β1 Disrupts Ovarian Function and Causes Oocyte Incompetence and Early Embryo Arrest

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

2001 • 156,143 citations

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

Targeted disruption of the mouse transforming growth factor-β1 gene results in multifocal inflammatory disease

1992 • 2,969 citations

Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death.

1993 • 1,941 citations

The purification, cloning, and expression of a novel luteinizing hormone-induced mitochondrial protein in MA-10 mouse Leydig tumor cells. Characterization of the steroidogenic acute regulatory protein (StAR).

1994 • 1,140 citations

PROPOSAL FOR A CLASSIFICATION OF OOCYTES AND FOLLICLES IN THE MOUSE OVARY

1968 • 1,058 citations

Defective haematopoiesis and vasculogenesis in transforming growth factor-β1 knock out mice

1995 • 1,020 citations

Developmental Expression of PDGF, TGF-α, and TGF-β Genes in Preimplantation Mouse Embryos

1988 • 688 citations

Preimplantation embryo development in vitro: cooperative interactions among embryos and role of growth factors.

1990 • 685 citations

The oestrous cycle in the mouse

1922 • 547 citations

Maternal Rescue of Transforming Growth Factor-β 1 Null Mice

1994 • 494 citations

Modulation of Macrophage Function by Transforming Growth Factor ?, Interleukin-4, and Interleukin-10

1993 • 393 citations

Targeted disruption of luteinizing hormone β-subunit leads to hypogonadism, defects in gonadal steroidogenesis, and infertility

2004 • 315 citations

Early-onset multifocal inflammation in the transforming growth factor beta 1-null mouse is lymphocyte mediated.

1995 • 275 citations

Autoimmunity associated with TGF-beta1-deficiency in mice is dependent on MHC class II antigen expression.

1996 • 236 citations

Immune cells in the corpus luteum: friends or foes?

2001 • 179 citations

Functional regulation of human trophoblast differentiation

1998 • 174 citations

Mapping of a major genetic modifier of embryonic lethality in TGFβ1 knockout mice

1997 • 166 citations

Structural Characterization of Normal and Mutant Human Steroid 17α- Hydroxylase Genes: Molecular Basis of One Example of Combined 17α- Hydroxylase/17,20 Lyase Deficiency

1988 • 154 citations

Absence of Colony Stimulating Factor-1 in Osteopetrotic (csfmop/csfmop) Mice Disrupts Estrous Cycles and Ovulation1

1997 • 138 citations

Defining the actions of transforming growth factor beta in reproduction

2002 • 126 citations

Multiple forms of mouse 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase and differential expression in gonads, adrenal glands, liver, and kidneys of both sexes.

1991 • 120 citations

Transforming growth factor beta and the endometrium

1998 • 104 citations

Gonadotropins and Cytokines Affect Luteal Function through Control of Apoptosis in Human Luteinized Granulosa Cells

2000 • 101 citations

Rat cholesterol side-chain cleavage cytochrome P-450 (P-450scc) gene. Structure and regulation by cAMP in vitro.

1990 • 99 citations

Presence of transforming growth factor-beta and their selective cellular localization in human ovarian tissue of various reproductive stages.

1992 • 97 citations

The developmental competence of mammalian oocytes: a convenient but biologically fuzzy concept

2001 • 94 citations

Intrabursal Injection of Clodronate Liposomes Causes Macrophage Depletion and Inhibits Ovulation in the Mouse Ovary1

2000 • 87 citations

Strain dependency of TGF?1 function during embryogenesis

1999 • 84 citations

Localization and binding of transforming growth factor-β isoforms in mouse preimplantation embryos and in delayed and activated blastocysts

1992 • 81 citations

Effect of macrophages on proliferation of granulosa cells in the ovary in rats

1992 • 70 citations

Beta 2-microglobulin-deficient background ameliorates lethal phenotype of the TGF-beta 1 null mouse.

1999 • 66 citations

Evaluation of members of the TGFbeta superfamily as candidates for the oocyte factors that control mouse cumulus expansion and steroidogenesis.

2003 • 65 citations

Epidermal Growth Factor and Transforming Growth Factor-β Modulation of Follicle-Stimulating Hormone-Induced Deoxyribonucleic Acid Synthesis in Hamster Preantral and Early Antral Follicles1

1993 • 64 citations

Colony-Stimulating Factor 1 Regulation of Neuroendocrine Pathways that Control Gonadal Function in Mice

2002 • 64 citations

Ovarian transforming growth factor-β (TGFβ): cellular site(s), and mechanism(s) of action

1989 • 63 citations

Transforming growth factor‐β1 in reproduction

1994 • 62 citations

Gene transcription and regulation of oocyte maturation.

2004 • 56 citations

Possible Role of Transforming Growth Factor-β as a Mediator of Luteotropic Action of Prolactin in Rat Luteal Cell Cultures

1990 • 54 citations

β2-Microglobulin-Deficient Background Ameliorates Lethal Phenotype of the TGF-β1 Null Mouse

1999 • 54 citations

Comparison of oocyte factors and transforming growth factor-β in the regulation of DNA synthesis in bovine granulosa cells

2003 • 53 citations

Cell-Type-Specific Localization of Transforming Growth Factor-β2 and Transforming Growth Factor-β1 in the Hamster Ovary: Differential Regulation by Follicle-Stimulating Hormone and Luteinizing Hormone1

1992 • 50 citations

Gene transcription and regulation of oocyte maturation

2004 • 48 citations

TGFbeta receptor types I and II and the substrate proteins Smad 2 and 3 are present in human oocytes

2000 • 44 citations

Quantification of transforming growth factor beta1 (TGFbeta1) mRNA expression in mouse preimplantation embryos and determination of TGFbeta receptor (type I and type II) expression in mouse embryos and reproductive tract

2001 • 44 citations

Isolation, characterization, and chromosomal mapping of mouse P450 17α-hydroxylase/C17–20 lyase

1991 • 42 citations

Increase in transforming growth factor beta1 in ovarian follicular fluid following ovarian stimulation and in-vitro fertilization correlates to pregnancy

1998 • 38 citations

Immunoreactive (ir)-Transforming Growth Factor (TGF)-.BETA. in Rat Corpus Luteum: ir-TGF.BETA. Is Expressed by Luteal Macrophages.

1995 • 23 citations

Fetal and Maternal Transforming Growth Factor-β1 May Combine to Maintain Pregnancy in Mice1

2004 • 20 citations

Deleted Work

1955 • 0 citations