DHEA treatment: myth or reality?

Age Changes and Sex Differences in Serum Dehydroepiandrosterone Sulfate Concentrations throughout Adulthood

1984 • 1,345 citations

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age.

1994 • 852 citations

Intracrinology

1991 • 654 citations

Characterization and measurement of dehydroepiandrosterone sulfate in rat brain.

1981 • 645 citations

Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency

1999 • 642 citations

Dehydroepiandrosterone (DHEA), DHEA sulfate, and aging: Contribution of the DHEAge Study to a sociobiomedical issue

2000 • 578 citations

Effects of replacement dose of dehydroepiandrosterone in men and women of advancing age [published erratum appears in J Clin Endocrinol Metab 1995 Sep;80(9):2799]

1994 • 454 citations

The neurosteroid dehydroepiandrosterone sulfate is an allosteric antagonist of the GABAA receptor

1990 • 433 citations

Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain

1999 • 432 citations

The effect of six months treatment with a 100 mg daily dose of dehydroepiandrosterone (DHEA) on circulating sex steroids, body composition and muscle strength in age‐advanced men and women

1998 • 421 citations

Double-Blind Treatment of Major Depression With Dehydroepiandrosterone

1999 • 411 citations

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men.

1992 • 391 citations

Improvement in Mood and Fatigue after Dehydroepiandrosterone Replacement in Addison’s Disease in a Randomized, Double Blind Trial

2000 • 360 citations

Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Manin Vitro: Possible Link between Endocrinosenescence and Immunosenescence

1998 • 328 citations

Dehydroepiandrosterone: A potential signalling molecule for neocortical organization during development

1998 • 327 citations

Regulation of murine lymphokine production in vivo II. Dehydroepiandrosterone is a natural enhancer of interleukin 2 synthesis by helper T cells

1990 • 324 citations

Decreased psychological well‐being in adult patients with growth hormone deficiency

1994 • 317 citations

Potentiation of neuronal NMDA response induced by dehydroepiandrosterone and its suppression by progesterone: effects mediated via sigma receptors

1996 • 296 citations

Relationships of dehydroepiandrosterone sulfate in the elderly with functional, psychological, and mental status, and short-term mortality: A French community-based study

1996 • 291 citations

Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in Postmenopausal Women

1997 • 285 citations

Dehydroepiandrosterone Activates Endothelial Cell Nitric-oxide Synthase by a Specific Plasma Membrane Receptor Coupled to Gαi2,3

2002 • 285 citations

Evidence for Dissociation between Adrenarche and Gonadarche: Studies in Patients with Idiopathic Precocious Puberty, Gonadal Dysgenesis, Isolated Gonadotropin Deficiency, and Constitutionally Delayed Growth and Adolescence*

1980 • 241 citations

Replacement of DHEA in Aging Men and Women

1995 • 239 citations

Distribution of 17β-hydroxysteroid dehydrogenase gene expression and activity in rat and human tissues

1992 • 228 citations

Receptor binding and electrophysiological effects of Dehydroepiandrosterone sulfate, an antagonist of the GABAA receptor

1991 • 216 citations

Oral dehydroepiandrosterone in physiologic doses modulates immune function in postmenopausal women

1993 • 212 citations

Long-term longitudinal measurements of plasma dehydroepiandrosterone sulfate in normal men

1992 • 207 citations

Dehydroepiandrosterone in systemic lupus erythematosus

1995 • 201 citations

Hormonal Changes in Puberty III: Correlation of Plasma Dehydroepiandrosterone,Testosterone, FSH, and LH with Stages of Puberty and Bone Age in Normal Boys and Girls and in Patients with Addison's Disease or Hypogonadism or with Premature or Late Adrenarche

1975 • 200 citations

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system.

1995 • 191 citations

The presence of a dehydroepiandrosterone-specific receptor binding complex in murine T cells

1992 • 190 citations

A Prospective Study on Cortisol, Dehydroepiandrosterone Sulfate, and Cognitive Function in the Elderly

1998 • 190 citations

Widespread tissue distribution of steroid sulfatase, 3β-hydroxysteroid dehydrogenase/Δ5-Δ4isomerase(3β-HSD), 17β-HSD5α-reductase and aromatase activities in the rhesus monkey

1994 • 189 citations

Dehydroepiandrosterone Replacement in Aging Humans¹

1999 • 189 citations

Improvement in Mood and Fatigue after Dehydroepiandrosterone Replacement in Addison's Disease in a Randomized, Double Blind Trial

2000 • 189 citations

Oral Dehydroepiandrosterone for Adrenal Androgen Replacement: Pharmacokinetics and Peripheral Conversion to Androgens and Estrogens in Young Healthy Females after Dexamethasone Suppression

1998 • 186 citations

Dehydroepiandrosterone treatment of midlife dysthymia∗∗See accompanying Editorial, in this issue.

1999 • 180 citations

Sexual Dimorphism in the Influence of Advanced Aging on Adrenal Hormone Levels: The Rancho Bernardo Study¹

2000 • 180 citations

Dehydroepiandrosterone: Biosynthesis and Metabolism in the Brain

1999 • 177 citations

Postmenopausal dehydroepiandrosterone administration increases free insulin-like growth factor-I and decreases high-density lipoprotein: a six-month trial

1998 • 174 citations

Effects of DHEA replacement on bone mineral density and body composition in elderly women and men

2000 • 173 citations

Prospective measurements of dehydroepiandrosterone sulfate in a cohort of elderly subjects: Relationship to gender, subjective health, smoking habits, and 10-year mortality

2001 • 172 citations

Low Dose Dehydroepiandrosterone Affects Behavior in Hypopituitary Androgen-Deficient Women: A Placebo-Controlled Trial

2002 • 168 citations

Secretion of the adrenal androgen, dehydroepiandrosterone sulfate, during normal infancy, childhood, and adolescence, in sick infants, and in children with endocrinologic abnormalities

1977 • 168 citations

The Effect of Deydroepiandrosterone Supplementation to Symptomatic Perimenopausal Women on Serum Endocrine Profiles, Lipid Parameters, and Health-Related Quality of Life1

1999 • 167 citations

The Actions of Exogenous Dehydroepiandrosterone in Experimental Animals and Humans

1998 • 156 citations

A double-blind, placebo-controlled, clinical trial of dehydroepiandrosterone in severe systemic lupus erythematosus

1999 • 146 citations

The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine-metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds.

1996 • 146 citations

Biotransformation of Oral Dehydroepiandrosterone in Elderly Men: Significant Increase in Circulating Estrogens

1999 • 144 citations

Dehydroepiandrosterone Supplementation in Healthy Men with an Age-Related Decline of Dehydroepiandrosterone Secretion

2001 • 142 citations

Dehydroepiandrosterone Inhibits Human Vascular Smooth Muscle Cell Proliferation Independent of ARs and ERs

2002 • 142 citations

The Longitudinal Study of Adrenal Maturation during Gonadal Suppression: Evidence That Adrenarche Is a Gradual Process

2001 • 141 citations

Neurosteroidogenesis in Astrocytes, Oligodendrocytes, and Neurons of Cerebral Cortex of Rat Brain

1999 • 139 citations

Conversion of dehydroepiandrosterone to downstream steroid hormones in macrophages

2000 • 138 citations

Aging Alters Zonation in the Adrenal Cortex of Men

1997 • 135 citations

Panhypopituitarism as a Model to Study the Metabolism of Dehydroepiandrosterone (DHEA) in Humans¹

1997 • 124 citations

Sexual Dimorphism in the Influence of Advanced Aging on Adrenal Hormone Levels: The Rancho Bernardo Study

2000 • 118 citations

Dehydroepiandrosterone Replacement in Aging Humans

1999 • 117 citations

Dehydroepiandrosterone Sulfate and Mortality in Elderly Men and Women

2001 • 116 citations

Metabolic effects of 12-month percutaneous dehydroepiandrosterone replacement therapy in postmenopausal women.

1996 • 112 citations

Determination of cDNA, gene structure and chromosomal localization of the novel human 17β‐hydroxysteroid dehydrogenase type 7

1999 • 110 citations

Serum Dehydroepiandrosterone (DHEA) and DHEA Sulfate Are Negatively Correlated with Serum Interleukin-6 (IL-6), and DHEA Inhibits IL-6 Secretion from Mononuclear Cells in Man in Vitro: Possible Link between Endocrinosenescence and Immunosenescence

1998 • 105 citations

The influence of age and gender on serum dehydroepiandrosterone sulphate (DHEA-S), IL-6, IL-6 soluble receptor (IL-6 sR) and transforming growth factor beta 1 (TGF-β1) levels in normal healthy blood donors

1999 • 104 citations

Dehydroepiandrosterone in the treatment of erectile dysfunction: a prospective, double-blind, randomized, placebo-controlled study

1999 • 104 citations

Metabolic effects of dehydroepiandrosterone replacement therapy in postmenopausal women

2001 • 103 citations

Origin of Plasma Androstanediol Glucuronide in Men*

1984 • 103 citations

DHEA administration increases rapid eye movement sleep and EEG power in the sigma frequency range

1995 • 103 citations

Effect of 12-Month Dehydroepiandrosterone Replacement Therapy on Bone, Vagina, and Endometrium in Postmenopausal Women

1997 • 96 citations

Steroidogenic enzyme P450c17 is expressed in the embryonic central nervous system

1995 • 96 citations

Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency: Effects on Body Composition, Serum Leptin, Bone Turnover, and Exercise Capacity

2001 • 94 citations

Panhypopituitarism as a Model to Study the Metabolism of Dehydroepiandrosterone (DHEA) in Humans

1997 • 93 citations

Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes.

1995 • 83 citations

Dehydroepiandrosterone modulation of lipopolysaccharide-stimulated monocyte cytotoxicity.

1996 • 81 citations

Androgen Deficiency in Women1

2001 • 74 citations

Dehydroepiandrosterone: Biosynthesis and Metabolism in the Brain

1999 • 73 citations

Quality of Life in Patients with Addison's Disease:

2009 • 71 citations

The relationship of dehydroepiandrosterone sulfate (DHEAS) to endocrine- metabolic parameters and functional status in the oldest-old. Results from an Italian study on healthy free-living over-ninety-year-olds

1996 • 67 citations

Dehydroepiandrosterone Sulfate and Mortality in Elderly Men and Women

2001 • 67 citations

Dehydroepiandrosterone Sulfate Enhances Natural Killer Cell Cytotoxicity in Humans Via Locally Generated Immunoreactive Insulin-Like Growth Factor I¹

1999 • 63 citations

Biotransformation of Oral Dehydroepiandrosterone in Elderly Men: Significant Increase in Circulating Estrogens

1999 • 60 citations

A Prospective Study on Cortisol, Dehydroepiandrosterone Sulfate, and Cognitive Function in the Elderly

1998 • 57 citations

Local estradiol metabolism in osteoblast- and osteoclast-like cells

1997 • 56 citations

Dissociation of Adrenal Androgen and Cortisol Levels in Acute Stress

1985 • 54 citations

Oral Dehydroepiandrosterone for Adrenal Androgen Replacement: Pharmacokinetics and Peripheral Conversion to Androgens and Estrogens in Young Healthy Females after Dexamethasone Suppression

1998 • 51 citations

The Effect of Deydroepiandrosterone Supplementation to Symptomatic Perimenopausal Women on Serum Endocrine Profiles, Lipid Parameters, and Health-Related Quality of Life

1999 • 51 citations

Dehydroepiandrosterone Sulfate Enhances Natural Killer Cell Cytotoxicity in Humans Via Locally Generated Immunoreactive Insulin-Like Growth Factor I

1999 • 48 citations

A pilot study of dehydroepiandrosterone sulfate in myotonic dystrophy

1998 • 48 citations

Low Dose Dehydroepiandrosterone Affects Behavior in Hypopituitary Androgen-Deficient Women: A Placebo-Controlled Trial

2002 • 44 citations

Oestrogen inactivation in the colon: analysis of the expression and regulation of 17 β -hydroxysteroid dehydrogenase isozymes in normal colon and colonic cancer

2000 • 43 citations

Dehydroepiandrosterone Inhibits Human Vascular Smooth Muscle Cell Proliferation Independent of ARs and ERs

2002 • 41 citations

Dehydroepiandrosterone sulfate: kinetics of metabolism in normal young men and women.

1984 • 41 citations

Dehydroepiandrosterone Supplementation in Healthy Men with an Age-Related Decline of Dehydroepiandrosterone Secretion

2001 • 40 citations

Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency: Effects on Body Composition, Serum Leptin, Bone Turnover, and Exercise Capacity

2001 • 37 citations

Up-regulation of high-affinity dehydroepiandrosterone binding activity by dehydroepiandrosterone in activated human T lymphocytes

1995 • 35 citations

Aging Alters Zonation in the Adrenal Cortex of Men

1997 • 35 citations

Precursors of plasma androstanediol- and androgen-glucuronides in women

1989 • 35 citations

Activation of Human Monocytes by LPS and DHEA

1998 • 33 citations

Dehydroepiandrosterone replacement for patients with adrenal insufficiency

2001 • 32 citations

The Longitudinal Study of Adrenal Maturation during Gonadal Suppression: Evidence That Adrenarche Is a Gradual Process

2001 • 32 citations

Dietary supplements of dehydroepiandrosterone in relation to breast cancer risk

1999 • 31 citations

Preliminary studies on the effect of dehydroepiandrosterone (DHEA) on both constitutive and phytohaemagglutinin (PHA)-inducible IL-6 and IL-2 mRNA expression and cytokine production in human spleen mononuclear cell suspensionsin vitro

2001 • 20 citations

Androgen Deficiency in Women

2001 • 20 citations

Dehydroepiandrosterone replacement in addison’s disease

2001 • 12 citations