Metastatic colorectal cancer

Leucovorin and Fluorouracil With or Without Oxaliplatin as First-Line Treatment in Advanced Colorectal Cancer

2000 • 3,785 citations

Cancer Statistics, 2001

2001 • 3,342 citations

Irinotecan combined with fluorouracil compared with fluorouracil alone as first-line treatment for metastatic colorectal cancer: a multicentre randomised trial

2000 • 3,261 citations

Irinotecan plus Fluorouracil and Leucovorin for Metastatic Colorectal Cancer

2000 • 2,981 citations

Liver resection for colorectal metastases.

1997 • 1,298 citations

Randomised trial of irinotecan plus supportive care versus supportive care alone after fluorouracil failure for patients with metastatic colorectal cancer

1998 • 1,273 citations

Modulation of fluorouracil by leucovorin in patients with advanced colorectal cancer: evidence in terms of response rate. Advanced Colorectal Cancer Meta-Analysis Project.

1992 • 1,198 citations

Comparison of Oral Capecitabine Versus Intravenous Fluorouracil Plus Leucovorin as First-Line Treatment in 605 Patients With Metastatic Colorectal Cancer: Results of a Randomized Phase III Study

2001 • 1,132 citations

Randomised trial of irinotecan versus fluorouracil by continuous infusion after fluorouracil failure in patients with metastatic colorectal cancer

1998 • 1,000 citations

Epothilones, a new class of microtubule-stabilizing agents with a taxol-like mechanism of action

1998 • 984 citations

Efficacy of intravenous continuous infusion of fluorouracil compared with bolus administration in advanced colorectal cancer. Meta-analysis Group In Cancer.

1998 • 979 citations

Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis

2000 • 943 citations

Antitumor effect and potentiation of cytotoxic drugs activity in human cancer cells by ZD-1839 (Iressa), an epidermal growth factor receptor-selective tyrosine kinase inhibitor.

2000 • 934 citations

Hepatic Arterial Infusion of Chemotherapy after Resection of Hepatic Metastases from Colorectal Cancer

1999 • 923 citations

Reappraisal of Hepatic Arterial Infusion in the Treatment of Nonresectable Liver Metastases From Colorectal Cancer

1996 • 440 citations

Two consecutive phase II studies of oxaliplatin (L-OHP) for treatment of patients with advanced colorectal carcinoma who were resistant to previous treatment with fluoropyrimidines

1996 • 439 citations

Phase II study of irinotecan in the treatment of advanced colorectal cancer in chemotherapy-naive patients and patients pretreated with fluorouracil-based chemotherapy.

1997 • 434 citations

Phase II study of CPT-11, a new camptothecin derivative, in metastatic colorectal cancer. CPT-11 Gastrointestinal Cancer Study Group.

1993 • 392 citations

Phase II study of fluorouracil and its modulation in advanced colorectal cancer: a Southwest Oncology Group study.

1995 • 365 citations

Irinotecan is an active agent in untreated patients with metastatic colorectal cancer.

1996 • 340 citations

Capecitabine, an Oral Fluoropyrimidine Carbamate With Substantial Activity in Advanced Colorectal Cancer: Results of a Randomized Phase II Study

2000 • 327 citations

Randomized, Multicenter Trial of Fluorouracil Plus Leucovorin Administered Either Via Hepatic Arterial or Intravenous Infusion Versus Fluorodeoxyuridine Administered Via Hepatic Arterial Infusion in Patients With Nonresectable Liver Metastases From Colorectal Carcinoma

2000 • 306 citations

Phase II trial of oxaliplatin as first-line chemotherapy in metastatic colorectal cancer patients. Digestive Group of French Federation of Cancer Centers.

1998 • 302 citations

Palliative chemotherapy for advanced colorectal cancer: systematic review and meta-analysis

2001 • 293 citations

Cryosurgical Ablation and Radiofrequency Ablation for Unresectable Hepatic Malignant Neoplasms

2000 • 277 citations

Phase II trial of irinotecan in patients with metastatic colorectal carcinoma.

1997 • 258 citations

Phase II trial of uracil and tegafur plus oral leucovorin: an effective oral regimen in the treatment of metastatic colorectal carcinoma.

1994 • 208 citations

Phase II study of S-1, a novel oral fluoropyrimidine derivative, in patients with metastatic colorectal carcinoma

2000 • 204 citations

Surgery for lung metastases from colorectal cancer: analysis of prognostic factors.

1996 • 189 citations

Clinical and Immune Responses in Resected Colon Cancer Patients Treated With Anti-Idiotype Monoclonal Antibody Vaccine That Mimics the Carcinoembryonic Antigen

1999 • 163 citations

ZD1694: A novel thymidylate synthase inhibitor with substantial activity in the treatment of patients with advanced colorectal cancer. Tomudex Colorectal Study Group.

1996 • 128 citations

Activity of multitargeted antifolate (pemetrexed disodium, LY231514) in patients with advanced colorectal carcinoma

2000 • 97 citations

Current treatment for colorectal cancer metastatic to the liver

1999 • 66 citations

Phase II study of trimetrexate, fluorouracil, and leucovorin for advanced colorectal cancer.

1997 • 57 citations

Oral Chemotherapeutic Agents for Colorectal Cancer

2000 • 44 citations

Eniluracil: an irreversible inhibitor of dihydropyrimidine dehydrogenase

2000 • 21 citations

RISK FACTORS FOR THE DEVELOPMENT OF COLORECTAL CARCINOMA AND THEIR MODIFICATION

1997 • 5 citations