Interaction of site specific hirudin variants with α-thrombin

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

A gas-liquid solid phase peptide and protein sequenator.

1981 • 2,238 citations

Nucleotide sequence of the rightward operator of phage lambda.

1975 • 2,068 citations

Protides of the Biological Fluids

1969 • 1,623 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

Kinetics of the inhibition of thrombin by hirudin

1986 • 581 citations

The gapped duplex DNA approach to oligonucleotide-directed mutation construction

1984 • 511 citations

The slow-binding and slow, tight-binding inhibition of enzyme-catalysed reactions

1982 • 488 citations

Determination of the operational molarity of solutions of bovine α-chymotrypsin, trypsin, thrombin and factor Xa by spectrofluorimetric titration

1973 • 376 citations

[13] Prothrombin

1976 • 197 citations

Antithrombin properties of C‐terminus of hirudin using synthetic unsulfated N^α‐acetyl‐hirudin_45–65

1987 • 108 citations

Activation of prothrombin with (taipan snake) venom

1973 • 107 citations

The conformations of hirudin in solution: a study using nuclear magnetic resonance, distance geometry and restrained molecular dynamics

1987 • 99 citations

Biosynthesis and periplasmic segregation of human proinsulin in Escherichia coli.

1981 • 81 citations

Expression, secretion and processing of hirudin in E. coli using the alkaline phosphatase signal sequence

1986 • 78 citations

Chemical Synthesis and Expression of a Gene Coding for Hirudin, the Thrombin-Specific Inhibitor from the LeechHirudo medicinalis

1986 • 69 citations

Kinetic Studies on the Interaction of α₁-Proteinase Inhibitor (Pittsburgh) with Trypsin-Like Serine Proteinases

1986 • 39 citations