Biology of Human Umbilical Cord Blood‐Derived Hematopoietic Stem/Progenitor Cells

Telomeres shorten during ageing of human fibroblasts

1990 • 5,530 citations

Structure and function of telomeres

1991 • 3,524 citations

Telomere length predicts replicative capacity of human fibroblasts.

1992 • 2,209 citations

Hematopoietic Reconstitution in a Patient with Fanconi's Anemia by Means of Umbilical-Cord Blood from an HLA-Identical Sibling

1989 • 2,107 citations

Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand.

1987 • 1,627 citations

Localization of mitochondria in living cells with rhodamine 123.

1980 • 1,529 citations

Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor

1990 • 1,448 citations

The SCID-hu Mouse: Murine Model for the Analysis of Human Hematolymphoid Differentiation and Function

1988 • 1,394 citations

The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene

1988 • 1,336 citations

Human umbilical cord blood as a potential source of transplantable hematopoietic stem/progenitor cells.

1989 • 1,220 citations

Antigenic analysis of hematopoiesis. III. A hematopoietic progenitor cell surface antigen defined by a monoclonal antibody raised against KG-1a cells.

1984 • 1,193 citations

Evidence for a mitotic clock in human hematopoietic stem cells: loss of telomeric DNA with age.

1994 • 1,133 citations

Isolation of a candidate human hematopoietic stem-cell population.

1992 • 1,098 citations

Regulatory Mechanisms in Stem Cell Biology

1997 • 1,060 citations

Human gene therapy comes of age

1992 • 927 citations

Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms

1990 • 870 citations

Processing and cryopreservation of placental/umbilical cord blood for unrelated bone marrow reconstitution.

1995 • 823 citations

Characterization and partial purification of human marrow cells capable of initiating long-term hematopoiesis in vitro

1989 • 699 citations

Engraftment of gene–modified umbilical cord blood cells in neonates with adenosine deaminase deficiency

1995 • 622 citations

Cytokine Stimulation of Multilineage Hematopoiesis from Immature Human Cells Engrafted in SCID Mice

1992 • 555 citations

Growth characteristics and expansion of human umbilical cord blood and estimation of its potential for transplantation in adults.

1992 • 506 citations

Selection of Drug-Resistant Bone Marrow Cells in Vivo After Retroviral Transfer of Human MDR 1

1992 • 500 citations

Primitive Human Hematopoietic Cells Are Enriched in Cord Blood Compared With Adult Bone Marrow or Mobilized Peripheral Blood as Measured by the Quantitative In Vivo SCID-Repopulating Cell Assay

1997 • 488 citations

Expression of Thy-1 on human hematopoietic progenitor cells.

1993 • 477 citations

Engraftment of Immune-Deficient Mice with Human Hematopoietic Stem Cells

1988 • 471 citations

In vivo loss of telomeric repeats with age in humans

1991 • 469 citations

Extensive Amplification and Self-Renewal of Human Primitive Hematopoietic Stem Cells From Cord Blood

1997 • 464 citations

A functional comparison of CD34 + CD38- cells in cord blood and bone marrow

1995 • 456 citations

Functional Isolation and Characterization of Human Hematopoietic Stem Cells

1995 • 414 citations

Ontogeny-related changes in proliferative potential of human hematopoietic cells.

1993 • 413 citations

Placental and/or Umbilical Cord Blood: An Alternative Source of Hematopoietic Stem Cells for Transplantation

1997 • 402 citations

Combination of interleukins 3 and 6 preserves stem cell function in culture and enhances retrovirus-mediated gene transfer into hematopoietic stem cells.

1989 • 316 citations

Hemopoietic colony-forming cells in umbilical cord blood with extensive capability to generate mono- and multipotential hemopoietic progenitors.

1982 • 312 citations

Immature human cord blood progenitors engraft and proliferate to high levels in severe combined immunodeficient mice

1994 • 283 citations

Purified primitive human hematopoietic progenitor cells with long-term in vitro repopulating capacity adhere selectively to irradiated bone marrow stroma.

1990 • 275 citations

Engraftment and long-term expression of human fetal hemopoietic stem cells in sheep following transplantation in utero.

1992 • 243 citations

Renewal and commitment to differentiation of hemopoietic stem cells (an interpretive review)

1983 • 243 citations

Enrichment, characterization, and responsiveness of single primitive CD34 human umbilical cord blood hematopoietic progenitors with high proliferative and replating potential

1993 • 235 citations

Disparate differentiation in mouse hemopoietic colonies derived from paired progenitors.

1984 • 233 citations

In Vitro Growth of Granulocytic Colonies From Circulating Cells in Human Cord Blood

1974 • 221 citations

Growth of human umbilical-cord blood in longterm haemopoietic cultures

1992 • 217 citations

Engraftment and Development of Human CD34+-Enriched Cells From Umbilical Cord Blood in NOD/LtSz-scid/scid Mice

1997 • 215 citations

Biology of the hemopoietic microenvironment

1992 • 204 citations

Hemopoietic colonies: in vitro cloning of normal and leukemic cells.

1977 • 202 citations

Sensitive detection and enumeration of CD34+ cells in peripheral and cord blood by flow cytometry.

1994 • 201 citations

The CD34 Antigen: Structure, Biology, and Potential Clinical Applications

1992 • 198 citations

Renewal and commitment to differentiation of hemopoietic stem cells (an interpretive review)

1983 • 190 citations

Release from quiescence of CD34+ CD38- human umbilical cord blood cells reveals their potentiality to engraft adults.

1993 • 189 citations

RETRACTED ARTICLE: Formation of haematopoietic microenvironment and haematopoietic stem cells from single human bone marrow stem cells

1992 • 183 citations

The stem cell antigen CD34 functions as a regulator of hemopoietic cell adhesion.

1995 • 183 citations

Thy-1 expression is linked to functional properties of primitive hematopoietic progenitor cells from human umbilical cord blood

1994 • 178 citations

Distribution of surface-membrane molecules on bone marrow and cord blood CD34+ hematopoietic cells.

1992 • 177 citations

Direct comparison by limiting dilution analysis of long-term culture- initiating cells in human bone marrow, umbilical cord blood, and blood stem cells

1994 • 170 citations

Long-term repopulating ability of xenogeneic transplanted human fetal liver hematopoietic stem cells in sheep.

1994 • 155 citations

Blast cell colony assay for umbilical cord blood and adult bone marrow progenitors

1987 • 152 citations

Clonal analysis of proliferation and differentiation of paired daughter cells: action of granulocyte-macrophage colony-stimulating factor on granulocyte-macrophage precursors.

1980 • 147 citations

Mast cell growth factor (c-kit ligand) supports the growth of human multipotential progenitor cells with a high replating potential

1991 • 144 citations

Endothelial cell precursors are normal components of human umbilical cord blood

1997 • 141 citations

Detection of a human CFC with a high proliferative potential

1989 • 135 citations

Functional and phenotypic characterization of cord blood and bone marrow subsets expressing FLT3 (CD135) receptor tyrosine kinase

1997 • 134 citations

Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of recombinant human stem cell factor

1992 • 133 citations

Evaluation of the in vitro behavior of phenotypically defined populations of umbilical cord blood hematopoietic progenitor cells.

1994 • 129 citations

Analysis of differentiation of mouse hemopoietic stem cells in culture by sequential replating of paired progenitors

1984 • 125 citations

Human cord blood cells as targets for gene transfer: potential use in genetic therapies of severe combined immunodeficiency disease.

1993 • 122 citations

Human fetal bone marrow early progenitors for T, B, and myeloid cells are found exclusively in the population expressing high levels of CD34

1994 • 122 citations

Single cell origin of multilineage colonies in culture. Evidence that differentiation of multipotent progenitors and restriction of proliferative potential of monopotent progenitors are stochastic processes.

1984 • 119 citations

Lineage commitment of hemopoietic progenitor cells in developing blast cell colonies: influence of colony-stimulating factors.

1991 • 117 citations

Telomere length and proliferation potential of hematopoietic stem cells

1995 • 117 citations

Cell surface antigens on human marrow cells: Dissection of hematopoietic development using monoclonal antibodies and multiparameter flow cytometry

1987 • 115 citations

Adeno-associated virus 2-mediated high efficiency gene transfer into immature and mature subsets of hematopoietic progenitor cells in human umbilical cord blood.

1994 • 114 citations

Individual CD34+CD38lowCD19−CD10− Progenitor Cells From Human Cord Blood Generate B Lymphocytes and Granulocytes

1997 • 112 citations

Human multipotential progenitor cells (CFU-GEMM) have extensive replating capacity for secondary CFU-GEMM: an effect enhanced by cord blood plasma

1993 • 112 citations

Cytokine-induced selective expansion and maturation of erythroid versus myeloid progenitors from purified cord blood precursor cells

1993 • 110 citations

Antigenic Analysis of Hematopoiesis: A Review

1993 • 109 citations

Long-term generation of colony-forming cells in liquid culture of CD34+ cord blood cells in the presence of recombinant human stem cell factor

1992 • 108 citations

High efficiency retroviral mediated gene transduction into single isolated immature and replatable CD34(3+) hematopoietic stem/progenitor cells from human umbilical cord blood.

1993 • 106 citations

Hematopoietic potential of cryopreserved and ex vivo manipulated umbilical cord blood progenitor cells evaluated in vitro and in vivo

1996 • 104 citations

Phenotype analysis of hematopoietic CD34+ cell populations derived from human umbilical cord blood using flow cytometry and cDNA-polymerase chain reaction

1994 • 102 citations

Lineage commitment in human hemopoiesis involves asymmetric cell division of multipotent progenitors and does not appear to be influenced by cytokines

1993 • 100 citations

Improved engraftment of human cord blood stem cells in NOD/LtSz-scid/scid mice after irradiation or multiple-day injections into unirradiated recipients.

1996 • 99 citations

Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines

1993 • 96 citations

Rapid exit from G0/G1 phases of cell cycle in response to stem cell factor confers on umbilical cord blood CD34+ cells an enhanced ex vivo expansion potential.

1994 • 87 citations

Differential effects of the hematopoietic inhibitors MIP-1 alpha, TGF-beta, and TNF-alpha on cytokine-induced proliferation of subpopulations of CD34+ cells purified from cord blood and fetal liver.

1995 • 83 citations

Long-term culture system for selective growth of human B-cell progenitors.

1995 • 82 citations

Ex vivo expansion of cord blood-derived stem cells and progenitors.

1994 • 79 citations

High levels of granulocyte and granulocyte-macrophage colony-stimulating factors in cord blood of normal full-term neonates

1990 • 77 citations

Characterization of functionally distinct subpopulations of CD34+ cord blood cells in serum-free long-term cultures supplemented with hematopoietic cytokines

1993 • 77 citations

Sequential loss of CD34 and class II MHC antigens on purified cord blood hematopoietic progenitors cultured with IL-3: characterization of CD34-, HLA-DR+ cells

1989 • 73 citations

Developmental changes in the function of hematopoietic stem cells.

1995 • 72 citations

Cord blood banking for hematopoietic stem cell transplantation: an international cord blood transplant registry.

1993 • 72 citations

Gene transfer to primary normal and malignant human hemopoietic progenitors using recombinant retroviruses

1987 • 69 citations

Reconstitution of SCID mice with human lymphoid and myeloid cells after transplantation with human fetal bone marrow without the requirement for exogenous human cytokines.

1994 • 68 citations

Combined and sequential effects of human IL-3 and GM-CSF on the proliferation of CD34+ hematopoietic cells from cord blood

1989 • 67 citations

Long-term generation of human mast cells in serum-free cultures of CD34+ cord blood cells stimulated with stem cell factor and interleukin- 3

1994 • 60 citations

Harvesting, characterization, and culture of CD34+ cells from human bone marrow, peripheral blood, and cord blood.

1994 • 57 citations

Subpopulations of CD34‐positive haemopoietic progenitors in fetal blood

1994 • 55 citations

Possible mechanisms accounting for the growth factor independence of hematopoietic progenitors from umbilical cord blood

1994 • 53 citations

Kinetics of Hematopoiesis in Dexter‐Type Long‐Term Cultures Established from Human Umbilical Cord Blood Cells

1998 • 51 citations

Comparison of the Phenotype and Clonogenicity of Normal CD34⁺Cells from Umbilical Cord Blood, Granulocyte Colony-Stimulating Factor-Mobilized Peripheral Blood, and Adult Human Bone Marrow

1994 • 49 citations

Age-related decline in proliferative potential of purified stem cell candidates.

1994 • 48 citations

Characterization of hemopoietic cell populations from human cord blood expressing c-kit.

1993 • 47 citations

The response of cord blood megakaryocyte progenitors to IL‐3, IL‐6 and aplastic canine serum varies with gestational age

1995 • 47 citations

Comparative study of CD34-positive cells and subpopulations in human umbilical cord blood and bone marrow.

1993 • 45 citations

Umbilical cord blood transplantation: overview of the clinical experience.

1994 • 43 citations

IL-11 in combination with SLF and G-CSF or GM-CSF significantly increases expansion of isolated CD34+ cell population from cord blood vs. adult bone marrow.

1995 • 42 citations

Study of early hematopoietic precursors in human cord blood.

1992 • 41 citations

Retention and multilineage expression of human hematopoietic stem cells in human‐sheep chimeras

1995 • 40 citations

Cytokine-dependent ex vivo expansion of early subsets of CD34+ cord blood myeloid progenitors is enhanced by cord blood plasma, but expansion of the more mature subsets of progenitors is favored.

1994 • 36 citations

Interleukin-6 is a component of human umbilical cord serum and stimulates hematopoiesis in embryonic stem cells in vitro.

1993 • 29 citations

Extensive Amplification of Single Cells from CD34 ⁺ Subpopulations in Umbilical Cord Blood and Identification of Long‐Term Culture‐Initiating Cells Present in Two Subsets

1996 • 27 citations

Hemopoietic stem cells: stochastic differentiation and humoral control of proliferation.

1989 • 27 citations

Expression of interleukin-1 beta gene in candidate human hematopoietic stem cells

1994 • 26 citations

Stochastic versus deterministic in haemopoiesis: what is what?

1991 • 25 citations

Proliferation of individual hematopoietic progenitors purified from umbilical cord blood.

1995 • 23 citations

Extensive proliferative capacity of single isolated CD34 human cord blood cells in suspension culture.

1994 • 22 citations

Ex VivoExpansion and Gene Therapy Using Cord Blood CD34⁺Cells

1993 • 22 citations

Production of interleukin 1beta by human hematopoietic progenitor cells.

1996 • 22 citations

Effects of recombinant human Steel factor (c-kit ligand) on early cord blood hematopoietic precursors.

1994 • 20 citations

The effect of cytokines on CD34+ Rh-123high and low progenitor cells from human umbilical cord blood.

1994 • 19 citations

Long-Term Generation of Colony-Forming Cells (CFC) from CD34+Human Umbilical Cord Blood Cells

1993 • 19 citations

Does Cord Blood Contain Enough Progenitor Cells for Transplantation?

1994 • 16 citations

Isolation and ex vivo expansion of CD34+ cells from cord blood using dextran sedimentation and avidin column selection.

1994 • 15 citations

Retention and multilineage expression of human hematopoietic stem cells in human-sheep chimeras.

1994 • 14 citations

Effects of mast cell growth factor, interleukin-3, and interleukin-6 on human primitive hematopoietic progenitors from bone marrow and cord blood.

1993 • 14 citations

Expansion of human neonatal progenitor cells in vitro under serum-deprived conditions.

1994 • 12 citations

Differential responses of fetal, neonatal, and adult myelopoietic progenitors to interferon and tumor necrosis factor.

1994 • 9 citations

Purification and release from quiescence of umbilical cord blood early progenitors reveal their potential to engraft adults.

1994 • 9 citations

Models of haemopoiesis

1990 • 7 citations

Hemopoietic Stem Cells: Stochastic Differentiation and Humoral Control of Proliferation

1989 • 4 citations

Long-Term Multilineage Development from Human Umbilical Cord Blood Stem Cells in a Novel SCID-HU Graft

1996 • 3 citations