Dendritic spine plasticity in hippocampus

Long-Term Potentiation--A Decade of Progress?

1999 • 2,701 citations

The new stereological tools: Disector, fractionator, nucleator and point sampled intercepts and their use in pathological research and diagnosis

1988 • 2,498 citations

Dendritic spine changes associated with hippocampal long-term synaptic plasticity

1999 • 1,694 citations

Synaptic tagging and long-term potentiation

1997 • 1,689 citations

Stereology of arbitrary particles. A review of unbiased number and size estimators and the presentation of some new ones, in memory of William R. Thompson.

1986 • 1,669 citations

Stereology of arbitrary particles*

1986 • 1,404 citations

Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood

1990 • 1,352 citations

Activation of postsynaptically silent synapses during pairing-induced LTP in CA1 region of hippocampal slice

1995 • 1,342 citations

A Synaptically Controlled, Associative Signal for Hebbian Plasticity in Hippocampal Neurons

1997 • 1,338 citations

Inhibition of Postsynaptic PKC or CaMKII Blocks Induction But Not Expression of LTP

1989 • 1,335 citations

Rapid Spine Delivery and Redistribution of AMPA Receptors After Synaptic NMDA Receptor Activation

1999 • 1,272 citations

Evidence for silent synapses: Implications for the expression of LTP

1995 • 1,212 citations

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat.

1992 • 1,178 citations

Naturally occurring fluctuation in dendritic spine density on adult hippocampal pyramidal neurons

1990 • 1,080 citations

Roles of estradiol and progesterone in regulation of hippocampal dendritic spine density during the estrous cycle in the rat

1993 • 1,066 citations

An essential role for postsynaptic calmodulin and protein kinase activity in long-term potentiation

1989 • 1,015 citations

LTP promotes formation of multiple spine synapses between a single axon terminal and a dendrite

1999 • 964 citations

Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat [published erratum appears in J Neurosci 1992 Oct;12(10):following table of contents]

1992 • 959 citations

New stereological methods for counting neurons

1993 • 951 citations

Dendritic spines as basic functional units of neuronal integration

1995 • 933 citations

Rapid Actin-Based Plasticity in Dendritic Spines

1998 • 920 citations

Actin-Based Plasticity in Dendritic Spines

2000 • 813 citations

Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

1997 • 738 citations

Effects of estrogen on memory function in surgically menopausal women

1992 • 728 citations

Protein Synthesis at Synaptic Sites on Dendrites

2001 • 682 citations

Estradiol regulates hippocampal dendritic spine density via an N-methyl- D-aspartate receptor-dependent mechanism

1994 • 679 citations

Estradiol Increases the Sensitivity of Hippocampal CA1 Pyramidal Cells to NMDA Receptor-Mediated Synaptic Input: Correlation with Dendritic Spine Density

1997 • 679 citations

Different modes of expression of AMPA and NMDA receptors in hippocampal synapses

1999 • 673 citations

KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.

1990 • 630 citations

Biochemical and immunochemical evidence that the "major postsynaptic density protein" is a subunit of a calmodulin-dependent protein kinase.

1983 • 617 citations

Dendritic Spine Structural Anomalies in Fragile-X Mental Retardation Syndrome

2000 • 607 citations

An increase in dendritic spine density on hippocampal CA1 pyramidal cells following spatial learning in adult rats suggests the formation of new synapses.

1994 • 603 citations

Maturation of a Central Glutamatergic Synapse

1996 • 551 citations

Synaptogenesis and FOS Expression in the Motor Cortex of the Adult Rat after Motor Skill Learning

1996 • 541 citations

Transient and enduring morphological correlates of synaptic activity and efficacy change in the rat hippocampal slice

1984 • 531 citations

Local calcium signalling by inositol-1,4,5-trisphosphate in Purkinje cell dendrites

1998 • 521 citations

Dendritic Spine "Dysgenesis" and Mental Retardation

1974 • 520 citations

Structure, development, and plasticity of dendritic spines

1999 • 511 citations

Selective acquisition of AMPA receptors over postnatal development suggests a molecular basis for silent synapses

1999 • 496 citations

Dendritic spines as individual neuronal compartments for synaptic Ca2+ responses

1991 • 487 citations

Advances in second messenger and phosphoprotein research

1992 • 481 citations

Neurotoxicity of excitatory amino acids

1990 • 466 citations

Estradiol Increases Dendritic Spine Density by Reducing GABA Neurotransmission in Hippocampal Neurons

1998 • 460 citations

LTP varies across the estrous cycle: enhanced synaptic plasticity in proestrus rats

1995 • 430 citations

A new class of synaptic response involving calcium release in dendritic spines

1998 • 415 citations

Regulation of Dendritic Spine Density in Cultured Rat Hippocampal Neurons by Steroid Hormones

1996 • 402 citations

Reduction in number of immunostained GABAergic neurones in deprived-eye dominance columns of monkey area 17

1986 • 393 citations

Evidence that the major postsynaptic density protein is a component of a Ca2+/calmodulin-dependent protein kinase.

1984 • 389 citations

Stabilization of Dendritic Arbor Structure in Vivo by CaMKII

1998 • 381 citations

The function of dendritic spines: devices subserving biochemical rather than electrical compartmentalization

1993 • 378 citations

Modulation of an NCAM-Related Adhesion Molecule with Long-Term Synaptic Plasticity in Aplysia

1992 • 377 citations

Differential Regulation of NMDAR1 mRNA and Protein by Estradiol in the Rat Hippocampus

1996 • 376 citations

Increasing Numbers of Synaptic Puncta during Late-Phase LTP

2000 • 373 citations

Variability of Neurotransmitter Concentration and Nonsaturation of Postsynaptic AMPA Receptors at Synapses in Hippocampal Cultures and Slices

1999 • 357 citations

Cognitive function in nondemented older women who took estrogen after menopause

1998 • 336 citations

CaMKIIβ Functions As an F-Actin Targeting Module that Localizes CaMKIIα/β Heterooligomers to Dendritic Spines

1998 • 336 citations

Synaptic calcium transients in single spines indicate that NMDA receptors are not saturated

1999 • 321 citations

FUNCTION-RELATED PLASTICITY IN HYPOTHALAMUS

1997 • 320 citations

Molecular Modification of N-Cadherin in Response to Synaptic Activity

2000 • 306 citations

NMDA Receptor Content of Synapses in Stratum Radiatum of the Hippocampal CA1 Area

2000 • 294 citations

Estradiol selectively regulates agonist binding sites on the N-methyl-D-aspartate receptor complex in the CA1 region of the hippocampus.

1992 • 284 citations

Independent regulation of calcium revealed by imaging dendritic spines

1991 • 272 citations

Induction of long-term potentiation is associated with an increase in the number of axospinous synapses with segmented postsynaptic densities

1991 • 272 citations

cAMP Evokes Long-Term Facilitation in Aplysia Sensory Neurons That Requires New Protein Synthesis

1988 • 265 citations

Induction of long-term potentiation is associated with major ultrastructural changes of activated synapses.

1996 • 265 citations

Structural Synaptic Modifications Associated with Hippocampal LTP and Behavioral Learning

2000 • 261 citations

Synapse specificity of long-term potentiation breaks down at short distances

1997 • 258 citations

Do dendritic spines twitch?

1982 • 254 citations

Stages of Synapse Development Defined by Dependence on F-Actin

2001 • 253 citations

Mechanisms of Calcium Decay Kinetics in Hippocampal Spines: Role of Spine Calcium Pumps and Calcium Diffusion through the Spine Neck in Biochemical Compartmentalization

2000 • 246 citations

Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons

1998 • 242 citations

Estrogen facilitates induction of long term potentiation in the hippocampus of awake rats1First published on the World Wide Web on 4 November 1997.1

1997 • 234 citations

Different modes of hippocampal plasticity in response to estrogen in young and aged female rats

2001 • 223 citations

Estradiol increases the frequency of multiple synapse boutons in the hippocampal CA1 region of the adult female rat

1996 • 219 citations

Nonsaturation of AMPA and NMDA receptors at hippocampal synapses

2000 • 219 citations

Age-related alterations in potentiation in the CA1 region in F344 rats

1993 • 216 citations

Changes in the numerical density of synaptic contacts with long‐term potentiation in the hippocampal dentate gyrus

1986 • 210 citations

Changes in the postsynaptic density with long‐term potentiation in the dentate gyrus

1986 • 206 citations

Making memories stick: cell-adhesion molecules in synaptic plasticity

2000 • 198 citations

Down's dyndrome and Alzheimer's disease: dendritic spine counts in the hippocampus

1990 • 194 citations

Repeated confocal imaging of individual dendritic spines in the living hippocampal slice: evidence for changes in length and orientation associated with chemically induced LTP

1995 • 190 citations

Release of calcium from stores alters the morphology of dendritic spines in cultured hippocampal neurons

1999 • 189 citations

Stability in Synapse Number and Size at 2 Hr after Long-Term Potentiation in Hippocampal Area CA1

1998 • 186 citations

Mutation in the Phosphorylation Sites of MAP Kinase Blocks Learning-Related Internalization of apCAM in Aplysia Sensory Neurons

1997 • 185 citations

Circuit-specific alterations of N-methyl-D-aspartate receptor subunit 1 in the dentate gyrus of aged monkeys.

1996 • 177 citations

Calcium · calmodulin-dependent protein kinase II and calcium · phospholipid-dependent protein kinase activities in rat tissues assayed with a synthetic peptide

1987 • 173 citations

Estradiol selectively regulates agonist binding sites on the N-methyl-D- aspartate receptor complex in the CA1 region of the hippocampus

1992 • 169 citations

Immunoreactivity for a calmodulin-dependent protein kinase is selectively increased in macaque striate cortex after monocular deprivation.

1986 • 168 citations

Transient spine density increases in the mid-molecular layer of hippocampal dentate gyrus accompany consolidation of a spatial learning task in the rodent

2000 • 158 citations

Differential effects of monocular deprivation on glutamic acid decarboxylase and type II calcium-calmodulin-dependent protein kinase gene expression in the adult monkey visual cortex [published erratum appears in J Neurosci 1991 May;11(5):following Table of Contents]

1991 • 154 citations

Morphometric and dendritic analysis of fascia dentata granule cells in human aging and senile dementia

1987 • 145 citations

Synapse restructuring associated with the maintenance phase of hippocampal long-term potentiation

1996 • 142 citations

Quantitative study on dendrites and dendritic spines in Alzheimer's disease and senile dementia.

1975 • 129 citations

LTP induction threshold change in old rats at the perforant path–granule cell synapse

2000 • 128 citations

Postsynaptic Calcium/Calmodulin-Dependent Protein Kinase II Is Required to Limit Elaboration of Presynaptic and Postsynaptic Neuronal Arbors

1999 • 127 citations

The synaptic glycoprotein neuroplastin is involved in long-term potentiation at hippocampal CA1 synapses

2000 • 121 citations

Synaptic interface surface area increases with long-term potentiation in the hippocampal dentate gyrus

1988 • 117 citations

Long-term potentiation is associated with new excitatory spine synapses on rat dentate granule cells.

1996 • 116 citations

Hippocampal dependent learning ability correlates with N‐methyl‐D‐aspartate (NMDA) receptor levels in CA3 neurons of young and aged rats

2001 • 109 citations

Functional integrity of NMDA-dependent LTP induction mechanisms across the lifespan of F-344 rats.

1996 • 99 citations

Dendritic pathology of granule cells in Alzheimer's disease is unrelated to neuritic plaques

1994 • 98 citations

Olfactory learning is associated with increased spine density along apical dendrites of pyramidal neurons in the rat piriform cortex

2001 • 98 citations

Synaptic vesicle redistribution during hippocampal frequency potentiation and depression in young and aged rats

1988 • 92 citations

Intracellular signaling pathways that regulate dendritic spine morphogenesis

2000 • 89 citations

Axospinous synapses with segmented postsynaptic densities: a morphologically distinct synaptic subtype contributing to the number of profiles of ‘perforated’ synapses visualized in random sections

1987 • 81 citations

Perforated synapses on double-headed dendritic spines: a possible structural substrate of synaptic plasticity

1989 • 81 citations

Excitotoxic activation of the NMDA receptor results in inhibition of calcium/calmodulin kinase II activity in cultured hippocampal neurons

1995 • 77 citations

Genetic analysis of learning behavior-induced structural plasticity

2000 • 77 citations

Changes in expression and distribution of Aplysia cell adhesion molecules can influence synapse formation and elimination in vitro

1995 • 76 citations

Decreased numbers of dendritic spines on cortical pyramidal neurons in dementia. A quantitative Golgi study on biopsy samples.

1988 • 71 citations

Development and molecular organization of dendritic spines and their synapses

2000 • 67 citations

Synaptic coexistence of AMPA and NMDA receptors in the rat hippocampus: A postembedding immunogold study

1998 • 65 citations

CREB Activation Mediates Plasticity in Cultured Hippocampal Neurons

1998 • 63 citations

The septo-hippocampal pathway in patients suffering from senile dementia of Alzheimer's type. Evidence for neuronal plasticity?

1987 • 53 citations

Long-Term Plasticity at Excitatory Synapses on Aspinous Interneurons in Area CA1 Lacks Synaptic Specificity

1998 • 53 citations

Gonadal steroids and astroglial plasticity

1996 • 44 citations

Alpha isoform of calciumcalmodulin dependent protein kinase II (CAM II kinase-α) restricted to excitatory synapses in the CA1 region of rat hippocampus

1997 • 33 citations

Differences in the Complexity of Song Tutoring Cause Differences in the Amount Learned and in Dendritic Spine Density in a Songbird Telencephalic Song Control Nucleus

2000 • 27 citations

Dendritic spines and immunoreactivity of synaptophysin in the frontal cortex of humans with infantile brain damage. A correlative study.

1994 • 8 citations