Beta-cell hypersensitivity to glucose following 24-h exposure of rat islets to fatty acids

Long-term exposure of rat pancreatic islets to fatty acids inhibits glucose-induced insulin secretion and biosynthesis through a glucose fatty acid cycle.

1994 • 683 citations

A SENSITIVE, PRECISE RADIOIMMUNOASSAY OF SERUM INSULIN RELYING ON CHARCOAL SEPARATION OF BOUND AND FREE HORMONE MOIETIES

1972 • 634 citations

Glucokinase as Glucose Sensor and Metabolic Signal Generator in Pancreatic β-Cells and Hepatocytes

1990 • 603 citations

METABOLIC COUPLING FACTORS IN PANCREATIC β-CELL SIGNAL TRANSDUCTION

1995 • 529 citations

Pancreatic islet glucose metabolism and regulation of insulin secretion

1986 • 506 citations

Are the β-Cell Signaling Molecules Malonyl-CoA and Cystolic Long-Chain Acyl-CoA Implicated in Multiple Tissue Defects of Obesity and NIDDM?

1996 • 466 citations

Malonyl-CoA and long chain acyl-CoA esters as metabolic coupling factors in nutrient-induced insulin secretion.

1992 • 440 citations

Dietary Polyunsaturated Fatty Acid Regulation of Gene Transcription

1994 • 305 citations

The pentose cycle and insulin release in mouse pancreatic islets

1972 • 304 citations

Pancreatic β-Cells in Obesity

1995 • 276 citations

Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications

1995 • 269 citations

A Role for Malonyl-CoA in Glucose-Stimulated Insulin Secretion from Clonal Pancreatic β-Cells

1989 • 259 citations

Fatty acylation of proteins

1989 • 230 citations

REPRODUCIBLE HIGH YIELD OF RAT ISLETS BY STATIONARY IN VITRO DIGESTION FOLLOWING PANCREATIC DUCTAL OR PORTAL VENOUS COLLAGENASE INJECTION1

1987 • 220 citations

Feedback Inhibition of Key Glycolytic Enzymes in Liver: Action of Free Fatty Acids

1966 • 171 citations

Heterogeneity in glucose sensitivity among pancreatic beta-cells is correlated to differences in glucose phosphorylation rather than glucose transport.

1993 • 168 citations

A method for deriving kinetic constants for two enzymes acting on the same substrate

1971 • 165 citations

Stimulation of insulin secretion by noncarbohydrate metabolites.

1968 • 160 citations

Specific inhibition of glucokinase by long chain acyl coenzymes A below the critical micelle concentration.

1982 • 140 citations

Glucokinase of rabbit liver: purification and properties

1965 • 134 citations

Inhibition of acyl-CoA synthetase by triacsins.

1987 • 132 citations

Evidence for an essential role of long chain acyl-CoA synthetase in animal cell proliferation

1991 • 124 citations

Inhibition of acyl-CoA synthetase by triacsins

1987 • 122 citations

Hexose metabolism in pancreatic islets. Inhibition of hexokinase

1984 • 102 citations

Glucose regulates glucokinase activity in cultured islets from rat pancreas.

1990 • 101 citations

Hexose metabolism in pancreatic islets

1990 • 96 citations

Effect of fatty acids on insulin release: role of chain length and degree of unsaturation

1994 • 92 citations

Palmitate-Induced β-Cell Insensitivity to Glucose is Coupled to Decreased Pyruvate Dehydrogenase Activity and Enhanced Kinase Activity in Rat Pancreatic Islets

1995 • 89 citations

Fat-induced changes in mouse pancreatic islet insulin secretion, insulin biosynthesis and glucose metabolism

1992 • 57 citations

Beta-cell hypersensitivity for glucose precedes loss of glucose-induced insulin secretion in 90% pancreatectomized rats

1993 • 54 citations

Long chain acyl coenzyme A and signaling in neutrophils. An inhibitor of acyl coenzyme A synthetase, triacsin C, inhibits superoxide anion generation and degranulation by human neutrophils.

1994 • 54 citations

Glucose-6-phosphatase activity in islets from ob/ob and lean mice and the effect of dexamethasone.

1995 • 49 citations

Glucose Cycling Is Markedly Enhanced in Pancreatic Islets of Obese Hyperglycemic Mice*

1990 • 43 citations

Characterization of the insulinotropic potency of polyunsaturated fatty acids.

1992 • 41 citations

Threshold for Glucose-Stimulated Insulin Secretion in Pancreatic Islets of Genetically Obese (ob/ob) Mice is Abnormally Low

1993 • 38 citations

Fatty acyl-CoA esters inhibit glucose-6-phosphatase in rat liver microsomes

1995 • 38 citations

Upregulated Hexokinase Activity in Isolated Islets from Diabetic 90% Pancreatectomized Rats

1995 • 37 citations

Effect of oleic acid on insulin secretion by the isolated perfused rat pancreas

1979 • 36 citations

In vivo and in vitro increased pancreatic beta-cell sensitivity to glucose in normal rats submitted to a 48-h hyperglycaemic period

1993 • 24 citations

Dietary Polyunsaturated Fatty Acid Regulation of Gene Transcription

1994 • 19 citations

Altered Glucose Dependence of Glucagon-Like Peptide I(7–36)–Induced Insulin Secretion from the Zucker (fa/fa) Rat Pancreas

1995 • 17 citations

Glucose-6-phosphatase activity in islets from ob/ob and lean mice and the effect of dexamethasone

1995 • 15 citations

Characterization of the insulinotropic potency of polyunsaturated fatty acids

1992 • 14 citations

Altered glucose dependence of glucagon-like peptide I(7-36)-induced insulin secretion from the Zucker (fa/fa) rat pancreas

1995 • 10 citations

Increased glucose phosphorylating activity correlates with insulin secretory capacity of male JCR:LA-corpulent rat islets

1995 • 10 citations

The pentose cycle and insulin release in mouse pancreatic islets

1972 • 6 citations

Fatty Acylation of Proteins

1988 • 2 citations

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