Chronic administration of morphine and naltrexone up-regulate μ-opioid binding sites labeled by [3H][D-Ala2, MePhe4, Gly-ol5]enkephalin: further evidence for two μ-binding sites

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Multiple opiate receptors. Enkephalins and morphine bind to receptors of different specificity.

1979 • 684 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

Isolation, sequencing, synthesis, and pharmacological characterization of two brain neuropeptides that modulate the action of morphine.

1985 • 594 citations

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

1983 • 582 citations

Mismatches between neurotransmitter and receptor localizations in brain: observations and implications

1987 • 524 citations

Statistics: A Biomedical Introduction

1980 • 466 citations

CHARACTERIZATION OF THE k‐SUBTYPE OF THE OPIATE RECEPTOR IN THE GUINEA‐PIG BRAIN

1981 • 423 citations

Characterization and visualization of rat and guinea pig brain kappa opioid receptors: evidence for kappa 1 and kappa 2 opioid receptors.

1988 • 315 citations

Quantitative aspects of precipitated abstinence in morphine-dependent rats.

1973 • 252 citations

Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides on analgesia

1982 • 233 citations

Statistics: A Biomedical Introduction.

1978 • 224 citations

Differential ontogeny of multiple opioid receptors (mu, delta, and kappa)

1985 • 223 citations

Neurochemical and functional correlates of naltrexone-induced opiate receptor up-regulation.

1985 • 198 citations

Differential effects of leucine and methionine enkephalin on morphine-induced analgesia, acute tolerance and dependence.

1979 • 191 citations

Distribution of opiate receptor subtypes and enkephalin and dynorphin immunoreactivity in the hippocampus of squirrel, guinea pig, rat, and hamster

1987 • 180 citations

beta-FNA binds irreversibly to the opiate receptor complex: in vivo and in vitro evidence.

1988 • 123 citations

Dynorphin interaction at the κ-opiate site

1981 • 111 citations

Opiate receptor binding—enhancement by opiate administration in vivo

1976 • 104 citations

Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

1980 • 102 citations

Covalent labeling of opioid receptors with radioiodinated human beta-endorphin. Identification of binding site subunit.

1985 • 100 citations

Species differences in the concentrations and distributions of opioid binding sites

1985 • 99 citations

beta-endorphin-(1-27) is an antagonist of beta-endorphin analgesia.

1984 • 90 citations

Morphine tolerance increases μ-noncompetative δ binding sites

1986 • 88 citations

Supersensitivity of brain opiate receptor subtypes after chronic naltrexone treatment

1982 • 87 citations

Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone.

1984 • 83 citations

Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment

1985 • 79 citations

Antagonism by naloxone of narcotic-induced respiratory depression and analgesia.

1978 • 77 citations

A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site.

1985 • 75 citations

Endogenous Opioids and Their Receptorsa

1986 • 71 citations

Differences in Binding Properties of μ and δ Opioid Receptor Subtypes from Rat Brain: Kinetic Analysis and Effects of Ions and Nucleotides

1985 • 66 citations

Multiple opiate receptors: phylogenetic differences

1981 • 63 citations

Binding surface analysis: an intuitive yet quantitative method for the design and analysis of ligand binding studies.

1985 • 63 citations

Chronic administration of morphine and naltrexone up-regulate[3H][d-ala2,d-leu5]enkephalin binding sites by different mechanisms

1988 • 61 citations

Autoradiographic evidence for two classes of mu opioid binding sites in rat brain using [125I]FK33824

1987 • 58 citations

Allosteric modulation by leucine-enkephalin of [3H]naloxone binding in rat brain

1981 • 57 citations

Probes for narcotic receptor mediated phenomena. 12. cis-(+)-3-Methylfentanyl isothiocyanate, a potent site-directed acylating agent for .delta. opioid receptors. Synthesis, absolute configuration, and receptor enantioselectivity

1986 • 53 citations

Reversible and irreversible binding of beta-funaltrexamine to mu, delta and kappa opioid receptors in guinea pig brain membranes.

1986 • 53 citations

Are there subtypes (isoreceptors) of multiple opiate receptors in the mouse vas deferens?

1981 • 43 citations

High and low affinity opioid binding sites: Relationship to mu and delta sites

1982 • 40 citations

Selective and enantiospecific acylation of .kappa.-opioid receptors by (1S,2S)-trans-2-isothiocyanato-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide. Demonstration of .kappa. receptor heterogeneity

1989 • 40 citations

Mu antagonist properties of kappa agonists in a model of rat urinary bladder motility in vivo.

1987 • 39 citations

Activity of mu- and delta-selective opioid agonists in the guinea pig ileum preparation: differentiation into peptide and nonpeptide classes with beta-funaltrexamine.

1986 • 36 citations

Preparation of rat brain membranes highly enriched with opiate kappa binding sites using site-directed acylating agents: Optimization of assay conditions

1985 • 35 citations

Chronic morphine upregulates a μ-opiate binding site labeled by [3H]cycloFOXY: a novel opiate antagonist suitable for positron emission tomography

1987 • 34 citations

Heterogeneous distribution and upregulation of μ, δ and κ opioid receptors in the amygdala

1987 • 34 citations

Effect of β-FNA on opiate receptor binding: Preliminary evidence for two types of μ receptors

1983 • 34 citations

Leucine enkephalin noncompetitively inhibits the binding of [3H]naloxone to the opiate mu-recognition site: Evidence for delta←mu binding site interactions in vitro

1985 • 32 citations

Binding characteristics of kappa opioids in rat brain

1985 • 23 citations

LY164929: a highly selective ligand for the lower affinity [3H]D-Ala2-D-Leu-5-enkephalin binding site

1988 • 20 citations

Evaluation of the interactions of mu and delta selective ligands with [3H]D-ala2-D-Leu5-enkephalin binding to mouse brain membranes

1983 • 18 citations

Difference between μ-receptors in the guinea pig ileum and the mouse vas deferens

1983 • 16 citations

Differential antagonism of mu agonists by U50,488H in the rat

1987 • 15 citations

Tritiated-6-beta-fluoro-6-desoxy-oxymorphone 〈[3H] FOXY〉: a new ligand and photoaffinity probe for the MU opioid receptors

1988 • 11 citations

Biphasic competition between opiates and enkephalins: Does it indicate the existence of a common high affinity (“MU-1”) binding site?

1987 • 7 citations