Morphine tolerance increases μ-noncompetative δ binding sites

The pharmacological basis of therapeutics

1981 • 2,853 citations

Opiate Receptor: Demonstration in Nervous Tissue

1973 • 2,364 citations

Stereospecific Binding of the Potent Narcotic Analgesic [ ³ H]Etorphine to Rat-Brain Homogenate

1973 • 1,055 citations

Simultaneous quantitative assessment of morphine tolerance and physical dependence.

1969 • 681 citations

Stereospecific Interaction Between Narcotic Analgesics and a Synaptic Plasma Membrane Fraction of Rat Cerebral Cortex

1973 • 650 citations

Evidence for the Neuropeptide Cholecystokinin as an Antagonist of Opiate Analgesia

1983 • 582 citations

Quantitative aspects of precipitated abstinence in morphine-dependent rats.

1973 • 252 citations

Mu and delta receptors: Their role in analgesia and in the differential effects of opioid peptides on analgesia

1982 • 233 citations

Inhibition of spontaneous and opiate-modified nociception by an endogenous neuropeptide with Phe-Met-Arg-Phe-NH2-like immunoreactivity.

1984 • 213 citations

Repeated electroconvulsive shocks and the brain content of endorphins

1979 • 179 citations

A General Theory of the Genesis of Drug Dependence by Induction of Receptors

1965 • 149 citations

Allosteric coupling between morphine and enkephalin receptors in vitro.

1982 • 116 citations

Inhibition of morphine tolerance and physical dependence development and brain serotonin synthesis by cycloheximide

1969 • 116 citations

Dynorphin interaction at the κ-opiate site

1981 • 111 citations

Irreversible Ligands with High Selectivity Toward δ and μ Opiate Receptors

1983 • 108 citations

Repeated electroconvulsive shock or chronic morphine treatment increases the number of 3HDALA2, DLEU5enkephalin binding sites in rat brain membranes

1982 • 106 citations

The increased efficacy of narcotic antagonists induced by various narcotic analgesics.

1974 • 105 citations

Opiate receptor binding—enhancement by opiate administration in vivo

1976 • 104 citations

Opiate and peptide interaction: Effect of enkephalins on morphine analgesia

1980 • 102 citations

Visualization of opiate receptor upregulation by light microscopy autoradiography.

1984 • 97 citations

Morphine allosterically modulates the binding of [3H]leucine enkephalin to a particulate fraction of rat brain.

1982 • 91 citations

Antagonism of morphine-induced analgesia, tolerance and dependence by alpha-melanocyte-stimulating hormone.

1984 • 83 citations

Increased analgesic potency of morphine and increased brain opioid binding sites in the rat following chronic naltrexone treatment

1985 • 79 citations

A quantitative study of [3H]D-Ala2-D-Leu5-enkephalin binding to rat brain membranes. Evidence that oxymorphone is a noncompetitive inhibitor of the lower affinity delta-binding site.

1985 • 75 citations

Endogenous Opioids and Their Receptorsa

1986 • 71 citations

Repeated electroconvulsive shock (ECS) and morphine tolerance: Demonstration of cross-sensitivity in the rat

1981 • 71 citations

Preparation of rat brain membranes greatly enriched with either type-I-delta or type-II-delta opiate binding sites using site directed alkylating agents: Evidence for a two-site allosteric model

1984 • 57 citations

The anticonvulsant effects of dadle are primarily mediated by activation of δ opioid receptors: Interactions between δ and μ receptor antagonists

1985 • 48 citations

Analysis of binding surfaces: A methodology appropriate for the investigation of complex receptor mechanisms and multiple neurotransmitter receptors

1983 • 19 citations

Review and overview of four decades of opiate research.

1979 • 18 citations

Evidence that the delta-selective alkylating agent, FIT, alters the mu-noncompetitive opiate delta binding site

1985 • 16 citations

Inhibition of protein and RNA synthesis by 5-mercaptopyridoxine

1976 • 4 citations