Cell Cycle Withdrawal, Progression, and Cell Survival Regulation by EGFR and Its Effectors in the Differentiating Drosophila Eye

The development of Drosophila melanogaster

1994 • 3,057 citations

DEVELOPMENT IN DROSOPHILA MELANOGASTER

1927 • 2,909 citations

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

Growth factor signaling by receptor tyrosine kinases

1992 • 1,450 citations

An evolutionarily conserved function of the Drosophila insulin receptor and insulin-like peptides in growth control

2001 • 1,206 citations

Self-perpetuating states in signal transduction: positive feedback, double-negative feedback and bistability

2002 • 1,107 citations

Expression of baculovirus P35 prevents cell death in Drosophila

1994 • 1,037 citations

Minutes: Mutants of Drosophila autonomously affecting cell division rate

1975 • 940 citations

Molecular interpretation of ERK signal duration by immediate early gene products

2002 • 914 citations

Reiterative Use of the EGF Receptor Triggers Differentiation of All Cell Types in the Drosophila Eye

1996 • 879 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine Proteases

2001 • 561 citations

Neuronal differentiation in the Drosophila ommatidium

1987 • 532 citations

Senseless, a Zn Finger Transcription Factor, Is Necessary and Sufficient for Sensory Organ Development in Drosophila

2000 • 509 citations

The Drosophila phosphoinositide 3-kinase Dp110 promotes cell growth.

1996 • 492 citations

The Drosophila Gene hid Is a Direct Molecular Target of Ras-Dependent Survival Signaling

1998 • 477 citations

Site-Specific Recombination Between Homologous Chromosomes in Drosophila

1991 • 389 citations

POLYPEPTIDE GROWTH FACTORS

1984 • 381 citations

Ras Promotes Cell Survival in Drosophila by Downregulating hid Expression

1998 • 378 citations

In situ immunodetection of activated caspase-3 in apoptotic neurons in the developing nervous system

1998 • 366 citations

Regulated Intracellular Ligand Transport and Proteolysis Control EGF Signal Activation in Drosophila

2001 • 358 citations

Polypeptide Growth Factors: Roles In Normal And Abnormal Cell Growth

1987 • 339 citations

PTEN affects cell size, cell proliferation and apoptosis during Drosophila eye development

1999 • 316 citations

The ETS domain protein pointed-P2 is a target of MAP kinase in the sevenless signal transduction pathway

1994 • 315 citations

Cell determination strategies in the Drosophila eye

1997 • 308 citations

Regulation of imaginal disc cell size, cell number and organ size by Drosophila class IA phosphoinositide 3-kinase and its adaptor

1999 • 299 citations

Ectopic expression of activated Ras1 induces hyperplastic growth and increased cell death in Drosophila imaginal tissues

1998 • 295 citations

Receptor tyrosine kinases

1992 • 271 citations

The maternal ventralizing locus torpedo is allelic to faint little ball, an embryonic lethal, and encodes the Drosophila EGF receptor homolog

1989 • 268 citations

Combinatorial Signaling in the Specification of Unique Cell Fates

2000 • 260 citations

Guidance of Cell Migration by EGF Receptor Signaling During Drosophila Oogenesis

2001 • 254 citations

Determination of Neuronal Cell Fate: Lessons from the R7 Neuron of Drosophila

1994 • 245 citations

A family of Rhomboid intramembrane proteases activates all Drosophila membrane-tethered EGF ligands

2002 • 233 citations

The Ras signaling pathway in Drosophila

1995 • 226 citations

The Drosophila rolled locus encodes a MAP kinase required in the sevenless signal transduction pathway.

1994 • 219 citations

Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins.

1996 • 218 citations

Synergistic action of Drosophila cyclins A and B during the G2-M transition.

1993 • 211 citations

Regulation of Cell Number by MAPK-Dependent Control of Apoptosis

2002 • 190 citations

The EGF Receptor Defines Domains of Cell Cycle Progression and Survival to Regulate Cell Number in the Developing Drosophila Eye

2001 • 189 citations

ZLocal induction of patterning and programmed cell death in the developing Drosophila retina

1998 • 180 citations

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling

2000 • 177 citations

Evolution of proneural atonal expression during distinct regulatory phases in the developing Drosophila eye

1996 • 176 citations

A pathway of signals regulating effector and initiator caspases in the developingDrosophilaeye

2002 • 175 citations

Dissecting the roles of the Drosophila EGF receptor in eye development and MAP kinase activation

1998 • 170 citations

EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm

1996 • 170 citations

Receptor Tyrosine Kinases

2000 • 165 citations

Interactions between Ras1, dMyc, and dPI3K signaling in the developing Drosophila wing

2002 • 160 citations

Overlapping Activators and Repressors Delimit Transcriptional Response to Receptor Tyrosine Kinase Signals in the Drosophila Eye

2000 • 157 citations

mus304 encodes a novel DNA damage checkpoint protein required during Drosophila development

2000 • 131 citations

The Drosophila TGFα homolog Spitz acts in photoreceptor recruitment in the developing retina

1997 • 124 citations

Several Levels of EGF Receptor Signaling during Photoreceptor Specification in Wild-Type,Ellipse,and Null MutantDrosophila

1999 • 122 citations

Cis-regulatory elements of the mitotic regulator, string/Cdc25

1999 • 118 citations

Delta/Notch and Boss/Sevenless Signals Act Combinatorially to Specify the Drosophila R7 Photoreceptor

2001 • 117 citations

phyllopod functions in the fate determination of a subset of photoreceptors in drosophila

1995 • 114 citations

Ras controls growth, survival and differentiation in the Drosophila eye by different thresholds of MAP kinase activity.

2001 • 112 citations

The torso receptor tyrosine kinase can activate raf in a ras-independent pathway

1995 • 111 citations

Building a cellular switch: more lessons from a good egg

1999 • 111 citations

Comparison of dose-response curves for alpha factor-induced cell division arrest, agglutination, and projection formation of yeast cells. Implication for the mechanism of alpha factor action.

1983 • 111 citations

A Cell-Autonomous, Ubiquitous Marker for the Analysis of Drosophila Genetic Mosaics

1994 • 108 citations

Cell proliferation, survival, and death in the Drosophila eye

2001 • 108 citations

Control of drosophila photoreceptor cell fates by phyllopod, a novel nuclear protein acting downstream of the raf kinase

1995 • 106 citations

Developmental and molecular characterization of mutations in the Drosophila-raf serine/threonine protein kinase

1993 • 105 citations

R7 photoreceptor specification requires Notch activity

2000 • 101 citations

Pointed, an ETS domain transcription factor, negatively regulates the EGF receptor pathway in Drosophila oogenesis

1996 • 95 citations

Regulation of EGF receptor signaling establishes pattern across the developing Drosophila retina

1998 • 90 citations

Requirement for EGF receptor signalling in neural recruitment during formation of Drosophila chordotonal sense organ clusters

1997 • 79 citations

Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage

2002 • 75 citations

Pointed and Tramtrack69 establish an EGFR-dependent transcriptional switch to regulate mitosis

2002 • 75 citations

Role of the EGFR/Ras/Raf pathway in specification of photoreceptor cells in the Drosophila retina

2001 • 72 citations

Functional analysis of CNK in RAS signaling

1999 • 64 citations

Notch Activation of yan Expression Is Antagonized by RTK/Pointed Signaling in the Drosophila Eye

2002 • 63 citations

Molecular analysis of the Drosophila EGF receptor homolog reveals that several genetically defined classes of alleles cluster in subdomains of the receptor protein.

1994 • 63 citations

Undifferentiated cells in the developing Drosophila eye influence facet assembly and require the Fat facets ubiquitin-specific protease

1996 • 60 citations

Relative Dependence of Different Outputs of the Saccharomyces cerevisiae Pheromone Response Pathway on the MAP Kinase Fus3p

1999 • 58 citations

Negative regulation of atonal in proneural cluster formation of Drosophila R8 photoreceptors

1999 • 52 citations

Signal transduction and cell fate specification during Caenorhabditis elegans vulval development

1994 • 51 citations

Argos induces programmed cell death in the developing Drosophila eye by inhibition of the Ras pathway

1998 • 47 citations

Graded mode of transcriptional induction in yeast pheromone signalling revealed by single‐cell analysis

2001 • 46 citations

Genetic dissection of signal transduction mediated by the sevenless receptor tyrosine kinase in Drosophila

1994 • 26 citations