Keren, a new ligand of the Drosophila epidermal growth factor receptor, undergoes two modes of cleavage

Analysis of genetic mosaics in developing and adult Drosophila tissues

1993 • 2,029 citations

MEMBRANE-ANCHORED GROWTH FACTORS

1993 • 676 citations

The Drosophila dorsoventral patterning gene gurken produces a dorsally localized RNA and encodes a TGF alpha-like protein.

1993 • 567 citations

Drosophila Rhomboid-1 Defines a Family of Putative Intramembrane Serine Proteases

2001 • 561 citations

Feedback control of intercellular signalling in development

2000 • 535 citations

Polarization of both major body axes in Drosophila by gurken-torpedo signalling

1995 • 485 citations

cornichon and the EGF receptor signaling process are necessary for both anterior-posterior and dorsal-ventral pattern formation in Drosophila

1995 • 480 citations

rhomboid, a gene required for dorsoventral axis establishment and peripheral nervous system development in Drosophila melanogaster.

1990 • 389 citations

In Situ Activation Pattern of Drosophila EGF Receptor Pathway During Development

1997 • 372 citations

Regulated Intracellular Ligand Transport and Proteolysis Control EGF Signal Activation in Drosophila

2001 • 358 citations

The Drosophila rhomboid gene mediates the localized formation of wing veins and interacts genetically with components of the EGF-R signaling pathway.

1993 • 320 citations

Secreted Spitz triggers the DER signaling pathway and is a limiting component in embryonic ventral ectoderm determination.

1995 • 312 citations

The Drosophila spitz gene encodes a putative EGF-like growth factor involved in dorsal-ventral axis formation and neurogenesis.

1992 • 278 citations

Sprouty is a general inhibitor of receptor tyrosine kinase signaling

1999 • 261 citations

A thousand and one roles for the Drosophila EGF receptor

1997 • 250 citations

An Autoregulatory Cascade of EGF Receptor Signaling Patterns the Drosophila Egg

1998 • 247 citations

A group of genes required for pattern formation in the ventral ectoderm of the Drosophila embryo.

1988 • 238 citations

The Drosophila embryonic midline is the site of Spitz processing, and induces activation of the EGF receptor in the ventral ectoderm

1996 • 232 citations

Vein is a novel component in the Drosophila epidermal growth factor receptor pathway with similarity to the neuregulins.

1996 • 218 citations

7 EGF Receptor Signaling in Drosophila Oogenesis

1998 • 206 citations

A family of rhomboid-like genes: Drosophila rhomboid-1 and roughoid/rhomboid-3 cooperate to activate EGF receptor signaling

2000 • 177 citations

EGF receptor signaling induces pointed P1 transcription and inactivates Yan protein in the Drosophila embryonic ventral ectoderm

1996 • 170 citations

rhomboid and Star interact synergistically to promote EGFR/MAPK signaling during Drosophila wing vein development

1999 • 139 citations

The Drosophila TGFα homolog Spitz acts in photoreceptor recruitment in the developing retina

1997 • 124 citations

Characterization of Star and its interactions with sevenless and EGF receptor during photoreceptor cell development in Drosophila

1994 • 123 citations

Intracellular trafficking by Star regulates cleavage of the Drosophila EGF receptor ligand Spitz

2002 • 116 citations

Sequential activation of the EGF receptor pathway during Drosophila oogenesis establishes the dorsoventral axis

1998 • 112 citations

TheDrosophila kekkonGenes: Novel Members of both the Leucine-Rich Repeat and Immunoglobulin Superfamilies Expressed in the CNS

1996 • 109 citations

A primary role for the epidermal growth factor receptor in ommatidial spacing in the Drosophila eye

2001 • 92 citations

Rhomboid and Star facilitate presentation and processing of the Drosophila TGF-alpha homolog Spitz.

2000 • 84 citations

Localization of the DER/flb protein in embryos: implications on the faint little ball lethal phenotype

1990 • 82 citations

The transmembrane region of Gurken is not required for biological activity, but is necessary for transport to the oocyte membrane in Drosophila

1999 • 78 citations

Mechanism of activation of theDrosophilaEGF Receptor by the TGFα ligand Gurken during oogenesis

2002 • 75 citations

Vein expression is induced by the EGF receptor pathway to provide a positive feedback loop in patterning the Drosophila embryonic ventral ectoderm

1999 • 61 citations

EGF domain swap converts a Drosophila EGF receptor activator into an inhibitor

1998 • 59 citations

Role of the EGF receptor pathway in growth and patterning of the Drosophila wing through the regulation of vestigial

1999 • 45 citations

The Role of Star in the Production of an Activated Ligand for the EGF Receptor Signaling Pathway

1999 • 39 citations

Characterization of a mammalian cDNA encoding a protein with high sequence similarity to the Drosophila regulatory protein Rhomboid

1998 • 38 citations