Pattern of Apolipoprotein E Immunoreactivity During Brain Aging

Gene Dose of Apolipoprotein E Type 4 Allele and the Risk of Alzheimer's Disease in Late Onset Families

1993 • 8,888 citations

The Consortium to Establish a Registry for Alzheimer's Disease (CERAD)

1991 • 4,669 citations

Apolipoprotein E: high-avidity binding to beta-amyloid and increased frequency of type 4 allele in late-onset familial Alzheimer disease.

1993 • 4,145 citations

Apolipoprotein E: Cholesterol Transport Protein with Expanding Role in Cell Biology

1988 • 3,984 citations

Association of apolipoprotein E allele ϵ4 with late‐onset familial and sporadic Alzheimer's disease

1993 • 3,693 citations

Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease

1994 • 1,813 citations

Increased amyloid beta-peptide deposition in cerebral cortex as a consequence of apolipoprotein E genotype in late-onset Alzheimer disease.

1993 • 1,480 citations

Binding of human apolipoprotein E to synthetic amyloid beta peptide: isoform-specific effects and implications for late-onset Alzheimer disease.

1993 • 1,329 citations

Apolipoprotein E immunoreactivity in cerebral amyloid deposits and neurofibrillary tangles in Alzheimer's disease and kuru plaque amyloid in Creutzfeldt-Jakob disease

1991 • 1,133 citations

Apolipoprotein E in sporadic Alzheimer's disease: Allelic variation and receptor interactions

1993 • 1,092 citations

Apolipoprotein E: A pathological chaperone protein in patients with cerebral and systemic amyloid

1992 • 802 citations

Apolipoprotein E associated with astrocytic glia of the central nervous system and with nonmyelinating glia of the peripheral nervous system.

1985 • 786 citations

Apolipoprotein E in animal models of CNS injury and in alzheimer's disease

1994 • 651 citations

Expression of apolipoprotein E during nerve degeneration and regeneration.

1986 • 563 citations

Apolipoprotein E ∈4 allele distributions in late-onset Alzheimer's disease and in other amyloid-forming diseases

1993 • 504 citations

Apolipoprotein E mRNA is abundant in the brain and adrenals, as well as in the liver, and is present in other peripheral tissues of rats and marmosets.

1985 • 500 citations

Isoform-specific interactions of apolipoprotein E with microtubule-associated protein tau: implications for Alzheimer disease.

1994 • 453 citations

Hypothesis: Microtubule Instability and Paired Helical Filament Formation in the Alzheimer Disease Brain Are Related to Apolipoprotein E Genotype

1994 • 427 citations

Astrocytic apolipoprotein E mRNA and GFAP mRNA in hippocampus after entorhinal cortex lesioning

1991 • 386 citations

Distribution of the ?2-macroglobulin receptor/low density lipoprotein receptor-related protein in human tissues

1992 • 385 citations

Perineuronal nets provide a polyanionic, glia‐associated form of microenvironment around certain neurons in many parts of the rat brain

1993 • 341 citations

Cholesterol synthesis and lipoprotein reuptake during synaptic remodelling in hippocampus in adult rats

1993 • 334 citations

Neuropathological changes in scrapie and Alzheimer's disease are associated with increased expression of apolipoprotein E and cathepsin D in astrocytes

1991 • 297 citations

Apolipoproteins in human cerebrospinal fluid.

1979 • 282 citations

Nerve injury stimulates the secretion of apolipoprotein E by nonneuronal cells.

1986 • 253 citations

Effects of apolipoprotein E, beta-very low density lipoproteins, and cholesterol on the extension of neurites by rabbit dorsal root ganglion neurons in vitro.

1992 • 199 citations

Apolipoprotein E Is Localized to the Cytoplasm of Human Cortical Neurons: A Light and Electron Microscopic Study

1994 • 195 citations

Denervated sheath cells secrete a new protein after nerve injury.

1983 • 181 citations

Lactotransferrin immunocytochemistry in Alzheimer and normal human brain.

1993 • 167 citations

Apolipoprotein E Is Present in Hippocampal Neurons without Neurofibrillary Tangles in Alzheimer's Disease and in Age-Matched Controls

1994 • 153 citations

Apolipoprotein E localization in rat hepatocytes by immunogold labeling of cryothin sections

1990 • 150 citations

A Specific 37,000-Dalton Protein That Accumulates in Regenerating but Not in Nonregenerating Mammalian Nerves

1985 • 144 citations

Mapping of perineuronal nets in the rat brain stained by colloidal iron hydroxide histochemistry and lectin cytochemistry

1994 • 139 citations

The iron-binding protein lactotransferrin is present in pathologic lesions in a variety of neurodegenerative disorders: a comparative immunohistochemical analysis

1994 • 129 citations

Immunoreactive apolipoprotein E is a widely distributed cellular protein. Immunohistochemical localization of apolipoprotein E in baboon tissues.

1986 • 116 citations

Senile plaques and neurofibrillary changes in the brain of an aged lemurian primate, Microcebus murinus

1992 • 111 citations

Apolipoprotein E4 and beta amyloid in senile plaques and cerebral blood vessels of aged rhesus monkeys.

1994 • 92 citations

Cloning of hippocampal poly(A) RNA sequences that increase after entorhinal cortex lesion in adult rat

1991 • 90 citations

Immunohistochemical study of α2 Macroglobulin receptor in Alzheimer and control postmortem human brain

1993 • 70 citations

Apolipoprotein E-immunoreactivity in aged rhesus monkey cortex: Colocalization with amyloid plaques

1994 • 58 citations

Immunocytochemical characterization of Tau proteins during cerebral aging of the lemurian primate Microcebus murinus.

1995 • 58 citations

Macrophage Apolipoprotein Synthesis and Endoneurial Distribution as a Response to Segmental Demyelination

1991 • 25 citations

THE BRIDGE IN GALL-BLADDER SURGERY

1944 • 1 citations