Activation of the N-Ras–PI3K–Akt-mTOR Pathway by Hepatitis C Virus: Control of Cell Survival and Viral Replication

Lipid rafts and signal transduction

2000 • 6,079 citations

Upstream and downstream of mTOR

2004 • 4,085 citations

Replication of Subgenomic Hepatitis C Virus RNAs in a Hepatoma Cell Line

1999 • 2,796 citations

Phosphatidylinositol-3-OH kinase direct target of Ras

1994 • 1,923 citations

Efficient Initiation of HCV RNA Replication in Cell Culture

2000 • 1,412 citations

Survival signalling by Akt and eIF4E in oncogenesis and cancer therapy

2004 • 945 citations

PI 3-kinase, Akt and cell survival

2004 • 767 citations

Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent initiation of translation.

1996 • 671 citations

Identification of the Hepatitis C Virus RNA Replication Complex in Huh-7 Cells Harboring Subgenomic Replicons

2003 • 615 citations

Pathogens: raft hijackers

2003 • 471 citations

The dark side of Ras: regulation of apoptosis

2003 • 430 citations

Oncogenic Ras and Akt Signaling Contribute to Glioblastoma Formation by Differential Recruitment of Existing mRNAs to Polysomes

2003 • 412 citations

Lipids as Targeting Signals: Lipid Rafts and Intracellular Trafficking

2004 • 361 citations

Characterization of Cell Lines Carrying Self-Replicating Hepatitis C Virus RNAs

2001 • 358 citations

Persistent and Transient Replication of Full-Length Hepatitis C Virus Genomes in Cell Culture

2002 • 357 citations

Activation of translation complex eIF4F is essential for the genesis and maintenance of the malignant phenotype in human mammary epithelial cells

2004 • 335 citations

Phosphorylation of hepatitis C virus nonstructural protein 5A modulates its protein interactions and viral RNA replication

2004 • 323 citations

Cholesterol-rich lipid rafts mediate akt-regulated survival in prostate cancer cells.

2002 • 319 citations

Epstein-Barr Virus Latent Membrane Protein 1 (LMP1) Activates the Phosphatidylinositol 3-Kinase/Akt Pathway to Promote Cell Survival and Induce Actin Filament Remodeling

2003 • 280 citations

Hepatitis C Virus RNA Replication Occurs on a Detergent-Resistant Membrane That Cofractionates with Caveolin-2

2003 • 263 citations

Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts

2004 • 261 citations

The Hepatitis C Virus NS5A Protein Activates a Phosphoinositide 3-Kinase-dependent Survival Signaling Cascade

2004 • 219 citations

Epstein–Barr virus (EBV) LMP2A mediates B-lymphocyte survival through constitutive activation of the Ras/PI3K/Akt pathway

2004 • 200 citations

Global and Specific Translational Control by Rapamycin in T Cells Uncovered by Microarrays and Proteomics

2002 • 192 citations

The Hepatitis B Virus-X Protein Activates a Phosphatidylinositol 3-Kinase-dependent Survival Signaling Cascade

2001 • 181 citations

Subversion of Cell Signaling Pathways by Hepatitis C Virus Nonstructural 5A Protein via Interaction with Grb2 and P85 Phosphatidylinositol 3-Kinase

2002 • 176 citations

Reduction of Hepatitis C Virus NS5A Hyperphosphorylation by Selective Inhibition of Cellular Kinases Activates Viral RNA Replication in Cell Culture

2004 • 148 citations

Do lipid rafts mediate virus assembly and pseudotyping?

2003 • 122 citations

Escaping from the Cell: Assembly and Budding of Negative-Strand RNA Viruses

2004 • 119 citations

Lipid Rafts and Assembly of Enveloped Viruses

2002 • 103 citations

HIV-1-Tat Protein Activates Phosphatidylinositol 3-Kinase/ AKT-dependent Survival Pathways in Kaposi's Sarcoma Cells

2002 • 97 citations

Postgenomic global analysis of translational control induced by oncogenic signaling

2004 • 88 citations

Lipid raft microdomains: key sites for Coxsackievirus A9 infectious cycle

2003 • 75 citations

An Altered Cellular Response to Interferon and Up-Regulation of Interleukin-8 Induced by the Hepatitis C Viral Protein NS5A Uncovered by Microarray Analysis

2002 • 71 citations

Analysis of the interaction between respiratory syncytial virus and lipid-rafts in Hep2 cells during infection

2004 • 67 citations

High-Throughput Screening of the Yeast Kinome: Identification of Human Serine/Threonine Protein Kinases That Phosphorylate the Hepatitis C Virus NS5A Protein

2004 • 67 citations

Rotavirus infectious particles use lipid rafts during replication for transport to the cell surface in vitro and in vivo

2003 • 64 citations

Evidence of a Role for Phosphatidylinositol 3-Kinase Activation in the Blocking of Apoptosis by Polyomavirus Middle T Antigen

1998 • 62 citations

The Raft-Promoting Property of Virion-Associated Cholesterol, but Not the Presence of Virion-Associated Brij 98 Rafts, Is a Determinant of Human Immunodeficiency Virus Type 1 Infectivity

2004 • 62 citations

Modulation of phosphoinositide 3‐kinase activation by cholesterol level suggests a novel positive role for lipid rafts in lysophosphatidic acid signalling

2003 • 57 citations

Measles Virus Interacts with and Alters Signal Transduction in T-Cell Lipid Rafts

2004 • 51 citations