Atopic disorders: a default pathway in the absence of infection?

Functional diversity of helper T lymphocytes

1996 • 4,512 citations

Association of Asthma with Serum IgE Levels and Skin-Test Reactivity to Allergens

1989 • 1,689 citations

Flexible Programs of Chemokine Receptor Expression on Human Polarized T Helper 1 and 2 Lymphocytes

1998 • 1,574 citations

Cytokines Induce the Development of Functionally Heterogeneous T Helper Cell Subsets

1998 • 1,569 citations

Lymphokine Production by Human T Cells in Disease States

1994 • 1,351 citations

The Inverse Association Between Tuberculin Responses and Atopic Disorder

1997 • 1,305 citations

Selective Expression of the Eotaxin Receptor CCR3 by Human T Helper 2 Cells

1997 • 1,073 citations

Regulation of the Interleukin (IL)-12R β2 Subunit Expression in Developing T Helper 1 (Th1) and Th2 Cells

1997 • 1,022 citations

Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells.

1990 • 954 citations

Development of allergen-specific T-cell memory in atopic and normal children

1999 • 925 citations

Anti-proliferative effect of IFN-gamma in immune regulation. I. IFN-gamma inhibits the proliferation of Th2 but not Th1 murine helper T lymphocyte clones.

1988 • 845 citations

Induction of TH1 and TH2 responses: a key role for the ‘natural’ immune response?

1992 • 794 citations

Induction of NK activity in murine and human cells by CpG motifs in oligodeoxynucleotides and bacterial DNA.

1996 • 764 citations

CYTOKINE REGULATION OF HOST DEFENSE AGAINST PARASITIC GASTROINTESTINAL NEMATODES:Lessons from Studies with Rodent Models^*

1997 • 648 citations

Interleukin 12 inhibits antigen-induced airway hyperresponsiveness, inflammation, and Th2 cytokine expression in mice.

1995 • 626 citations

Measles and atopy in Guinea-Bissau

1996 • 598 citations

Increasing prevalence of hay fever and atopy among children in Leipzig, East Germany

1998 • 582 citations

Modulation of airway inflammation by CpG oligodeoxynucleotides in a murine model of asthma.

1998 • 557 citations

Prevalence of asthma and allergic disorders among children in united Germany: a descriptive comparison.

1992 • 530 citations

Cross sectional retrospective study of prevalence of atopy among Italian military students with antibodies against hepatitis a virus

1997 • 529 citations

Increase in asthma: a more toxic environment or a more susceptible population?

1994 • 483 citations

IL-4 and IFN (alpha and gamma) exert opposite regulatory effects on the development of cytolytic potential by Th1 or Th2 human T cell clones.

1992 • 430 citations

Increased expression of eotaxin in bronchoalveolar lavage and airways of asthmatics contributes to the chemotaxis of eosinophils to the site of inflammation.

1997 • 419 citations

Cutting Edge: Modulation of Airway Inflammation by CpG Oligodeoxynucleotides in a Murine Model of Asthma

1998 • 416 citations

Infection of Mice with Mycobacterium bovis–Bacillus Calmette-Guérin (BCG) Suppresses Allergen-induced Airway Eosinophilia

1998 • 404 citations

CD4+ effector cells default to the Th2 pathway in interferon gamma-deficient mice infected with Leishmania major.

1994 • 397 citations

Expression of eotaxin by human lung epithelial cells: induction by cytokines and inhibition by glucocorticoids.

1997 • 369 citations

Respiratory syncytial virus infection results in airway hyperresponsiveness and enhanced airway sensitization to allergen.

1997 • 335 citations

Human Th1 and Th2 lymphocytes: their role in the pathophysiology of atopy

1992 • 280 citations

IL-4-induced immune deviation as antigen-specific therapy for inflammatory autoimmune disease

1996 • 270 citations

BCG infection suppresses allergic sensitization and development of increased airway reactivity in an animal model☆☆☆★★★

1998 • 241 citations

Mucosal IFN-gamma gene transfer inhibits pulmonary allergic responses in mice.

1996 • 207 citations

Nebulized IFN-gamma inhibits the development of secondary allergic responses in mice.

1996 • 206 citations

Asthma prevalence in Tokelauan children in two environments

1980 • 204 citations

TH2-polarized immunological memory to inhalant allergens in atopics is established during infancy and early childhood.

1997 • 200 citations

Transcription Factors in Lymphocyte Development— T and B Cells Get Together

1999 • 169 citations

Clinical Improvement of Asthma after Anthelminthic Treatment in a Tropical Situation

1997 • 162 citations

TH₂‐polarized immunological memory to inhalant allergens in atopies is established during infaney and early childhood

1997 • 149 citations

Relationship between allergic manifestations and Toxocara seropositivity: a cross-sectional study among elementary school children

1997 • 149 citations

T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophila.

1996 • 126 citations

Overexpression of interleukin-4 delays virus clearance in mice infected with respiratory syncytial virus

1997 • 113 citations

Allergic sensitisation of human lung fragments prevented by saturation of IgE binding sites

1976 • 101 citations

IgE, allergies and helminth parasites: A new perspective on an old conundrum

1996 • 101 citations

Possible explanation for the different trends of asthma and allergy in east and west Germany

1996 • 80 citations

Eosinophils are not required to induce airway hyperresponsiveness after nematode infection

1998 • 60 citations

Parasite-induced ‘nonspecific’ IgE does not protect against allergic reactions

1980 • 56 citations

Increase in CD23+ B Cells in Infants with Bronchiolitis Is Accompanied by Appearance of IgE and IgG4 Antibodies Specific for Respiratory Syncytial Virus

1997 • 52 citations

The role of Th2 type CD4⁺ T cells and Th2 type CD8⁺ T cells in asthma

1996 • 45 citations

Association between pronounced IgA response in RSV bronchiolitis and development of allergic sensitization

1997 • 43 citations

IFN-gamma prevents Th2 cell-mediated pathology after neonatal injection of semiallogenic spleen cells in mice.

1994 • 40 citations

Susceptibility to Leishmania major in IL‐4 transgenic mice is not correlated with the lack of a Th1 immune response

1996 • 20 citations

Suppression of Allergic Reactivity by Intestinal Helminths: Susceptibility Is a Function of IgE Responder Phenotype

1985 • 8 citations