GABAB receptor: a site of therapeutic benefit

GABAB-receptor subtypes assemble into functional heteromeric complexes

1998 • 1,163 citations

Heterodimerization is required for the formation of a functional GABAB receptor

1998 • 1,156 citations

GABAB receptors function as a heteromeric assembly of the subunits GABABR1 and GABABR2

1998 • 1,054 citations

Intrathecal Baclofen for Severe Spinal Spasticity

1989 • 700 citations

International Union of Pharmacology. XXXIII. Mammalian gamma -Aminobutyric AcidB Receptors: Structure and Function

2002 • 588 citations

Epilepsy, Hyperalgesia, Impaired Memory, and Loss of Pre- and Postsynaptic GABAB Responses in Mice Lacking GABAB(1)

2001 • 531 citations

Evolving Concepts on the Pathophysiology of Absence Seizures

2005 • 435 citations

Don't worry ‘B’ happy!: a role for GABAB receptors in anxiety and depression

2004 • 405 citations

GABA and its receptors in the spinal cord

1996 • 304 citations

Epileptogenesis and Enhanced Prepulse Inhibition in GABAB1-Deficient Mice

2001 • 278 citations

Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501.

2001 • 242 citations

Redistribution of GABA_B(1)Protein and Atypical GABA_BResponses in GABA_B(2)-Deficient Mice

2004 • 217 citations

GABA_B2 Is Essential for G-Protein Coupling of the GABA_B Receptor Heterodimer

2001 • 211 citations

The Heptahelical Domain of GABAB2 Is Activated Directly by CGP7930, a Positive Allosteric Modulator of the GABAB Receptor

2004 • 200 citations

Upregulation of gamma-aminobutyric acid (GABA) B binding sites in rat frontal cortex: a common action of repeated administration of different classes of antidepressants and electroshock.

1985 • 197 citations

SGS742: the first GABAB receptor antagonist in clinical trials

2004 • 185 citations

N,N′-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and Structurally Related Compounds: Novel Allosteric Enhancers of γ-Aminobutyric Acid_B Receptor Function

2003 • 184 citations

GABAB receptor antagonists: potential new anti-absence drugs

1992 • 140 citations

Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits

2005 • 131 citations

Baclofen inhibits more effectively C-afferent than Aδ-afferent glutamatergic transmission in substantia gelatinosa neurons of adult rat spinal cord slices

2000 • 123 citations

Pharmacology of absence epilepsy

2003 • 120 citations

GABAB receptor antagonist SGS742 improves spatial memory and reduces protein binding to the cAMP response element (CRE) in the hippocampus

2005 • 112 citations

The GABAB Receptor-Positive Modulator GS39783 and the GABAB Receptor Agonist Baclofen Attenuate the Reward-Facilitating Effects of Cocaine: Intracranial Self-Stimulation Studies in the Rat

2005 • 111 citations

Repeated Administration of the GABAB Receptor Agonist CGP44532 Decreased Nicotine Self-Administration, and Acute Administration Decreased Cue-Induced Reinstatement of Nicotine-Seeking in Rats

2004 • 106 citations

Combined lesions of cholinergic and serotonergic neurons in the rat brain using 192 IgG‐saporin and 5,7‐dihydroxytryptamine: neurochemical and behavioural characterization

2000 • 100 citations

Single- and Multilocus Allelic Variants within the GABAB Receptor Subunit 2 (GABAB2) Gene Are Significantly Associated with Nicotine Dependence

2005 • 99 citations

Effects of positive allosteric modulators of the GABA B receptor on cocaine self-administration in rats

2004 • 98 citations

Role of gamma-aminobutyric acid in antipanic drug efficacy

1989 • 93 citations

Baclofen, a selective GABAB receptor agonist, dose-dependently impairs spatial learning in rats

1996 • 91 citations

A New Approach to Control Central Deafferentation Pain: Spinal Intrathecal Baclofen

1995 • 80 citations

GABAB receptor alterations as indicators of physiological and pharmacological function

2004 • 77 citations

Tiagabine antinociception in rodents depends on GABAB receptor activation: parallel antinociception testing and medial thalamus GABA microdialysis

1999 • 71 citations

Baclofen reduces fat intake under binge-type conditions

2005 • 67 citations

Presynaptic regulation of spinal cord tachykinin signaling via GABA B but not GABA A receptor activation

2001 • 63 citations

Spinal cord SP release and hyperalgesia in monoarthritic rats: involvement of the GABA_B receptor system

1994 • 61 citations

Intrathecal Baclofen after Traumatic Brain Injury: Early Treatment Using a New Technique to Prevent Spasticity

2001 • 60 citations

Activation of muscarinic receptors inhibits spinal dorsal horn projection neurons: role of GABAB receptors

2004 • 57 citations

Effects of chronic oral administration of the antidepressants, desmethylimipramine and zimelidine on rat cortical GABA_B binding sites: a comparison with 5‐HT₂ binding site changes

1988 • 55 citations

Are increases in GABAB receptors consistent findings following chronic antidepressant administration?

1987 • 53 citations

Spasticity : a topical survey

1972 • 43 citations

Panicolytic-like effect induced by the stimulation of GABAA and GABAB receptors in the dorsal periaqueductal grey of rats

2005 • 42 citations

The GABAB2 subunit is critical for the trafficking and function of native GABAB receptors

2004 • 42 citations

Interaction between gamma-aminobutyric acid GABAB and cannabinoid CB1 receptors in spinal pain pathways in rat

2005 • 36 citations

Administration of baclofen, a γ‐aminobutyric acid type B agonist in the thalamic ventrobasal complex, attenuates allodynia in monoarthritic rats subjected to the ankle‐bend test

2006 • 33 citations

Chronic nicotine and smoke treatment modulate dopaminergic activities in ventral tegmental area and nucleus accumbens and the ?-aminobutyric acid type B receptor expression of the rat prefrontal cortex

2004 • 33 citations

Effects of the GABAB receptor agonists baclofen and 3-aminopropylphosphinic acid (3-APA) on food intake in rats

2004 • 23 citations