Interfacial catalysis by phospholipase A2: evaluation of the interfacial rate constants by steady-state isotope effect studies

How is the level of free arachidonic acid controlled in mammalian cells?

1982 • 1,193 citations

INTERFACIAL ENZYME KINETICS OF LIPOLYSIS

1976 • 573 citations

Structure and function of phospholiphase A2

1981 • 478 citations

Use of Hydrogen Isotope Effects to Identify the Attacking Nucleophile in the Enolization of Ketones Catalyzed by Acetic Acid^1-3

1958 • 343 citations

Phospholipase A2 and its zymogen from porcine pancreas. VII. Zymogen-catalyzed hydrolysis of monomeric substrates and the presence of a recognition site for lipid-water interfaces in phospholipase A2

1974 • 271 citations

The kinetics of interfacial catalysis by phospholipase A2 and regulation of interfacial activation: hopping versus scooting

1989 • 261 citations

Kinetic analysis of the dual phospholipid model for phospholipase A2 action.

1984 • 135 citations

Kinetics of interfacial catalysis by phospholipase A2 in intravesicle scooting mode, and heterofusion of anionic and zwitterionic vesicles

1986 • 119 citations

[4] Determination of heavy-aton isotope effects on enzyme-catalyzed reactions

1980 • 116 citations

Heavy-atom isotope effects on the alkaline hydrolysis and hydrazinolysis of methyl benzoate

1979 • 111 citations

Phospholipase A₂ mechanism: Inhibition and role in arachidonic acid release

1987 • 98 citations

Competitive inhibition of phospholipase A2 in vesicles

1989 • 87 citations

Synthesis of nucleotides with specific radiolabels in ribose. Primary 14C and secondary 3H kinetic isotope effects on acid-catalyzed glycosidic bond hydrolysis of AMP, dAMP, and inosine.

1984 • 80 citations

Synthesis and evaluation of phospholipid analogs as inhibitors of cobra venom phospholipase A2

1987 • 80 citations

Phospholipid transfer between phosphatidylcholine-taurocholate mixed micelles

1988 • 66 citations

MULTIPLE ISOTOPE EFFECTS ON ENZYME-CATALYZED REACTIONS

1989 • 65 citations

Kinetic Isotope Effects in Enzymology

1978 • 62 citations

Affinity chromatography of phospholipase A2 from Naja naja naja (Indian cobra) venom

1985 • 46 citations

Kinetic isotope-effect probes of transition-state structure. Vibrational analysis of model transition states for carbonyl addition

1980 • 44 citations

Phospholipid synthesis by extracellular phospholipase A2 in organic solvents

1990 • 42 citations

Enzymic hydrolysis of short-chain lecithin/long-chain phospholipid unilamellar vesicles: sensitivity of phospholipases to matrix phase state

1987 • 30 citations

Rate-determining step in phospholipase A2 mechanism. 18O isotope exchange determined by 13C NMR.

1986 • 18 citations

Application of a novel double-labeling procedure to measurement of carbonyl oxygen isotope effects on the alkaline hydrolysis and hydrazinolysis of methyl benzoate

1978 • 14 citations

Heavy-atom isotope effects on the acid-catalyzed hydrolysis of methyl benzoate

1981 • 11 citations