Pre-term labor: an intra-uterine inflammatory response syndrome?

Definitions for Sepsis and Organ Failure and Guidelines for the Use of Innovative Therapies in Sepsis

1992 • 12,726 citations

Potential antiinflammatory effects of interleukin 4: suppression of human monocyte tumor necrosis factor alpha, interleukin 1, and prostaglandin E2.

1989 • 741 citations

Infection and labor

1989 • 600 citations

Infection and labor

1992 • 593 citations

Interleukin-6 concentrations in umbilical cord plasma are elevated in neonates with white matter lesions associated with periventricular leukomalacia

1996 • 587 citations

Amniotic fluid interleukin 6 in preterm labor. Association with infection.

1990 • 557 citations

Amniotic fluid interleukin-6: A sensitive test for antenatal diagnosis of acute inflammatory lesions of preterm placenta and prediction of perinatal morbidity

1995 • 494 citations

A comparative study of the diagnostic performance of amniotic fluid glucose, white blood cell count, interleukin-6, and Gram stain in the detection of microbial invasion in patients with preterm premature rupture of membranes

1993 • 409 citations

The Preterm Labor Syndrome

1994 • 403 citations

Interleukin‐1α and Interleukin‐1 β in Preterm and Term Human Parturition

1992 • 390 citations

The diagnostic and prognostic value of amniotic fluid white blood cell count, glucose, interleukin-6, and Gram stain in patients with preterm labor and intact membranes

1993 • 379 citations

Tumor necrosis factor in preterm and term labor

1992 • 370 citations

Neutrophil attractant/activating peptide-1 / interleukin-8 in term and preterm parturition

1991 • 353 citations

Premature Labor and Intra-Amniotic Infection: Clinical Aspects and Role of the Cytokines in Diagnosis and Pathophysiology

1995 • 345 citations

Human placental cytotrophoblasts produce the immunosuppressive cytokine interleukin 10.

1996 • 343 citations

An experimental model for intraamniotic infection and preterm labor in rhesus monkeys

1994 • 341 citations

Systemic administration of interleukin-1 induces preterm parturition in mice

1991 • 333 citations

Cachectin/tumor necrosis factor-alpha formation in human decidua. Potential role of cytokines in infection-induced preterm labor.

1989 • 307 citations

Systemic and local cytokine profiles in endotoxin-induced preterm parturition in mice

1994 • 244 citations

Amniotic fluid interleukin-6: Correlation with upper genital tract microbial colonization and gestational age in women delivered after spontaneous labor versus indicated delivery

1995 • 241 citations

Interleukin-6 stimulates prostaglandin production by human amnion and decidual cells

1991 • 232 citations

Human decidua: a source of interleukin-1.

1989 • 221 citations

The natural interleukin-1 receptor antagonist prevents interleukin-l-induced preterm delivery in mice

1992 • 212 citations

Preterm birth prevention: Where are we?

1993 • 209 citations

Elevation of amniotic fluid interleukin 6 (IL-6), IL-8 and granulocyte colony stimulating factor (G-CSF) in term and preterm parturition

1993 • 190 citations

Neutrophil attractant/activating peptide-1/interleukin-8: Association with histologic chorioamnionitis, preterm delivery, and bioactive amniotic fluid leukoattractants

1993 • 155 citations

Interleukin-Iβ Intra-Amniotic Infusion Induces TUmor Necrosis Factor-α, Prostaglandin Production, and Preterm COntractions in Pregnant Rhesus Monkeys

1996 • 155 citations

Choriodecidual production of interleukin-8 and mechanism of parturition

1992 • 153 citations

Interleukin-8 production by the human cervix

1993 • 148 citations

Amniotic fluid interleukin-6 levels correlate with histologic chorioamnionitis and amniotic fluid cultures in patients in premature labor with intact membranes

1993 • 148 citations

Inflammatory cytokine (interleukins 1, 6, and 8 and tumor necrosis factor-α) release from cultured human fetal membranes in response to endotoxic lipopolysaccharide mirrors amniotic fluid concentrations

1996 • 146 citations

Prostaglandins and Parturition^a

1997 • 144 citations

A model of intrauterine infection and preterm delivery in mice

1995 • 143 citations

Prostaglandins and parturition

1995 • 139 citations

Repeated administration of low-dose lipopolysaccharide induces preterm delivery in mice: A model for human preterm parturition and for assessment of the therapeutic ability of drugs against preterm delivery

1996 • 138 citations

Decidual cell biosynthesis of interleukin-6: regulation by inflammatory cytokines

1992 • 134 citations

Inflammatory cytokine mRNA in human gestational tissues: Implications for term and preterm labor

1996 • 132 citations

Expression of inflammatory cytokines (interleukin-1β and interleukin-6) in amniochorionic membranes

1995 • 129 citations

Localization of tumour necrosis factor production in cells at the materno/fetal interface in human pregnancy

1992 • 121 citations

Inflammatory mediators regulate interleukin-8 production by cultured gestational tissues: evidence for a cytokine network at the chorio-decidual interface.

1993 • 114 citations

Amniotic fluid interleukin-10 concentrations increase through pregnancy and are elevated in patients with preterm labor associated with intrauterine infection

1995 • 113 citations

Macrophage Inflammatory Protein‐1α in Term and Preterm Parturtition: Effect of Microbial Invasion of the Amniotic Cavity

1994 • 112 citations

Suppression of interleukin 8 production by progesterone in rabbit uterine cervix

1994 • 112 citations

Cytokine measurements and interpretation of cytokine assays in human disease

1994 • 107 citations

Human Placenta Constitutively Produces Interleukin-8 during Pregnancy and Enhances its Production in Intrauterine Infection1

1992 • 104 citations

Transforming growth factor-β2 prevents preterm delivery induced by interleukin-α and tumor necrosis factor-α the rabbit

1993 • 103 citations

Lipopolysaccharide-Induced Fetal Death: The Role of Tumor-Necrosis Factor Alpha1

1994 • 102 citations

Elevated Placental Cytokine Release, a Process Associated With Preterm Labor in the Absence of Intrauterine Infection

1996 • 101 citations

Interleukin-10 messenger ribonucleic acid in human placenta: Implications of a role for interleukin-10 in fetal allograft protection

1995 • 89 citations

Amniotic fluid tumor necrosis factor-α and interleukin-1 in a rabbit model of bacterially induced preterm pregnancy loss

1992 • 87 citations

A rabbit model for bacteria-induced preterm pregnancy loss

1990 • 87 citations

Interleukin-10 in amniotic fluid at midtrimester: Immune activation and suppression in relation to fetal growth

1994 • 82 citations

Interleukin-8 induces cervical ripening in rabbits

1994 • 81 citations

Tumour necrosis factor a during human pregnancy and labour: maternal plasma and amniotic fluid concentrations and release from intrauterine tissues

1994 • 71 citations

Interleukin-I? intra-amniotic infusion induces tumor necrosis factor-?, prostaglandin production, and preterm contractions in pregnant rhesus monkeys

1996 • 70 citations

Clinical value of amniotic fluid interleukin‐6 determinations in the management of preterm labour

1994 • 67 citations

Placental interleukin-6 production is enhanced in intrauterine infection but not in labor

1993 • 64 citations

Interleukin-10 inhibition of interleukin-6 in human amniochorionic membrane: Transcriptional regulation

1996 • 64 citations

Elevations of Amniotic Fluid Macrophage Inflammatory Protein-1α Concentrations in Women During Term and Preterm Labor

1996 • 62 citations

Expression of Interleukin-10 in Human Gestational Tissues

1997 • 62 citations

Cytokine expression in the placenta. The role of interleukin 1 and interleukin 1 receptor antagonist expression in chorioamnionitis and parturition.

1994 • 62 citations

Amniotic fluid interleukin-10 (IL-10) concentrations during pregnancy and with labor

1997 • 61 citations

Amnion cell biosynthesis of interleukin‐8: Regulation by inflammatory cytokines

1992 • 60 citations

Infection, Inflammation, and Contractions: The Role of Cytokines in the Pathophysiology of Preterm Labor

1994 • 58 citations

Biosynthesis of interleukin-6 by cultured human chorion laeve cells: regulation by cytokines.

1992 • 57 citations

Treatment With the Interleukin-1 Receptor Antagonist and Soluble Tumor Necrosis Factor Receptor Fc Fusion Protein Does Not Prevent Endotoxin-Induced Preterm Parturition in Mice

1997 • 56 citations

Expression on cells of early human pregnancy decidua, of the p75, IL-2 and p145, IL-4 receptor proteins.

1991 • 55 citations

Transforming growth factor-β opposes the stimulatory effects of interleukin-1 and tumor necrosis factor on amnion cell prostaglandin E2 production: Implication for preterm labor

1992 • 53 citations

Detection and localization of interleukin-8 mRNA and protein in human placenta and decidual tissues

1994 • 52 citations

The national impact of ritodrine hydrochloride for inhibition of preterm labor.

1990 • 52 citations

Inflammatory mediators regulate interleukin-8 production by cultured gestational tissues: evidence for a cytokine network at the chorio- decidual interface

1993 • 52 citations

Differential release of interleukin-6 from human gestational tissues in association with labour and in vitro endotoxin treatment

1996 • 50 citations

The transfer of interleukin-8 across the human placenta perfused in vitro

1996 • 47 citations

Elevation of Amniotic Fluid Interleukin-4 Concentrations in Women with Preterm Labor and Chorioamnionitis

1996 • 47 citations

Constitutive Secretion of Interleukin‐6 by Human Decidual Stromal Cells in Culture. Regulatory Effect of Progesterone

1995 • 44 citations

Regulation of Human Decidual Cell Macrophage Inflammatory Protein‐1α (MIP‐1α) Production by Inflammatory Cytokines

1995 • 44 citations

Regulation of decidual cell chemokine production by group B streptococci and purified bacterial cell wall components

1997 • 43 citations

Regulation of Decidual Cell and Chorion Cell Production of Interleukin‐10 by Purified Bacterial Products

1997 • 40 citations

The induction of cyclooxygenase-2 (COX-2) in intact human amnion tissue by interleukin-4

1996 • 39 citations

Amniotic fluid Interleukin-8 as a marker for intraamniotic infection

1993 • 38 citations

Biosynthesis of interleukin-6 by cultured human chorion laeve cells: regulation by cytokines

1992 • 34 citations

Regulation of Cultured Human Chorion Cell Chemokine Production by Group B Streptococci and Purified Bacterial Products

1996 • 33 citations

Actions of interleukin-4 on prostaglandin biosynthesis at the chorion-decidual interface

1993 • 26 citations

Amniotic Fluid Interleukin-6 and Interleukin-8 Levels Predict the Success of Tocolysis in Patients With Preterm Labor

1994 • 26 citations

Treatment with the interleukin-I receptor antagonist and soluble tumor necrosis factor receptor fc fusion protein does not prevent endotoxin-induced preterm parturition in mice

1997 • 25 citations

Actions of interleukin-4 on prostaglandin biosynthesis by human amnion cells

1994 • 19 citations

Second-trimester amniotic fluid or maternal serum interleukin-10 levels and small for gestational age neonates

1996 • 19 citations

Cytokine production by human fetal membranes and uterine decidua at term gestation in relation to labour

1993 • 18 citations

The Mouse as an Investigational Model for Preterm Labor

1994 • 4 citations