On the Molecular Bases of the Specificity of Interaction of Transcriptional Proteins with Genome DNA

Genetic regulatory mechanisms in the synthesis of proteins

1961 • 6,378 citations

Some Factors in the Interpretation of Protein Denaturation

1959 • 4,817 citations

Theoretical aspects of DNA-protein interactions: Co-operative and non-co-operative binding of large ligands to a one-dimensional homogeneous lattice

1974 • 2,905 citations

Repeated Sequences in DNA

1968 • 2,836 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Ion effects on ligand-nucleic acid interactions

1976 • 1,016 citations

Contribution of Hydrophobic Interactions to the Stability of the Globular Conformation of Proteins

1962 • 986 citations

lac repressor-operator interaction

1970 • 791 citations

Current Models of Steroid Hormone Action: A Critique

1976 • 707 citations

Lac represser-operator interaction

1973 • 699 citations

Steroid Receptors: Elements for Modulation of Eukaryotic Transcription

1976 • 688 citations

MINIATURE escherichia coli CELLS DEFICIENT IN DNA

1967 • 629 citations

The Selectivity of Transcription

1974 • 539 citations

DNA-Protein Interactions

1972 • 412 citations

Restriction Endonuclease

1976 • 405 citations

Macromolecular binding

1975 • 364 citations

Diffusion controlled reaction rates in spheroidal geometry

1974 • 344 citations

Nucleic Acid-Protein Recognition

1977 • 343 citations

The general affinity of lac repressor for E. coli DNA: Implications for gene regulation in procaryotes and eucaryotes

1975 • 341 citations

Least-squares refinement of the crystal and molecular structures of DNA and RNA from X-ray data and standard bond lengths and angles

1969 • 311 citations

Theoretical calculations of the helix-coil transition of DNA in the presence of large, cooperatively binding ligands

1976 • 307 citations

lac repressor—Operator interaction

1970 • 279 citations

Nonspecific interaction of lac repressor with DNA: an association reaction driven by counterion release

1977 • 262 citations

Interactions between twisted DNAs and enzymes: The effects of superhelical turns

1974 • 258 citations

The properties of repressor and the kinetics of its action

1965 • 257 citations

Interpretation of monovalent and divalent cation effects on the lac repressor-operator interaction

1977 • 251 citations

Non-specific DNA Binding of Genome Regulating Proteins as a Biological Control Mechanism: 1. The lac Operon: Equilibrium Aspects

1974 • 242 citations

On the Relation between Effector Concentration and the Rate of Induced Enzyme Synthesis

1971 • 216 citations

Alteration of the Relative Stability of dA·dT and dG·dC Base Pairs in DNA

1973 • 212 citations

Structure and Conformation of Nucleic Acids and Protein-Nucleic Acid Interactions

1976 • 209 citations

Model for DNA and Protein Interactions and the Function of the Operator

1966 • 197 citations

DNA "melting" proteins. IV. Fluorescence measurements of binding parameters for bacteriophage T4 gene 32-protein to mono-, oligo-, and polynucleotides.

1976 • 192 citations

Lac repressor and Lac operator

1976 • 187 citations

Interaction of effecting ligands with lac repressor and repressor-operator complex

1975 • 181 citations

Nonspecific interactions of Escherichia coli RNA polymerase with native and denatured DNA: differences in the binding behavior of core and holoenzyme

1978 • 163 citations

Direct measurement of association constants for the binding of Escherichia coli lac repressor to non-operator DNA

1977 • 160 citations

Nonspecific DNA binding of genome-regulating proteins as a biological control mechanism: Measurement of DNA-bound Escherichia coli lac repressor in vivo

1977 • 160 citations

Measurements of unwinding of lac operator by repressor

1974 • 158 citations

The Stereochemistry of Actinomycin Binding to DNA and Its Implications in Molecular Biology

1973 • 151 citations

Structure and conformation of nucleic acids and protein-nucleic acid interactions

1975 • 148 citations

Association kinetics with coupled diffusional flows

1976 • 146 citations

The interaction of estradiol-receptor protein with the genome: an argument for the existence of undetected specific sites

1975 • 144 citations

The nature of Lactose operator constitutive mutations

1971 • 141 citations

The Role of Cyclic AMP in Bacteria

1971 • 141 citations

Contacts between the lac repressor and the thymines in the lac operator.

1977 • 132 citations

Repressors

1976 • 132 citations

Specific binding of CAP factor to lac promoter DNA

1975 • 125 citations

Starting and Stopping Sequences for the RNA Polymerase

1976 • 119 citations

Nucleic acid binding properties of Escherichia coli ribosomal protein S1

1978 • 109 citations

Recombination of DNA Molecules

1966 • 107 citations

Recognition of Nucleotide Sequences

1969 • 106 citations

Physicochemical properties of DNA binding proteins. Gene 32 protein of T4 and Escherichia coli unwinding protein

1975 • 106 citations

Equilibrium and kinetic studies of Escherichia coli lac repressor-inducer interactions

1972 • 105 citations

Specific recognition of single-stranded nucleic acids. Interaction of tryptophan-containing peptides with native, denatured, and ultraviolet-irradiated DNA.

1977 • 102 citations

Molecular parameters characterizing the interaction of Escherichia coli lac repressor with non-operator DNA and inducer

1977 • 95 citations

DNA "melting" proteins. III. Fluorescence "mapping" of the nucleic acid binding site of bacteriophage T4 gene 32-protein.

1976 • 85 citations

lac Repressor-operator interaction

1974 • 84 citations

How lac repressor recognizes lac operator.

1978 • 83 citations

The conformation dependent hydrolysis of DNA by micrococcal nuclease

1968 • 78 citations

Binding of synthetic lactose operator DNAs to lactose repressors

1977 • 75 citations

Structure of gene 5 protein-oligodeoxynucleotide complexes as determined by proton, ¹⁹F, and ³¹P nuclear magnetic resonance

1976 • 72 citations

Minimal length of the lactose operator sequence for the specific recognition by the lactose repressor.

1977 • 70 citations

Cooperative Multisite Binding to DNA

1974 • 61 citations

High resolution electron microscopic studies of genetic regulation

1976 • 61 citations

Symmetry in Protein-Nucleic Acid Interaction and Its Genetic Implications

1973 • 59 citations

Lac Repressor. Fluorescence of the two tryptophans.

1976 • 51 citations

Mapping of the lactose operator

1971 • 48 citations

Escherichia coli ribosomal protein S1 has two polynucleotide binding sites.

1977 • 47 citations

Interaction of lac repressor with inducer. Kinetic and equilibrium measurements

1977 • 43 citations

Electron microscope studies of transient complexes formed between Escherichia coli RNA polymerase holoenzyme and T7 DNA.

1977 • 43 citations

lac repressor-operator interaction. Analysis of the X86 repressor mutant

1976 • 43 citations

A comparison of lac repressor binding to operator and to nonoperator DNA

1975 • 42 citations

Interaction of RNA Polymerase with the DNA Template

1976 • 41 citations

Lactose Operator Sequences and the Action of Lac Repressor

1975 • 39 citations

Binding of E.coli lac repressor to non-operator DNA

1977 • 36 citations

An unusual lac repressor mutant

1970 • 32 citations

A boundary sedimentation velocity method for determining nonspecific nucleic acid-protein interaction binding parameters

1977 • 32 citations

Complexes of Escherichia coli lac-repressor with non-operator DNA revealed by electron microscopy: Two represser molecules can share the same segment of DNA

1977 • 30 citations

The transmission of stability or instability from site specific protein-DNA complexes

1977 • 28 citations

Conformational transitions of the lac repressor from Escherichia coli

1976 • 26 citations

Interaction of Lac Repressor with Non-Specific DNA Binding Sites

1975 • 21 citations

Molecular Approaches to the Interaction of Nucleic Acids with “Melting” Proteins

1977 • 11 citations

The Use of Suppressed Nonsense Mutations to Generate Altered Lac Repressor Molecules

1975 • 2 citations