The replication initiator protein of plasmid pSC101 is a transcriptional repressor of its own cistron.

The pUC plasmids, an M13mp7-derived system for insertion mutagenesis and sequencing with synthetic universal primers

1982 • 6,153 citations

DNAase footprinting a simple method for the detection of protein-DNA binding specificity

1978 • 2,092 citations

Procedure for the rapid, large-scale purification of Escherichia coli DNA-dependent RNA polymerase involving polymin P precipitation and DNA-cellulose chromatography

1975 • 1,157 citations

Evidence for two functional gal promoters in intact Escherichia coli cells.

1981 • 1,022 citations

Partitioning of bacterial plasmids during cell division: a cis-acting locus that accomplishes stable plasmid inheritance

1980 • 335 citations

Replication control in a composite plasmid constructed by in vitro linkage of two distinct replicons

1976 • 246 citations

Recircularization and Autonomous Replication of a Sheared R-Factor DNA Segment in Escherichia coli Transformants

1973 • 198 citations

Revised Interpretation of the Origin of the pSC101 Plasmid

1977 • 188 citations

Characterization of the Autoregulation of Simian Virus 40 Gene A

1977 • 168 citations

Rapid purification of a cloned gene product by genetic fusion and site-specific proteolysis.

1984 • 159 citations

Interaction of the plasmid R6K-encoded replication initiator protein with its binding sites on DNA

1983 • 136 citations

Replication of plasmid pSC101 inEscherichia coli K12: Requirement fordnaA function

1977 • 130 citations

Regulation of the dnaA product in Escherichia coli

1977 • 107 citations

Primary structure of the essential replicon of the plasmid pSC101.

1983 • 92 citations

The nucleotide sequence of replication and maintenance functions encoded by plasmid PSCl0l

1983 • 91 citations

DNA-protein interaction at the origin of DNA replication of the plasmid pSC101

1983 • 85 citations

Use of gene fusions and protein-protein interaction in the isolation of a biologically active regulatory protein: the replication initiator protein of plasmid R6K.

1983 • 84 citations