Locus assignment of alpha-globin structural mutations by hybrid-selected translation.

Detection of specific sequences among DNA fragments separated by gel electrophoresis

1975 • 33,059 citations

[57] Sequencing end-labeled DNA with base-specific chemical cleavages

1980 • 15,302 citations

An Efficient mRNA‐Dependent Translation System from Reticulocyte Lysates

1976 • 3,994 citations

Atlas of Protein Sequence and Structure, 1966.

1967 • 1,463 citations

Prolonged incubation in calcium chloride improves the competence of Escherichia coli cells

1979 • 1,454 citations

Human fetal gγ- and Aγ-globin genes: Complete nucleotide sequences suggest that DNA can be exchanged between these duplicated genes

1980 • 947 citations

A Specific Chemical Difference Between the Globins of Normal Human and Sickle-Cell Anæmia Hæmoglobin

1956 • 858 citations

Structural gene identification and mapping by DNA-mRNA hybrid-arrested cell-free translation.

1977 • 543 citations

Rapid duplication and loss of genes coding for the alpha chains of hemoglobin.

1980 • 531 citations

The chromosomal arrangement of human α-like globin genes: Sequence homology and α-globin gene deletions

1980 • 531 citations

Gene conversion: Some implications for immunoglobulin genes

1981 • 496 citations

THE ORGANIZATION, EXPRESSION, AND EVOLUTION OF ANTIBODY GENES AND OTHER MULTIGENE FAMILIES

1975 • 446 citations

α-Thalassaemia caused by a polyadenylation signal mutation

1983 • 407 citations

An improved method for the fingerprinting of human hemoglobin

1961 • 350 citations

Insertion of synthetic copies of human globin genes into bacterial plasmids

1978 • 350 citations

Structural Studies of Aminoethylated Hemoglobins by Automatic Peptide Chromatography

1964 • 332 citations

Mouse beta 2-microglobulin cDNA clones: a screening procedure for cDNA clones corresponding to rare mRNAs.

1981 • 320 citations

Haemoglobin Constant Spring—A Chain Termination Mutant ?

1971 • 305 citations

Hemoglobin: Molecular, genetic and clinical aspects

1987 • 248 citations

Homology and concerted evolution at the α1 and α2 loci of human α-globin

1981 • 207 citations

Identification of a Nondeletion Defect in α-Thalassemia

1977 • 194 citations

Boundaries of gene conversion within the duplicated human alpha-globin genes. Concerted evolution by segmental recombination.

1983 • 185 citations

Organization of the alpha-globin genes in the Chinese alpha-thalassemia syndromes.

1979 • 183 citations

The duplicated human alpha globin genes lie close together in cellular DNA.

1978 • 177 citations

Reselution of hemoglobin subunits by electrophoresis in acid urea polyacrylamide gels containing Triton X-100

1978 • 156 citations

Differentiation of the mRNA transcripts originating from the alpha 1- and alpha 2-globin loci in normals and alpha-thalassemics.

1981 • 141 citations

Globin structural mutant α125Leu→Pro is a novel cause of α-thalassaemia

1982 • 141 citations

Cloning and complete nucleotide sequence of human 5'-alpha-globin gene.

1980 • 136 citations

Evolution of the 87A and 87C heat-shock loci in Drosophila

1981 • 127 citations

The duplicated human α-globin genes: Their relative expression as measured by RNA analysis

1981 • 123 citations

Abnormal RNA splicing causes one form of α thalassemia

1982 • 120 citations

Translationally associated helix-destabilizing activity in rabbit reticulocyte lysate.

1984 • 111 citations

The 3′ untranslated regions of the duplicated human α-globin genes are unexpectedly divergent

1980 • 106 citations

Regulation of Synthesis of Non-Globin Proteins in Cell-free Extracts of Rabbit Reticulocytes

1973 • 105 citations

Haemoglobin Icaria, a new chain-termination mutant which causes α thalassaemia

1974 • 104 citations

Construction and identification by positive hybridization-translation of a bacterial plasmid containing a rat growth hormone structural gene sequence

1978 • 93 citations

Gene conversion of two functional goat alpha-globin genes preserves only minimal flanking sequences.

1982 • 93 citations

GENE CONVERSION AND TRANSFER OF GENETIC INFORMATION WITHIN THE INVERTED REGION OF INVERSION HETEROZYGOTES

1973 • 93 citations

Hemoglobin Wayne: a frameshift mutation detected in human hemoglobin alpha chains.

1976 • 68 citations

alpha-Thalassemia caused by an unstable alpha-globin mutant.

1983 • 62 citations

A New Hæmoglobin—Ja Oxford Found During a Survey of an English Population

1964 • 61 citations

Gγ and Aγ globin chains separation and quantitation by isoelectric focusing

1979 • 57 citations

Haemoglobin J Tongariki is associated with α thalassaemia

1978 • 50 citations

Trimodality in the proportion of hemoglobin G Philadelphia in heterozygotes: evidence for heterogeneity in the number of human alpha chain loci.

1976 • 50 citations

The G gamma:A gamma composition of fetal hemoglobin in fetuses and newborns

1979 • 45 citations

MULTIPLE HEMOGLOBIN α‐CHAIN LOCI IN MONKEYS, APES, AND MAN *

1974 • 41 citations

Structural and evolutionary analysis of the two chimpanzee α-globin mRNAs

1983 • 41 citations

Proportion of hemoglobin G Philadelphia (alpha 268 Asn leads to Lys beta 2) in heterozygotes is determined by alpha-globin gene deletions.

1980 • 37 citations

Different rates of mRNA translation balance the expression of the two human alpha-globin loci.

1982 • 36 citations

Linkage of alpha G-Philadelphia to alpha-thalassemia in African-Americans .

1980 • 31 citations

Hemoglobin hasharon (alpha-47 aspartic acid--histidine).

1967 • 15 citations

a-Thalassemia Caused by an Unstable a-Globin Mutant

1983 • 12 citations

Cloning and complete nucleotide sequence of human 5′-α-globin gene

1981 • 6 citations

Beta thalassemia in Sardinia in the result of a nonsense mutation.

1981 • 5 citations