Significance of DNA adduct studies in animal models for cancer molecular dosimetry and risk assessment.

IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans

1980 • 3,166 citations

Structural identification of the major DNA adduct formed by aflatoxin B1 in vitro.

1977 • 507 citations

Correlation of DNA adduct levels in human lung with cigarette smoking

1988 • 310 citations

Detection of Smoking-Related Covalent DNA Adducts in Human Placenta

1986 • 261 citations

Hemoglobin adducts of 4-aminobiphenyl in smokers and nonsmokers.

1987 • 259 citations

Preparation of the 8,9-epoxide of the mycotoxin aflatoxin B1: the ultimate carcinogenic species

1988 • 241 citations

Metabolic Activation and DNA Adducts of Aromatic Amines and Nitroaromatic Hydrocarbons

1990 • 239 citations

Smoking related carcinogen-DNA adducts in biopsy samples of human urinary bladder: identification of N-(deoxyguanosin-8-yl)-4-aminobiphenyl as a major adduct.

1991 • 211 citations

Dose-response relationship between O6-methylguanine formation in Clara cells and induction of pulmonary neoplasia in the rat by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone.

1990 • 196 citations

Hemoglobin adducts of aromatic amines: associations with smoking status and type of tobacco.

1988 • 192 citations

Detection of benzo[a]pyrene diol epoxide-DNA adducts in peripheral blood lymphocytes and antibodies to the adducts in serum from coke oven workers.

1985 • 190 citations

Serum albumin adducts in the molecular epidemiology of aflatoxin carcinogenesis: correlation with aflatoxin B₁ intake and urinary excretion of aflatoxin M₁

1988 • 190 citations

Aflatoxin metabolism in humans: detection of metabolites and nucleic acid adducts in urine by affinity chromatography.

1985 • 185 citations

Alkylation of deoxyribonucleic acid in vivo in various organs of C57BL mice by the carcinogens N-methyl-N-nitrosourea, N-ethyl-N-nitrosourea and ethyl methanesulphonate in relation to induction of thymic lymphoma. Some applications of high-pressure liquid chromatography

1978 • 177 citations

Detection of polycyclic aromatic hydrocarbon-DNA adducts in white blood cells of foundry workers.

1988 • 170 citations

Determination of polycyclic aromatic hydrocarbons in the urine, benzo(a)pyrene diol epoxide-DNA adducts in lymphocyte DNA, and antibodies to the adducts in sera from coke oven workers exposed to measured amounts of polycyclic aromatic hydrocarbons in the work atmosphere.

1986 • 167 citations

A pilot project in molecular cancer epidemiology: determination of benzo[a]pyrene — DNA adducts in animal and human tissues by immunoassays

1982 • 167 citations

0⁶‐Methyldeoxyguanosine in oesophageal dna among individuals at high risk of oesophageal cancer

1985 • 163 citations

Covalent DNA Damage in Tissues of Cigarette Smokers as Determined by 32P-Postlabeling Assay

1989 • 159 citations

Chemical carcinogens: ACS monograph 173

1977 • 135 citations

Detection of benzo(a)pyrene:DNA adducts in human white blood cells.

1985 • 130 citations

DNA Adducfs, Protein Adducts, and Sister Chromatid Exchange in Cigarette Smokers and Nonsmokers<xref ref-type="fn" rid="FN2">2</xref>

1987 • 126 citations

Quantitative Associations Between DNA Damage in Human Placenta and Maternal smoking and Birth Weight

1988 • 124 citations

Acetylation phenotype, carcinogen-hemoglobin adducts, and cigarette smoking.

1990 • 123 citations

Aflatoxin B₁ binding to plasma albumin and liver DNA upon chronic administration to rats

1986 • 121 citations

Polycyclic Aromatic Hydrocarbon Carcinogenesis

1985 • 119 citations

Optically active benzo[c]phenanthrene diol epoxides bind extensively to adenine in DNA

1987 • 116 citations

Detection of benzo[a]pyrene diol epoxide-DNA adducts in human placenta.

1988 • 104 citations

Quantitative inter-relationships between aflatoxin B1 carcinogen dose, indole-3-carbinol anti-carcinogen dose, target organ DNA adduction and final tumor response

1989 • 101 citations

In vivo dosimetry of 4-aminobiphenyl in rats via a cysteine adduct in hemoglobin.

1984 • 100 citations

Determination of Benzo[a]pyrene Diol Epoxide--DNA Adducts in White Blood Cell DNA From Coke-Oven Workers: The Impact of Smoking

1990 • 92 citations

Polycyclic aromatic hydrocarbon-DNA adducts in lung tissue from lung cancer patients

1990 • 91 citations

Tobacco as a risk factor in bladder cancer

1983 • 90 citations

Comparative 32P-analysis of cigarette smoke-induced DNA damage in human tissues and mouse skin.

1986 • 85 citations

N-Nitroso Compounds

1990 • 84 citations

Dose-response study of DNA and hemoglobin adduct formation by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in F344 rats.

1990 • 84 citations

Aflatoxin B1 carcinogenesis and its relation to DNA adduct formation and adduct persistence in sensitive and resistant salmonid fish

1988 • 82 citations

Alkyl and aryl carcinogen adducts detected in human peripheral lung

1989 • 76 citations

Mechanisms of anti-carcinogenesis by indole-3-carbinol: detailed in vivo DNA binding dose-response studies after dietary administration with aflatoxin B1

1988 • 71 citations

Detection of putative adduct with fluorescence characteristics identical to 2,3-dihydro-2-(7′-guanyl)-3-hydroxyaflatoxin B₁ in human urine collected in Murang'a district, Kenya

1983 • 71 citations

Immunological detection of aflatoxin B1-DNA adducts formed in vivo.

1988 • 67 citations

Methylated purines in human liver DNA after probable dimethylnitrosamine poisoning.

1980 • 65 citations

Characterisation of the imidazole ring-opened forms of trans-8,9-di-hydro-8-(7-guanyl)9-hydroxy aflatoxin B₁

1982 • 63 citations

Benzoαaαpyrene-induced skin damage and tumor promotion in the mouse

1991 • 63 citations

DNA adducts in bronchial biopsies

1991 • 63 citations

Linear dose-response relationship for DNA adducts in rat liver from chronic exposure to aflatoxin B₁

1990 • 62 citations

Benzoαaαpyrene diolepoxide-DNA adducts in alveolar macrophages of smokers

1991 • 60 citations

Comparison between DNA adduct formation and turmorigenesis in livers and bladders of mice chronically fed 2-acetylaminofluorence

1991 • 57 citations

Molecular dosimetry of O4-ethyldeoxythymidine in rats continuously exposed to diethylnitrosamine.

1987 • 55 citations

Gastric tumors in mice fed benzo(a)pyrene: a quantitative study.

1967 • 55 citations

Molecular dosimetry of hepatic aflatoxin B1-DNA adducts: Linear correlation with hepatic cancer risk

1989 • 54 citations

Fluorescence detection of benzo[a]pyrene-DNA adducts in human lung

1991 • 53 citations

DNA adduct formation, removal and persistance in rat liver during one month of feeding 2-acetylaminofluorene

1984 • 40 citations

Dose response of hepatocyte replication in rats following continuous exposure to diethylnitrosamine.

1989 • 37 citations

Tissue distribution and mode of DNA methylation in mice by methyl methanesulphonate and N-methyl-N′-nitro-N-nitrosoguanidine: Lack of thymic lymphoma induction and low extent of methylation of target tissue DNA at O-6 of guanine

1976 • 34 citations

Assessment of exposure and susceptibility to aromatic amine carcinogens.

1988 • 27 citations

DNA adduct determination in humans.

1991 • 21 citations

Detection in human cells of alkylated macromolecules attributable to exposure to nitrosamines.

1988 • 9 citations

Interactions of Fungal and Plant Toxins with DNA: Aflatoxins, Sterigmatocystin, Safrole, Cycasin, and Pyrrolizidine Alkaloids

1990 • 8 citations

Tissue binding of 2-acetylaminofluorene in BALB/c and C57B1/6 mice during chronic oral administration

1980 • 5 citations