Cholesterol Reduction and Stroke Occurrence: An Overview of Randomized Clinical Trials

Meta-analysis in clinical trials

1986 • 36,193 citations

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 8,631 citations

The Effect of Pravastatin on Coronary Events after Myocardial Infarction in Patients with Average Cholesterol Levels

1996 • 7,450 citations

Prevention of Coronary Heart Disease with Pravastatin in Men with Hypercholesterolemia

1995 • 7,378 citations

Prevention of Cardiovascular Events and Death with Pravastatin in Patients with Coronary Heart Disease and a Broad Range of Initial Cholesterol Levels

1998 • 5,229 citations

Helsinki Heart Study: Primary-Prevention Trial with Gemfibrozil in Middle-Aged Men with Dyslipidemia

1987 • 3,889 citations

PREVENTION OF CORONARY HEART DISEASE WITH PRAVASTATIN IN MEN WITH HYPERCHOLESTEROLEMIA

1995 • 3,524 citations

Beta blockade during and after myocardial infarction: An overview of the randomized trials

1985 • 3,248 citations

Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S)

1994 • 2,615 citations

Regression of Coronary Artery Disease as a Result of Intensive Lipid-Lowering Therapy in Men with High Levels of Apolipoprotein B

1990 • 2,192 citations

Mediterranean alpha-linolenic acid-rich diet in secondary prevention of coronary heart disease

1994 • 2,133 citations

Clofibrate and Niacin in Coronary Heart Disease

1975 • 1,660 citations

Beneficial Effects of Combined Colestipol-Niacin Therapy on Coronary Atherosclerosis and Coronary Venous Bypass Grafts

1987 • 1,651 citations

Serum Cholesterol Levels and Six-Year Mortality from Stroke in 350,977 Men Screened for the Multiple Risk Factor Intervention Trial

1989 • 1,123 citations

A co-operative trial in the primary prevention of ischaemic heart disease using clofibrate. Report from the Committee of Principal Investigators.

1978 • 1,058 citations

Effect of Partial Ileal Bypass Surgery on Mortality and Morbidity from Coronary Heart Disease in Patients with Hypercholesterolemia

1990 • 999 citations

The Effect of Aggressive Lowering of Low-Density Lipoprotein Cholesterol Levels and Low-Dose Anticoagulation on Obstructive Changes in Saphenous-Vein Coronary-Artery Bypass Grafts

1997 • 954 citations

Effect of lovastatin on early carotid atherosclerosis and cardiovascular events. Asymptomatic Carotid Artery Progression Study (ACAPS) Research Group.

1994 • 887 citations

Cholesterol, diastolic blood pressure, and stroke: 13 000 strokes in 450 000 people in 45 prospective cohorts

1995 • 852 citations

Effects on coronary artery disease of lipid-lowering diet, or diet plus cholestyramine, in the St Thomas' Atherosclerosis Regression Study (STARS)

1992 • 847 citations

Effects of Lipid Lowering by Pravastatin on Progression and Regression of Coronary Artery Disease in Symptomatic Men With Normal to Moderately Elevated Serum Cholesterol Levels

1995 • 846 citations

Regression of Coronary Atherosclerosis During Treatment of Familial Hypercholesterolemia With Combined Drug Regimens

1990 • 793 citations

Cholesterol Lowering With Statin Drugs, Risk of Stroke, and Total Mortality

1997 • 737 citations

Statins do more than just lower cholesterol

1996 • 714 citations

Reduction of Mortality in the Stockholm Ischaemic Heart Disease Secondary Prevention Study by Combined Treatment with Clofibrate and Nicotinic Acid

1988 • 693 citations

Effect of simvastatin on coronary atheroma: the Multicentre Anti-Atheroma Study (MAAS)

1994 • 648 citations

Pravastatin, lipids, and atherosclerosis in the carotid arteries (PLAC-II)

1995 • 612 citations

A Controlled Clinical Trial of a Diet High in Unsaturated Fat in Preventing Complications of Atherosclerosis

1969 • 600 citations

Kuopio Atherosclerosis Prevention Study (KAPS)

1995 • 557 citations

Effects of monotherapy with an HMG-CoA reductase inhibitor on the progression of coronary atherosclerosis as assessed by serial quantitative arteriography. The Canadian Coronary Atherosclerosis Intervention Trial.

1994 • 504 citations

Expanded Clinical Evaluation of Lovastatin (EXCEL) study results. I. Efficacy in modifying plasma lipoproteins and adverse event profile in 8245 patients with moderate hypercholesterolemia

1991 • 489 citations

Randomised controlled trial of cardioprotective diet in patients with recent acute myocardial infarction: results of one year follow up.

1992 • 468 citations

Cholesterol Reduction Yields Clinical Benefit

1998 • 462 citations

The Oslo Diet-Heart Study

1970 • 456 citations

Pravastatin limitation of atherosclerosis in the coronary arteries (PLAC I): Reduction in atherosclerosis progression and clinical events

1995 • 431 citations

Angiographic Assessment of Effects of Bezafibrate on Progression of Coronary Artery Disease in Young Male Postinfarction Patients

1996 • 415 citations

Prevention of the Angiographic Progression of Coronary and Vein-Graft Atherosclerosis by Gemfibrozil After Coronary Bypass Surgery in Men With Low Levels of HDL Cholesterol

1997 • 394 citations

Stroke, Statins, and Cholesterol

1997 • 316 citations

Serum cholesterol and hemorrhagic stroke in the Honolulu Heart Program.

1989 • 308 citations

Clofibrate and niacin in coronary heart disease

1975 • 300 citations

Lack of Effect of Lovastatin on Restenosis after Coronary Angioplasty

1994 • 291 citations

Test of effect of lipid lowering by diet on cardiovascular risk. The Minnesota Coronary Survey.

1989 • 288 citations

Cholesterol Reduction Yields Clinical Benefit

1995 • 283 citations

LDL-Apheresis Atherosclerosis Regression Study (LAARS)

1996 • 271 citations

Beneficial effects of combined colestipol-niacin therapy on coronary atherosclerosis and coronary venous bypass grafts

1987 • 231 citations

Cholesterol Reduction and the Risk for Stroke in Men

1993 • 216 citations

Reductase Inhibitor Monotherapy and Stroke Prevention

1997 • 213 citations

Colestipol hydrochloride in hypercholesterolemic patients—Effect on serum cholesterol and mortality

1978 • 208 citations

Fibrinogen and lipid concentrations as risk factors for transient ischaemic attacks and minor ischaemic strokes.

1991 • 187 citations

Regression of coronary atherosclerosis during treatment of familial hypercholesterolemia with combined drug regimens

1990 • 170 citations

Cholesterol lowering with statin drugs, risk of stroke, and total mortality. An overview of randomized trials

1997 • 162 citations

Relation between blood lipids, lipoproteins, and cerebrovascular atherosclerosis. A review.

1988 • 130 citations

An Overview of Trials of Cholesterol Lowering and Risk of Stroke

1995 • 109 citations

Efficacy of Gemfibrozil in Dyslipidaemic Subjects with Suspected Heart Disease. An Ancillary Study in the Helsinki Heart Study Frame Population

1993 • 94 citations

Risk Factors for Primary Cerebral Hemorrhage: A Population-Based Study – The Stroke Registry of Dijon

1995 • 76 citations

Controlled trial of clofibrate in cerebral vascular disease

1972 • 75 citations

Cholesterol reduction and its impact on coronary artery disease and total mortality

1995 • 61 citations

The Long-term Effects of Probucol on Serum Lipid Levels

1981 • 31 citations

An overview of trials of cholesterol lowering and risk of stroke

1995 • 30 citations

Serum Cholesterol and Risk of Ischemic Stroke: Results of a Case-Control Study

1995 • 25 citations

The long-term effects of probucol on serum lipid levels

1981 • 12 citations

Meta-analysis, clinical trials, and transferability of research results into practice. The case of cholesterol-lowering interventions in the secondary prevention of coronary heart disease

1996 • 10 citations