In vivo evidence that the rise in plasma IL 6 following injection of a fever-inducing dose of LPS is mediated by IL 1β

Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

1986 • 1,501 citations

Production of hybridoma growth factor by human monocytes

1987 • 1,133 citations

Advances in prostaglandin, thromboxane, and leukotriene research

1985 • 759 citations

Participation of tumor necrosis factor in the mediation of gram negative bacterial lipopolysaccharide-induced injury in rabbits.

1988 • 603 citations

Interleukin 6 is involved in interleukin 1‐induced activities

1988 • 422 citations

Tumor necrosis factor and interleukin-1β: suppression of food intake by direct action in the central nervous system

1988 • 414 citations

Multiple biological activities of human recombinant interleukin 1.

1986 • 372 citations

Endotoxin, tumor necrosis factor-α and interleukin 1 induce interleukin 6 production in vivo

1989 • 298 citations

Interleukin 6 (IL-6) in serum and urine of renal transplant recipients.

1988 • 265 citations

Suppression of food intake during infection: is interleukin-1 involved?

1985 • 199 citations

Interleukin-6 is pyrogenic but not somnogenic

1989 • 114 citations

Roles of interleukin 1 beta and tumor necrosis factor in lipopolysaccharide fever in rats

1990 • 113 citations

Pyrogenic and thermogenic effects of interleukin 1 beta in the rat

1989 • 111 citations

Comparison of in vivo effects of human recombinant IL 1 and human recombinant IL 6 in mice.

1988 • 95 citations

The effects of continuous administration of murine interleukin-1α in the rat

1988 • 85 citations

Prostaglandin formation in the hypothalamus in vivo: effect of pyrogens

1989 • 83 citations

Central activation of thermogenesis and fever by interleukin-1β and interleukin-1α involves different mechanisms

1989 • 74 citations

Effect of antipyretic drugs on circadian rhythm in body temperature of rats

1987 • 67 citations

Characteristics of fever and acute-phase response induced in rabbits by IL-1 and TNF

1989 • 60 citations

Further evidence implicating prostaglandin E2 in the genesis of pyrogen fever

1988 • 59 citations

Stimulation of fibroblast proliferation and prostaglandin production by purified recombinant murine interleukin 1

1986 • 50 citations

The Biological Activity in Vivo of Recombinant Murine Interleukin 1 in the Rat

1986 • 36 citations

Hybridoma Growth Factor

1989 • 33 citations

Effect of indomethacin on febrile response to recombinant human interleukin 1-alpha in rabbits

1988 • 31 citations

Thermoregulation: Research and clinical applications

1989 • 27 citations

Prostaglandin E2 in the pathogenesis of pyrogen fever: validation of an intermediary role.

1989 • 13 citations

Central actions of interleukin-1β on fever and thermogenesis

1989 • 7 citations