GABA Release in Vivo and in Vitro: Responses to Physiological and Chemical Stimuli

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

The isolation of nerve endings from brain: an electron-microscopic study of cell fragments derived by homogenization and centrifugation.

1962 • 2,522 citations

Opiate receptor binding in primate spinal cord: distribution and changes after dorsal root section

1976 • 642 citations

THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA-PIG ILEUM

1957 • 636 citations

THE ACTION OF MORPHINE AND RELATED SUBSTANCES ON CONTRACTION AND ON ACETYLCHOLINE OUTPUT OF COAXIALLY STIMULATED GUINEA‐PIG ILEUM

1997 • 632 citations

Multiple opiate receptor sites on primary afferent fibres

1980 • 621 citations

Enkephalin inhibits release of substance P from sensory neurons in culture and decreases action potential duration.

1979 • 546 citations

γ‐VINYL GABA (4‐amino‐hex‐5‐enoic acid), A NEW SELECTIVE IRREVERSIBLE INHIBITOR OF GABA‐T: EFFECTS ON BRAIN GABA METABOLISM IN MICE¹

1977 • 472 citations

Neurotransmitters decrease the calcium component of sensory neurone action potentials

1978 • 409 citations

Multiple opiate receptors: different regional distribution in the brain and differential binding of opiates and opioid peptides.

1979 • 399 citations

4‐Amino‐hex‐5‐enoic Acid, a Selective Catalytic Inhibitor of 4‐Aminobutyric‐Acid Aminotransferase in Mammalian Brain

1977 • 375 citations

Morphine and Enkephalin: Analgesic and Epileptic Properties

1977 • 358 citations

The mechanism of inhibition of neuronal activity by opiates in the spinal cord of cat

1976 • 321 citations

Narcotic Drugs—Biochemical Pharmacology

1972 • 310 citations

Neuronal actions of endorphins and enkephalins among brain regions: a comparative microiontophoretic study.

1977 • 299 citations

Morphine- and opioid peptide-induced inhibition of the release of dopamine from tuberoinfundibular neurons

1979 • 234 citations

Opiate receptors influence vasopressin release from nerve terminals in rat neurohypophysis

1980 • 218 citations

THE EFFECT OF 4‐AMINO HEX‐5‐YNOIC ACID (γ‐ACETYLENIC GABA, γ‐ETHYNYL GABA) A CATALYTIC INHIBITOR OF GABA TRANSAMINASE, ON BRAIN GABA METABOLISM IN VIVO

1977 • 216 citations

Epileptic properties of leucine- and methionine-enkephalin: Comparison with morphine and reversibility by naloxone

1978 • 208 citations

Effects of opiates and methionine-enkephalin on pontine and bulbar respiratory neurones of the cat

1978 • 207 citations

INHIBITION BY MORPHINE OF THE RELEASE OF ACETYLCHOLINE FROM THE INTESTINE OF THE GUINEA‐PIG

1957 • 206 citations

The release of γ‐aminobutyric acid during inhibition in the cat visual cortex

1971 • 201 citations

SUPPRESSION OF TRANSMISSION OF NOCICEPTIVE IMPULSES BY MORPHINE: SELECTIVE EFFECTS OF MORPHINE ADMINISTERED IN THE REGION OF THE SUBSTANTIA GELATINOSA

1977 • 195 citations

Rate of release of amino acids from the cerebral cortex in the cat as affected by brainstem and thalamic stimulation

1969 • 194 citations

Different Brain Areas Mediate the Analgesic and Epileptic Properties of Enkephalin

1978 • 158 citations

Effects of Morphine and Naloxone on Dorsal Horn Neurones in the Cat

1974 • 143 citations

METABOLISM OF GLUCOSE AND GLUTAMATE BY SYNAPTOSOMES FROM MAMMALIAN CEREBRAL CORTEX

1969 • 142 citations

DEPOLARIZING STIMULI AND THE RELEASE OF PHYSIOLOGICALLY ACTIVE AMINO ACIDS FROM SUSPENSIONS OF MAMMALIAN SYNAPTOSOMES

1973 • 141 citations

Catalytic inhibition of γ-aminobutyric acid-α-ketoglutarate transaminase of bacterial origin by 4-aminohex-5-ynoic acid, a substrate analog

1975 • 136 citations

THE MECHANISM OF ACTION OF NARCOTIC ANALGESICS IN THE GUINEA‐PIG ILEUM

1977 • 130 citations

Actions of Tremorgenic Fungal Toxins on Neurotransmitter Release

1980 • 128 citations

The release of endogenous amino acids from the rat visual cortex.

1976 • 116 citations

Enzyme-activated irreversible inhibitors of L-ornithine:2-oxoacid aminotransferase. Demonstration of mechanistic features of the inhibition of ornithine aminotransferase by 4-aminohex-5-ynoic acid and gabaculine and correlation with in vivo activity.

1978 • 97 citations

Enkephalin-induced inhibition of cortical neurones and the lack of this effect in morphine tolerant/dependent rats

1976 • 97 citations

γ‐VINYL GABA: EFFECTS OF CHRONIC ADMINISTRATION ON THE METABOLISM OF GABA AND OTHER AMINO COMPOUNDS IN RAT BRAIN

1979 • 95 citations

Effects of Morphine and its Antagonists on Release of Cerebral Cortical Acetylcholine

1970 • 92 citations

Regiospecific 1,4 addition of a propargylic anion. A general synthon for 2-substituted propargylamines as potential catalytic irreversible enzyme inhibitors.

1975 • 73 citations

Release of amino acids from the maturing cobalt-induced epileptic focus

1976 • 69 citations

Morphine Blockade of Amino Acid Putative Transmitters on Cat Spinal Cord Sensory Interneurones

1973 • 66 citations

The Effects of Scorpion Venom Toxin on the Release of Amino Acid Neurotransmitters from Cerebral Cortex In Vivo and In Vitro

1980 • 55 citations

MODIFICATION OF BRAIN ACETYLCHOLINE RELEASE BY MORPHINE AND ITS ANTAGONISTS IN NORMAL AND MORPHINE‐DEPENDENT RATS

1974 • 54 citations

Influence of Atropine and Morphine on the Liberation of Acetylcholine from the Guinea Pig's Intestine

1956 • 53 citations

Effects of morphine, nalorphine and naloxone on neocortical release of acetylcholine in the rat

1973 • 49 citations

An electrophysiological analysis of the convulsant action of morphine, codeine and thebaine.

1961 • 48 citations

Effects of opiate-like peptides, morphine, and naloxone in the photosensitive baboon, papio papio

1979 • 48 citations

Single neuron studies of opiate action in the guinea pig myenteric plexus

1975 • 40 citations

Neurochemical bases for narcotic tolerance and dependence

1975 • 40 citations

Hyperpolarisation and depression of slow synaptic inhibition by enkephalin in frog sympathetic ganglion

1979 • 36 citations

The action of γ-vinyl-GABA and γ-acetylenic-GABA on the resting and stimulated release of GABA in vivo

1980 • 35 citations

How Gymnodinium breve red tide toxin(s) produces repetitive firing in squid axons

1977 • 35 citations

Inhibition of behavioural and EEG activation induced by morphine acting on lower brain-stem structures

1972 • 32 citations

Release of amino acids from the chronically‐superfused mammalian cerebral cortex

1974 • 30 citations

Inorganic Ions: The Role of Calcium

1971 • 28 citations

Effects of γ-acetylenic GABA and γ-vinyl GABA on synaptosomal release and uptake of GABA

1981 • 24 citations

Acetylcholine and Cholinesterase

1971 • 23 citations

Peripheral sensory stimulation and the release of transmitter amino acids in vivo from specific regions of cerebral cortex

1979 • 23 citations

STUDIES ON THE TRANSPORT OF GLUTAMINE IN VIVO BETWEEN THE BRAIN AND BLOOD IN THE RESTING STATE AND DURING AFFERENT ELECTRICAL STIMULATION

1978 • 22 citations

Suppression of evoked and spontaneous release of neurotransmitters in vivo by morphine

1980 • 17 citations

Effects of β-Bungarotoxin and Tityustoxin on Uptake and Release of Neurotransmitters

1978 • 14 citations

A method for the continuous, long term superfusion of the cerebral cortex of unanaesthetized, unrestrained rats

1974 • 11 citations

In vivo release of acetylcholine evoked by brachial plexus stimulation and tityustoxin

1980 • 8 citations