Molecular analysis of human complement component C5: localization of the structural gene to chromosome 9

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Buffer gradient gels and 35S label as an aid to rapid DNA sequence determination.

1983 • 2,456 citations

The isolation of structural genes from libraries of eucaryotic DNA

1978 • 1,877 citations

A cDNA cloning vector that permits expression of cDNA inserts in mammalian cells.

1983 • 933 citations

An interactive graphics program for comparing and aligning nucleic acid and amino acid sequences

1982 • 801 citations

Automation of the computer handling of gel reading data produced by the shotgun method of DNA sequencing

1982 • 744 citations

The structure of cytochromec and the rates of molecular evolution

1971 • 540 citations

THE DERIVATION OF TWO DISTINCT ANAPHYLATOXIN ACTIVITIES FROM THE THIRD AND FIFTH COMPONENTS OF HUMAN COMPLEMENT

1968 • 460 citations

Large scale isolation of functionally active components of the human complement system.

1981 • 446 citations

A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B

1984 • 433 citations

The structural basis of the multiple forms of human complement component C4

1984 • 419 citations

Human complement component C3: cDNA coding sequence and derived primary structure.

1985 • 410 citations

Evidence for presence of an internal thiolester bond in third component of human complement.

1980 • 368 citations

A thiol‐ester in α₂‐macroglobulin cleaved during proteinase complex formation

1980 • 330 citations

Nucleotide sequence and the encoded amino acids of human serum albumin mRNA.

1982 • 316 citations

Chromosomal localization of human cellular homologues of two viral oncogenes

1982 • 304 citations

Release of histamine from rat mast cells by the complement peptides C3a and C5a.

1975 • 290 citations

A Familial Deficiency of the Phagocytosis-Enhancing Activity of Serum Related to a Dysfunction of the Fifth Component of Complement (C5)

1970 • 259 citations

Primary structural analysis of the polypeptide portion of human C5a anaphylatoxin. Polypeptide sequence determination and assignment of the oligosaccharide attachment site in C5a.

1978 • 253 citations

Primary structure of human alpha 2-macroglobulin. V. The complete structure.

1984 • 253 citations

DISTRIBUTION, INHERITANCE, AND PROPERTIES OF AN ANTIGEN, MUB1, AND ITS RELATION TO HEMOLYTIC COMPLEMENT

1964 • 233 citations

Assignment of the structural gene for the third component of human complement to chromosome 19.

1982 • 229 citations

Generation of C5-Derived Lysosomal Enzyme-Releasing Activity (C5a) by Lysates of Leukocyte Lysosomes

1974 • 197 citations

Common evolutionary origin of alpha 2-macroglobulin and complement components C3 and C4.

1985 • 186 citations

A New Method for Purifying Lambda DNA From Phage Lysates

1985 • 178 citations

The membrane attack complex

1984 • 145 citations

Third component of human complement: structural requirements for its function

1980 • 138 citations

Third component of human complement: appearance of a sulfhydryl group following chemical or enzymic inactivation

1980 • 137 citations

Polymorphism of human complement component C4

1985 • 136 citations

Evidence for two distinct c-src loci on human chromosomes 1 and 20

1984 • 134 citations

The activation of human complement component C5 by a fluid phase C5 convertase.

1983 • 127 citations

Amino acid sequence around the thiol and reactive acyl groups of human complement component C4

1981 • 114 citations

Fifth component of human complement: purification from plasma and polypeptide chain structure

1979 • 110 citations

Nucleotide sequence of cDNA encoding human alpha 2-macroglobulin and assignment of the chromosomal locus.

1985 • 109 citations

Human C3 and C5: Subunit Structure and Modifications by Trypsin and C4̄2̄-C4̄2̄3̄

1975 • 107 citations

The gene encoding decay-accelerating factor (DAF) is located in the complement-regulatory locus on the long arm of chromosome 1.

1987 • 100 citations

Sequence determination of the thiolester site of the fourth component of human complement.

1981 • 89 citations

Structural analysis of human complement protein H: homology with C4b binding protein, beta 2-glycoprotein I, and the Ba fragment of B2.

1986 • 85 citations

Genetic defect in secretion of complement C5 in mice

1979 • 82 citations

Expression of C5a-like biological activities by the fifth component of human complement (C5) upon limited digestion with noncomplement enzymes without release of polypeptide fragments.

1983 • 82 citations

Chemotactic factor inactivators of human granulocytes.

1977 • 80 citations

Biosynthesis and Post-Synthetic Modification of a Precursor (PRO-C5) of the Fifth Component of Mouse Complement (C5)

1979 • 79 citations

Structure of murine complement component C3. II. Nucleotide sequence of cloned complementary DNA coding for the alpha chain.

1984 • 79 citations

Hereditary deficiency of the fifth component of complement in man. II. Biological properties of C5-deficient human serum.

1976 • 73 citations

Isolation and sequence analysis of a cDNA clone encoding the fifth complement component.

1985 • 66 citations

Structure of murine complement component C3. I. Nucleotide sequence of cloned complementary and genomic DNA coding for the beta chain.

1984 • 66 citations

Primary structure of the fifth component of murine complement

1987 • 65 citations

[5] High-performance liquid chromatography of amino acid derivatives

1977 • 64 citations

Chromosomal location of the genes encoding complement components C5 and factor H in the mouse.

1986 • 55 citations

Complement-independent activation of the fifth component (C5) of human complement: limited trypsin digestion resulting in the expression of biological activity.

1982 • 54 citations

The rate of molecular evolution of alpha-fetoprotein approaches that of pseudogenes.

1985 • 50 citations

Complete cDNA sequence of the fourth component of murine complement.

1985 • 47 citations

Complete nucleotide and derived amino acid sequences of the fourth component of mouse complement (C4). Evolutionary aspects.

1985 • 46 citations

A gene (Bevi) on human chromosome 6 is an integration site for baboon type C DNA provirus in human cells

1978 • 45 citations

The fifth component of complement (C5) in the mouse. Analysis of the molecular basis for deficiency.

1987 • 41 citations

A Functional Abnormality of the Fifth Component of Complement (C5) from Human Serum of Individuals with a Familial Opsonic Defect

1974 • 34 citations

Primary structure of human alpha 2-macroglobulin. I. Isolation of the 26 CNBr fragments, amino acid sequence of 13 small CNBr fragments, amino acid sequence of methionine-containing peptides, and alignment of all CNBr fragments.

1984 • 34 citations

Immunoadsorbent affinity purification of the fifth component (C5) of human complement and development of a highly sensitive hemolytic assay

1980 • 24 citations

Effect of Autologous Protein on the Specificity of the Antibody Response: Mouse and Rabbit Antibody to MuB1

1964 • 12 citations