Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on catecholamines and metabolites in primate brain and CSF

PROTEIN MEASUREMENT WITH THE FOLIN PHENOL REAGENT

1951 • 319,299 citations

Chronic Parkinsonism in Humans Due to a Product of Meperidine-Analog Synthesis

1983 • 4,822 citations

Brain dopamine and the syndromes of Parkinson and Huntington Clinical, morphological and neurochemical correlations

1973 • 2,615 citations

A primate model of parkinsonism: selective destruction of dopaminergic neurons in the pars compacta of the substantia nigra by N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine.

1983 • 2,149 citations

The projections of the ventral tegmental area and adjacent regions: A combined fluorescent retrograde tracer and immunofluorescence study in the rat

1982 • 1,693 citations

Dopamine (3-hydroxytyramine) and brain function.

1966 • 1,401 citations

Chronic parkinsonism secondary to intravenous injection of meperidine analogues

1979 • 1,356 citations

Selective nigral toxicity after systemic administration of 1-methyl-4-phenyl-1,2,5,6-tetrahydropyrine (MPTP) in the squirrel monkey

1984 • 913 citations

Reduction of cortical dopamine, noradrenaline, serotonin and their metabolites in Parkinson's disease

1983 • 712 citations

Is the mesocortical dopaminergic system involved in Parkinson disease?

1980 • 412 citations

The Clinical Syndrome of Striatal Dopamine Deficiency

1985 • 241 citations

3,4-Dihydroxyphenylacetic acid and homovanillic acid in rat plasma: Possible indicators of central dopaminergic activity

1979 • 213 citations

Sites of the neurotoxic action of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine in the macaque monkey include the ventral tegmental area and the locus coeruleus

1985 • 155 citations

Neurochemistry of Parkinson's disease: relation between striatal and limbic dopamine.

1978 • 130 citations

Plasma and cerebrospinal fluid 3-methoxy-4-hydroxyphenylethylene glycol (MHPG) as indices of brain norepinephrine metabolism in primates

1982 • 121 citations

N-methyl-4-phenyl-1,2,3,6-tetra-hydropyridine (MPTP) causes destruction of the nigrostriatal but not the mesolimbic dopamine system in the monkey.

1984 • 75 citations

Brain-noradrenaline and 3-methoxy-4-hydroxyphenylglycol in Parkinson's syndrome

1977 • 73 citations

Preferential vulnerability of A8 dopamine neurons in the primate to the neurotoxin 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine

1986 • 72 citations

The use of C8-octyl columns for the analysis of catecholamines by ion-pair reversed-phase liquid chromatography with amperometric detection

1981 • 68 citations

Differential responsiveness to 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in sub-regions of the primate substantia nigra and striatum

1987 • 66 citations

Microtopography of methionine-enkephalin, dopamine and noradrenaline in the ventral mesencephalon of human control and Parkinsonian brains

1982 • 63 citations

Organization of mesencephalic dopamine neurons projecting to neocortex and septum.

1977 • 54 citations

Relative Importance of 3‐Methoxy‐4‐Hydroxyphenylglycol and 3,4‐Dihydroxyphenylglycol as Norepinephrine Metabolites in Rat, Monkey, and Humans

1983 • 54 citations

Origin of brain stem and temporal cortical afferent fibers to the septal region in the squirrel monkey

1981 • 14 citations