Quantitative Methods for Amino Acid Analysis in Biological Fluids

Automatic Recording Apparatus for Use in Chromatography of Amino Acids

1958 • 9,612 citations

The Metabolic Basis of Inherited Disease

1990 • 4,327 citations

CHROMATOGRAPHY OF AMINO ACIDS ON SULFONATED POLYSTYRENE RESINS

1951 • 1,746 citations

Total homocysteine in plasma or serum: methods and clinical applications

1993 • 996 citations

Synthesis of a Fluorescent Derivatizing Reagent, 6-Aminoquinolyl-N-Hydroxysuccinimidyl Carbamate, and Its Application for the Analysis of Hydrolysate Amino Acids via High-Performance Liquid Chromatography

1993 • 950 citations

THE FREE AMINO ACIDS OF HUMAN BLOOD PLASMA

1954 • 939 citations

Enzymic fluorometric continuous-flow assays for blood glucose, lactate, pyruvate, alanine, glycerol, and 3-hydroxybutyrate.

1978 • 593 citations

Determination of amino acids with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography

1983 • 553 citations

Homocysteine and other thiols in plasma and urine: automated determination and sample stability

1993 • 480 citations

Fluorimetric method for the determination of phenylalanine in serum

1962 • 466 citations

Quantitative analysis of the pyridinium crosslinks of collagen in urine using ion-paired reversed-phase high-performance liquid chromatography

1988 • 443 citations

Mass spectrometry/mass spectrometry: techniques and applications of tandem mass spectrometry

1990 • 441 citations

Handbook of derivatives for chromatography

1994 • 440 citations

Mass spectrometry/mass spectrometry. Techniques and applications of tandem mass spectrometry

1989 • 431 citations

Amino acid analysis utilizing phenylisothiocyanate derivatives

1988 • 416 citations

Dansylation of amino acids for high-performance liquid chromatography analysis

1981 • 381 citations

Rapid diagnosis of phenylketonuria by quantitative analysis for phenylalanine and tyrosine in neonatal blood spots by tandem mass spectrometry

1993 • 370 citations

Rapid assay for amino acids in serum or urine by pre-column derivatization and reversed-phase liquid chromatography.

1982 • 368 citations

High-performance capillary electrophoresis in the biological sciences

1989 • 316 citations

Milk protein quantity and quality in low-birth-weight infants

1977 • 308 citations

Practical Clinical Biochemistry

1959 • 303 citations

A simple, rapid method for the determination of glucose, lactate, pyruvate, alanine, 3-hydroxybutyrate and acetoacetate on a single 20-μl blood sample

1982 • 289 citations

Technical pitfalls leading to errors in the quantitation of plasma amino acids

1969 • 268 citations

Appraisal of four pre-column derivatization methods for the high-performance liquid chromatographic determination of free amino acids in biological materials

1990 • 258 citations

Recommendations on the dietary management of phenylketonuria. Report of Medical Research Council Working Party on Phenylketonuria.

1993 • 249 citations

Immunoassay for urinary pyridinoline: The new marker of bone resorption

1993 • 245 citations

Homocysteine and other thiols determined in plasma by HPLC and thiol-specific postcolumn derivatization

1993 • 244 citations

THE CONCENTRATIONS OF CYSTEINE AND CYSTINE IN HUMAN BLOOD PLASMA

1960 • 227 citations

Disturbances of amino acid metabolism : clinical chemistry and diagnosis

1981 • 225 citations

CAPILLARY ELECTROPHORESIS

1989 • 218 citations

Enantiomer labelling, a method for the quantitative analysis of amino acids

1978 • 212 citations

Profiling of amino acids in body fluids and tissues by means of liquid chromatography

1986 • 190 citations

A study of plasma free amino acid levels. II. Normal values for children and adults

1973 • 184 citations

Handbook of Derivatives for Chromatography

1979 • 169 citations

Amino-acids on Hands

1965 • 160 citations

An ultra rapid and sensitive high-performance liquid chromatographic method for determination of tissue and plasma free amino acids

1985 • 159 citations

Chiral separations by HPLC

1989 • 158 citations

Chiral separations by HPLC

1989 • 154 citations

Capillary gas chromatography of amino acids, including asparagine and glutamine: sensitive gas chromatogaphic—mass spectrometric and selected ion monitoring gas chromatographic—mass spectrometric detection of the N,O(S)-tert.-butyldimethylsilyl derivatives

1987 • 142 citations

The analysis of diagnostic markers of genetic disorders in human blood and urine using tandem mass spectrometry with liquid secondary ion mass spectrometry

1991 • 141 citations

High-performance liquid chromatography and sensitive detection of amino acids derivatized with 7-fluoro-4-nitrobenzo-2-oxa-1,3-diazole

1981 • 141 citations

Total amino acid analysis using pre-column fluorescence derivatization

1982 • 137 citations

ENDOGENOUS RENAL TRANSPORT OF FREE AMINO ACIDS IN INFANCY AND CHILDHOOD

1968 • 136 citations

Selective determination of secondary amino acids using precolumn derivatization with 9-fluorenylmethylchloroformate and reversed-phase high-performance liquid chromatography

1985 • 130 citations

Milk Protein Quantity and Quality in Low-Birth-Weight Infants: II. Effects on Selected Aliphatic Amino Acids in Plasma and Urine

1977 • 125 citations

THE FREE AMINO ACIDS OF HUMAN SPINAL FLUID DETERMINED BY ION EXCHANGE CHROMATOGRAPHY

1966 • 119 citations

Pre-column labelling for high-performance liquid chromatography of amino acids with 7-fluoro-4-nitrobenzo-2-oxa-1,3-diazole and its application to protein hydrolysates

1982 • 114 citations

Milk Protein Quantity and Quality in the Term Infant II. Effects on Acidic and Neutral Amino Acids

1982 • 109 citations

Free and conjugated amino acids in human CSF: Influence of age and sex

1985 • 108 citations

The free amino acids in human cerebrospinal fluid

1972 • 107 citations

Indices of Protein Metabolism in Term Infants Fed Human Milk, Whey-Predominant Formula, or Cow's Milk Formula

1985 • 103 citations

Fully automated liquid-chromatographic determination of amino acids.

1988 • 103 citations

Heritable Disorders of Amino Acid Metabolism: Patterns of Clinical Expression and Genetic Variation.

1975 • 102 citations

High-performance liquid chromatographic analysis of amino acids in physiological fluids: On-line precolumn derivatization with o-phthaldialdehyde

1983 • 100 citations

Chiral Liquid Chromatography

1989 • 98 citations

Bone-Resorption Markers Galactosyl Hydroxylysine, Pyridinium Crosslinks, and Hydroxyproline Compared

1992 • 96 citations

Determination of cysteine in plasma and urine and homocysteine in plasma by high-pressure liquid chromatography

1978 • 96 citations

On the determination of free amino acids in serum

1965 • 93 citations

The stability of the o-phthalaldehyde/2-mercaptoethanol derivatives of amino acids: An investigation using high-pressure liquid chromatography with a precolumn derivatization technique

1984 • 93 citations

A method for measurement of free and bound plasma cyst(e)ine

1981 • 93 citations

A study of plasma free amino acid levels. I. Study of factors affecting validity of amino acid analyses

1973 • 92 citations

Amino acid analysis of physiological fluids by high-performance liquid chromatography with phenylisothiocyanate derivatization and comparison with ion-exchange chromatography

1990 • 75 citations

Gas—liquid chromatography of isobutyl ester, N(O)-heptafluorobutyrate derivatives of amino acids on a glass capillary column for quantitative separation in clinical biology

1979 • 69 citations

Sensitive detection of amino acids in human serum and dried blood disc of 3 mm diameter for diagnosis of inborn errors of metabolism

1984 • 67 citations

Amino acid abnormalities in cerebrospinal fluid of patients with parkinsonism and extrapyramidal disorders

1976 • 65 citations

The Normal Venous Plasma Free Amino Acid Levels of Non‐Pregnant Women and of Mother and Child during Delivery

1967 • 62 citations

ANTENATAL DIAGNOSIS AND AMINOACID COMPOSITION OF AMNIOTIC FLUID

1970 • 59 citations

PLASMA AMINO ACIDS AFTER BIRTH

1964 • 58 citations

Amino acid analysis by gas chromatography

1987 • 54 citations

Direct analysis of peptides and amino acids from capillary electrophoresis

1991 • 52 citations

2nd international symposium on high performance capillary electrophoresis

1990 • 52 citations

Measurement of plasma and urine amino acids by high-performance liquid chromatography with electrochemical detection using phenylisothiocyanate derivatization

1990 • 51 citations

Determination of free amino acids in biological samples: Problems of quantitation

1989 • 51 citations

Monitoring of phenylketonuria: A colorimetric method for the determination of plasma phenylalanine using l-phenylalanine dehydrogenase

1989 • 49 citations

Determination of delta-aminobutyric acid and other amino acids in cerebrospinal fluid of pediatric patients by reversed-phase liquid chromatography.

1987 • 48 citations

Plasma amino-acids analysis: Effects of delayed samples preparation and of storage

1987 • 47 citations

Quantitative amino acids in amniotic fluid and maternal plasma in early and late pregnancy

1971 • 46 citations

Amino Acid Concentrations in Cerebrospinal Fluid

1978 • 45 citations

Age-related reference values for free amino acids in first morning urine specimens.

1988 • 45 citations

Diet-related reference values for plasma amino acids in newborns measured by reversed-phase HPLC

1990 • 44 citations

General problems associated with the analysis of amino acids by automated ion-exchange chromatography

1986 • 43 citations

HPLC measurement of phenylalanine in plasma.

1988 • 43 citations

Determination of enantiomer-labeled amino acids in small volumes of blood by gas chromatography

1982 • 41 citations

A rapid and sensitive procedure for the quantitative determination of plasma amino acids

1982 • 41 citations

Automatic amino acid analysis utilizing 4-fluoro-7-nitrobenzo-2-oxa-1,3-diazole

1987 • 41 citations

Plasma amino acid concentrations in newborn infants breast-fed ad libitum

1978 • 39 citations

Reference values for amino acids in cerebrospinal fluid of children determined using ion-exchange chromatography with fluorimetric detection

1989 • 39 citations

Prenatal Diagnosis of Nonketotic Hyperglycinemia

1982 • 38 citations

The Effects of Human Milk and Low-Protein Formulae on the Rates of Total Body Protein Turnover and Urinary 3-Methyl-Histidine Excretion of Preterm Infants

1983 • 38 citations

PLASMA FREE AMINO ACID CONCENTRATIONS OF BREAST‐FED INFANTS

1978 • 38 citations

Plasma Amino Acid Differences in Very Low Birth Weight Infants Fed either Human Milk or Whey-Dominant Cow Milk Formula

1987 • 37 citations

Phenylalanine and tyrosine in serum and eluates from dried blood spots as determined by reversed-phase liquid chromatography.

1987 • 36 citations

Capillary gas chromatography micro-assay for pyroglutamic, glutamic and aspartic acids, and glutamine and asparagine

1986 • 34 citations

Amino Acids, Including Asparagine and Glutamine, in Plasma and Urine of Normal Human Subjects

1969 • 33 citations

Separation of cystine, penicillamine disulfide and cysteine-penicillamine mixed disulfide by automatic amino acid analysis

1966 • 32 citations

High-speed liquid chromatographic analysis of amino acids by post-column sodium hypochlorite-o∼phthalaldehyde reaction

1985 • 32 citations

Plasma amino acid concentrations in umbilical cord vein and artery of newborn infants after elective cesarean section or spontaneous delivery

1978 • 31 citations

HPLC assay of phenylalanine and tyrosine in blood spots on filter paper

1986 • 30 citations

Amino acid analysis of plasma: studies in sample preparation

1988 • 28 citations

Stability of amino acids in human plasma

1985 • 28 citations

Growth Velocity and Plasma Amino Acids in the Newborn

1985 • 27 citations

Amino Acids in Amniotic Fluid: Changes in Concentrations During the First Half of Pregnancy

1972 • 26 citations

Difficulties and pitfalls in the interpretation of screening tests for the detection of inborn errors of metabolism

1976 • 26 citations

Automatic analysis of amino acids: Effect of resin cross-linking and operational variables on resolution

1969 • 24 citations

Amino acid concentrations in serum and aqueous humor from subjects with extreme myopia or senile cataract.

1988 • 23 citations

Inborn Metabolic Diseases

1990 • 23 citations

Differential diagnosis of (inherited) amino acid metabolism or transport disorders

1992 • 23 citations

Glycinelserine ratios in amniotic fluid: an unreliable indicator for the prenatal diagnosis of nonketotic hyperglycinemia

1983 • 22 citations

Identification of phenylthiocarbamyl amino acids for compositional analysis by thermospray liquid chromatography/mass spectrometry

1989 • 22 citations

A high-resolution method for amino acid analysis of physiological fluids containing mixed disulfides.

1988 • 21 citations

Enzymatic phenylalanine estimation for the management of patients with phenylketonuria

1991 • 21 citations

Gas chromatography method for the separation of amino acids enantiomers in plasma and urine. Application in a case of short bowel syndrome

1991 • 21 citations

Prenatal diagnosis of non‐ketotic hyperglycinemia

1986 • 20 citations

Recent Developments in Amino Acid Analysis by Gas‐Liquid Chromatography

1981 • 20 citations

A Clinical Biochemist’s View of the Investigation of Suspected Inherited Metabolic Disease

1989 • 20 citations

Gas chromatography—biochemical, biomedical and clinical applications

1991 • 20 citations

Further Characterization of In Vitro Conditions Appropriate for GABA Determination in Human CSF: Impact of Acid Deproteinization and Freeze/Thaw

1983 • 19 citations

Neonatal Screening for Phenylketonuria: Evaluation of an Automated Enzymatic Method

1994 • 19 citations

Liquid-chromatographic measurement of amino acids in biological samples after formation of phenylthiohydantoin derivatives.

1984 • 19 citations

Single-column amino acid analysis with o-phthalaldehyde: An evaluation of two commercial buffer systems

1982 • 19 citations

Development and validation of a robust specific enzyme mediated assay for phenylalanine in serum

1992 • 18 citations

Liquid-chromatographic measurement of amino acids in biological samples after formation of phenylthiohydantoin derivatives.

1984 • 18 citations

Effect of Low, Normal and High Dietary Protein Intake on Urinary Amino Acid Excretion and Plasma Aminogram in Children

1974 • 18 citations

Selective and sensitive determination of urinary total proline and hydroxyproline by gas chromatography with flame photometric detection

1993 • 18 citations

Optimized methods to measure acetoacetate, 3‐hydroxybutyrate, glycerol, alanine, pyruvate, lactate and glucose in human blood using a centrifugal analyser with a fluorimetric attachment

1990 • 17 citations

Paediatric Chemical Pathology

1996 • 17 citations

EDTA in vacutainer tubes can interfere with plasma amino acid analysis.

1983 • 16 citations

Concentrations of the free amino acids in human amniotic fluid during normal and abnormal pregnancies

1974 • 16 citations

Determination of amino acids by means of glass capillary gas-liquid chromatography with temperature-programmed electron-capture detection

1982 • 15 citations

Free amino acid analysis of untimed and 24-h urine samples compared.

1980 • 15 citations

Effect of sampling site on plasma amino acid concentrations of infants: effect of skin amino acids

1982 • 15 citations

A collaborative study on the determination of free amino acids in blood plasma

1980 • 15 citations

Comparative column chromatographic estimations of phenylalanine in plasma, whole blood, native and paper‐dried capillary blood of healthy children and adults, and patients with hyperphenylalaninaemia

1984 • 14 citations

Preliminary report on inverse diurnal variation of phenylalanine: implications in maternal phenylketonuria.

1985 • 14 citations

Prenatal diagnosis of Non‐ketotic hyperglycinaemia

1991 • 14 citations

The Inherited Metabolic Diseases

1995 • 14 citations

Amino acid profiles by HPLC after filter paper sampling: ‘Appropriate technology’ for monitoring of nutritional status

1990 • 13 citations

Coulometric Electrochemical Detection of Hydroxyproline Using 7-Chloro-4-nitrobenzo-2-oxa-1,3-diazole

1993 • 12 citations

Intra- and interlaboratory quality control for assay of amino acids in biological fluids: 14 years of the French experience

1993 • 12 citations

Establishment of an External Quality-Assessment Scheme for Amino Acid Analyses: Results from Assays of Samples Distributed during Two Years

1992 • 11 citations

A Practical Approach to the Investigation of Amino Acid Disorders

1988 • 11 citations

Phenylalanine: Application of a Simple HPLC Technique to its Measurement in Dried Blood Spots

1992 • 10 citations

Establishment of an external quality-assessment scheme for amino acid analyses: results from assays of samples distributed during two years

1990 • 10 citations

Bestimmung von freien aminosäuren im augenkammerwasser des menschen bei homocystinurie-patienten und kontrollfällen

1968 • 10 citations

Amino acid excretion of premature infants receiving different amounts of protein

1973 • 10 citations

REMARKS ON THE AQUEOUS HUMOR/PLASMA RATIOS FOR AMINO ACIDS AND RELATED COMPOUNDS IN PATIENTS WITH VARIOUS CHRONIC OCULAR DISORDERS

1975 • 9 citations

Geschlechtsspezifische Unterschiede der freien Aminosäuren im Urin von Erwachsenen

1973 • 9 citations

Why the Assay of Serum Cystine by Protein Precipitation and Chromatography Should Be Abandoned

1988 • 9 citations

Genetic Biochemical Disorders

1986 • 9 citations

Phenylalanine determined in plasma with use of phenylalanine dehydrogenase and a centrifugal analyzer

1993 • 9 citations

Development of an Enzyme-Mediated Assay for Phenylalanine in Blood Spots

1994 • 8 citations

Preparation of plasma samples for amino acid analysis by equilibrium dialysis

1978 • 8 citations

Rapid automated enzymatic measurement of phenylalanine in plasma and blood spots

1993 • 8 citations

Plasma Amino Acid Patterns in Critically Ill Children

1986 • 8 citations

Phenylalanine determined in plasma with use of phenylalanine dehydrogenase and a centrifugal analyzer.

1993 • 8 citations

A clinical biochemist's view of the investigation of suspected inherited metabolic disease

1989 • 7 citations

Liquid-chromatographic measurement of phenylalanine and tyrosine in serum.

1982 • 7 citations

Liquid chromatographic analysis of amino acids in physiological fluids: recent advances.

1991 • 7 citations

A new pitfall in plasma amino acid analysis.

1989 • 7 citations

4 Fetal diagnosis of inborn errors of metabolism

1987 • 7 citations

Vigabatrin — interference with urinary amino acid analysis

1993 • 6 citations

Plasma amino acid patterns in critically ill children

1986 • 6 citations

An alternative way of presenting quantitative amino acid results

1987 • 6 citations

Fecal Contamination in Urine Amino Acid Screening: Artifactual Cause of Hyperaminoaciduria

1969 • 5 citations

Prenatal Diagnosis of Non-Ketotic Hyperglycinaemia: Amniotic Fluid Glycine and Glycine: Serine Ratios

1987 • 4 citations

A Gas-Liquid Chromatographic Analysis of Sulfur-Containing Amino Acids Employing Flame Photometric Detection

1980 • 4 citations

Ampicillin and amino acid analysis

1975 • 4 citations

Amino acid analysis by gas—liquid chromatography using a nitrogen-selective detector

1986 • 4 citations

Nonketotic Hyperglycinemia

1990 • 4 citations

A review of quantitative ion exchange, high performance liquid and gas chromatographic analysis of amino acids in physiological fluids

1989 • 4 citations

A comparison of internal and external standardization in amino acid analysis

1985 • 2 citations

Amino acids

1991 • 2 citations

Amino acids

1992 • 2 citations

Therapeutic agents affecting amino acid chromatograms.

1989 • 2 citations

Amino acids

1993 • 2 citations