Drug disposition and drug hypersensitivity

Carcinogenesis by chemicals: an overview--G. H. A. Clowes memorial lecture.

1970 • 1,464 citations

The Pharmacological Basis of Therapeutics

1976 • 894 citations

STUDIES ON THE SENSITIZATION OF ANIMALS WITH SIMPLE CHEMICAL COMPOUNDS

1935 • 697 citations

IMMUNE-COMPLEX GLOMERULOPATHY IN PATIENTS TREATED WITH CAPTOPRIL

1980 • 305 citations

Antibodies to the Surface of Halothane-Altered Rabbit Hepatocytes in Patients with Severe Halothane-Associated Hepatitis

1980 • 285 citations

Biochemical Mechanisms in Chemical-Induced Lung Injury: Roles of Metabolic Activation

1980 • 246 citations

Activation of pharmacologic agents to radical intermediates

1982 • 190 citations

ELICITATION OF DELAYED ALLERGIC SKIN REACTIONS WITH HAPTENS: THE DEPENDENCE OF ELICITATION ON HAPTEN COMBINATION WITH PROTEIN

1952 • 188 citations

ANGIOTENSIN-CONVERTING ENZYME INHIBITORS: PAST, PRESENT, AND BRIGHT FUTURE

1985 • 186 citations

IMMUNOREACTIONS INVOLVING PLATELETS

1958 • 165 citations

Circulating Antibody Directed against Penicillin

1958 • 143 citations

Halothane anaesthesia and liver damage.

1984 • 139 citations

THE PREPARATION AND SOME PROPERTIES OF PENICILLENIC ACID DERIVATIVES RELEVANT TO PENICILLIN HYPERSENSITIVITY

1962 • 130 citations

Tolyl-specific IgE antibodies in workers with hypersensitivity to toluene diisocyanate

1978 • 122 citations

The Role of Metabolite-Specific Antibodies in Nomifensine-Dependent Immune Hemolytic Anemia

1985 • 112 citations

Fab-mediated binding of drug-dependent antibodies to platelets in quinidine- and quinine-induced thrombocytopenia.

1985 • 110 citations

IMMUNOCHEMICAL STUDY OF ANTIGENIC SPECIFICITY IN DELAYED HYPERSENSITIVITY

1966 • 108 citations

Immunogenicity of a Series of α,N-DNP-L-Lysines^*

1965 • 103 citations

Products of aminolysis and enzymic hydrolysis of the cephalosporins

1970 • 94 citations

In vitro evaluation of a toxic metabolite of sulfadiazine

1985 • 90 citations

DETECTION OF IgE ANTIBODIES TO SUXAMETHONIUM AFTER ANAPHYLACTOID REACTIONS DURING ANAESTHESIA

1984 • 88 citations

Antigenicity and Cross-Reactivity of Penicillins and Cephalosporins

1973 • 87 citations

Further studies of the human platelet receptor for quinine- and quinine-dependent antibodies.

1981 • 86 citations

Detection of Serum IgE Antibodies that React with Alcuronium and Tubocurarine after Lifethreatening Reactions to Muscle-relaxant Drugs

1983 • 77 citations

The biliary and urinary metabolites of [3H]17α-ethynylestradiol in women

1983 • 74 citations

ANAPHYLACTOID REACTIONS IN DIALYSIS PATIENTS: ROLE OF ETHYLENE-OXIDE

1985 • 71 citations

ASSOCIATION OF ETHYLENE-OXIDE-INDUCED IgE ANTIBODIES WITH SYMPTOMS IN DIALYSIS PATIENTS

1985 • 64 citations

Human Antibodies against Formaldehyde-Human Serum Albumin Conjugates or Human Serum Albumin in Individuals Exposed to Formaldehyde

1986 • 61 citations

Anatagonism of the cytocidal activity and uptake of melphalan by tamoxifen in human breast cancer cells in vitro

1985 • 59 citations

Drug protein conjugates—I. A study of the covalent binding of [14C]captopril to plasma proteins in the rat

1982 • 58 citations

An enzyme-linked immunosorbent assay for detection of antibodies against halothane-altered hepatocyte antigens

1984 • 54 citations

Metabolism of procainamide to a hydroxylamine by rat and human hepatic microsomes.

1984 • 54 citations

-Globulin binding of morphine in heroin addicts.

1972 • 52 citations

Studies on 5,5-diphenylhydantoin irreversible binding to rat liver microsomal proteins

1982 • 49 citations

Specific Inhibition of Allergic Reactions to Penicillin in Man by a Monovalent Hapten

1972 • 48 citations

Possible role of antibody specific for a practolol metabolite in the pathogenesis of oculomucocutaneous syndrome.

1978 • 47 citations

Cutaneous reactions to captopril

1984 • 46 citations

Contact Sensitivity in the Pig

1978 • 45 citations

Morphine metabolism revisited. II. Isolation and chemical characterization of a glutathionylmorphine adduct from rat liver microsomal preparations

1984 • 41 citations

Immune Mechanisms for Induction of Penicillin Allergy

2015 • 39 citations

Antibodies to DNA and a Synthetic Polydeoxyribonucleotide Produced by Oligodeoxyribonucleotides

1965 • 39 citations

Prospective study of immunologic effects of hydralazine in hypertensive patients

1981 • 37 citations

Assay of protein-quinone coupling involving compounds structurally related to the active principle of poison ivy

1968 • 37 citations

Studies on the mechanism of covalent binding of morphine metabolites to proteins in mouse.

1983 • 36 citations

Drug-protein conjugates—IX

1985 • 36 citations

Immunochemical studies on delayed and arthus-type hypersensitivity reactions. I. The relationship between antigenic determinant size and antibody combining site size.

1967 • 36 citations

New Aspects on Antigens in Penicillin Allergyss

1980 • 32 citations

Drug‐specific antibodies in patients receiving captopril.

1986 • 32 citations

Drug protein conjugates—VI. Role of glutathione in the metabolism of captopril and captopril plasma protein conjugates

1983 • 29 citations

Drug-protein conjugates—XII a study of the disposition, irreversible binding and immunogenicity of penicillin in the rat

1987 • 28 citations

Drug protein conjugates—III. Inhibition of the irreversible binding of ethinylestradiol to rat liver microsomal protein by mixed-function oxidase inhibitors, ascorbic acid and thiols

1983 • 28 citations

Thrombocytopenia and leucopenia with mianserin‐dependent antibodies.

1985 • 27 citations

Immunochemical Studies on Delayed and Arthus-Type Hypersensitivity Reactions

1967 • 24 citations

Induction of benzylpenicilloyl specific antibodies, including IgE, by long‐term administration of benzylpenicillin

1983 • 23 citations

Drug-protein conjugates—VIII The metabolic fate of the dinitrophenyl hapten conjugated to albumin

1985 • 23 citations

Hypersensitivity reaction to a metabolite of cyclophosphamide

1985 • 22 citations

Drug-protein conjugates—V

1983 • 21 citations

Enzyme-mediated covalent binding of hydralazine to rat liver microsomes.

1983 • 18 citations

Contact sensitivity in the pig. II. Induction by intralymphatic infusion of DNP conjugated cells.

1978 • 18 citations

Autoallergic reactions induced by procainamide

1984 • 14 citations

Antigens in Penicillin Allergy

1977 • 13 citations

Drug-protein conjugates—X

1986 • 12 citations

Practolol metabolism. III. Irreversible binding of [14C]practolol metabolite(s) to mammalian liver microsomes.

1981 • 11 citations

Antigens in penicillin allergy. II. The influence of the number of penicilloyl residues on the antigenicity of macromolecules as determined by radioimmunoassay (RIA), passive cutaneous anaphylaxis (PCA) and antibody induction.

1977 • 11 citations

Contact Sensitivity in the Pig

1978 • 10 citations

[Amodiaquine-induced agranulocytosis in malaria prevention: demonstration of an amodiaquine-induced cytotoxic antibody against granulocytes].

1983 • 10 citations

Contact sensitivity in the pig. III. Induction by intralymphatic infusion of DNP-conjugated cell membranes and soluble proteins, free DNFB and some small molecular weight derivatives.

1978 • 8 citations

Drug-protein conjugates-VII

1984 • 7 citations

Metabolism and nephrotoxicity of phenacetin and sulfanilamide.

1985 • 6 citations

Summary

1984 • 5 citations

The demonstration of antibodies to para-aminosalicylic acid in human serum.

1968 • 3 citations