Two monoclonal anti‐CD3 antibodies can induce different events in human T lymphocyte activation

Leukocyte Typing II

1986 • 688 citations

Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway.

1984 • 506 citations

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

1986 • 369 citations

Cross-linking of human T cell receptor proteins: association between the T cell idiotype β subunit and the T3 glycoprotein heavy subunit

1985 • 303 citations

The events of primary T cell activation can be staged by use of Sepharose-bound anti-T3 (64.1) monoclonal antibody and purified interleukin 1.

1985 • 189 citations

Tolerance of T-cell clones is associated with membrane antigen changes

1983 • 187 citations

Ligand-receptor interactions required for commitment to the activation of the interleukin 2 gene.

1987 • 182 citations

Antibody binding to CD5 (Tp67) and Tp44 T cell surface molecules: effects on cyclic nucleotides, cytoplasmic free calcium, and cAMP-mediated suppression.

1986 • 166 citations

Mechanisms by which accessory cells contribute in growth of resting T lymphocytes initiated by OKT3 antibody

1985 • 126 citations

Interleukin 2-induced lymphocyte proliferation is independent of increases in cytosolic-free calcium concentrations.

1985 • 113 citations

The T3 complex on human thymus‐derived lymphocytes contains two different subunits of 20 kDa

1983 • 99 citations

Investigation of early T cell activation: Analysis of the effect of specific antigen, interleukin 2 and monoclonal antibodies on intracellular free calcium concentration

1985 • 88 citations

Mitogens trigger a calcium-independent signal for proliferation in phorbol-ester-treated lymphocytes

1985 • 88 citations

T cell activation by anti‐T3 antibodies: Comparison of IgG₁ and IgG_2b switch variants and direct evidence for accessory function of macrophage Fc receptors

1986 • 76 citations

The mitogenic activity of OKT3 and anti-Leu 4 monoclonal antibodies: A comparative study

1983 • 76 citations

The lymphocyte cytoskeleton and its control of surface receptor functions.

1983 • 34 citations

Early events during primary activation of T cells: antigen receptor cross‐linking and interleukin 1 initiate proliferative response of human T cells

1985 • 32 citations

Molecular mechanisms involved in T cell activation. I. Evidence for independent signal-transducing pathways in lymphokine production vs proliferation in cloned cytotoxic T lymphocytes.

1987 • 29 citations