Formation of Protein Tyrosine ortho-Semiquinone Radical and Nitrotyrosine from Cytochrome c-derived Tyrosyl Radical

Hydroperoxide metabolism in mammalian organs.

1979 • 5,821 citations

Induction of Apoptotic Program in Cell-Free Extracts: Requirement for dATP and Cytochrome c

1996 • 5,133 citations

The mitochondrial generation of hydrogen peroxide. General properties and effect of hyperbaric oxygen

1973 • 2,608 citations

The cellular production of hydrogen peroxide

1972 • 1,526 citations

Mitochondrial Biogenesis in Mammals: The Role of Endogenous Nitric Oxide

2003 • 1,199 citations

Biological Tyrosine Nitration: A Pathophysiological Function of Nitric Oxide and Reactive Oxygen Species

1998 • 1,024 citations

Does nitric oxide modulate mitochondrial energy generation and apoptosis?

2002 • 779 citations

Myeloperoxidase, a Leukocyte-Derived Vascular NO Oxidase

2002 • 675 citations

Diffusion-limited Reaction of Free Nitric Oxide with Erythrocytes

1998 • 506 citations

Measurement and characterization of postischemic free radical generation in the isolated perfused heart

1989 • 383 citations

Tyrosine radicals are involved in the photosynthetic oxygen-evolving system.

1987 • 377 citations

Protein Nitration in Cardiovascular Diseases

2002 • 372 citations

Cytochrome c Nitration by Peroxynitrite

2000 • 348 citations

Inactivation of ribonucleotide reductase by nitric oxide

1991 • 331 citations

Concentration-dependent Effects of Nitric Oxide on Mitochondrial Permeability Transition and Cytochrome cRelease

2000 • 326 citations

Mitochondria, oxygen free radicals, and apoptosis

2001 • 300 citations

Cytochrome c release and caspase activation in hydrogen peroxide‐ and tributyltin‐induced apoptosis

1998 • 254 citations

Role of Cytochrome c as a Stimulator of α-Synuclein Aggregation in Lewy Body Disease

1999 • 229 citations

Reactions of nitric oxide with mitochondrial cytochrome c: a novel mechanism for the formation of nitroxyl anion and peroxynitrite

1998 • 203 citations

Reperfusion injury

1988 • 191 citations

Quenching of the tyrosyl free radical of ribonucleotide reductase by nitric oxide. Relationship to cytostasis induced in tumor cells by cytotoxic macrophages.

1994 • 187 citations

Nitric Oxide Trapping of the Tyrosyl Radical of Prostaglandin H Synthase-2 Leads to Tyrosine Iminoxyl Radical and Nitrotyrosine Formation

1997 • 166 citations

Evidence for the Role of a Peroxidase Compound I-type Intermediate in the Oxidation of Glutathione, NADH, Ascorbate, and Dichlorofluorescin by Cytochrome c/H2O2

2003 • 158 citations

Semiquinone anion radicals of catechol(amine)s, catechol estrogens, and their metal ion complexes.

1985 • 157 citations

Semiquinone anion radicals from addition of amino acids, peptides, and proteins to quinones derived from oxidation of catechols and catecholamines. An ESR spin stabilization study.

1987 • 151 citations

Mitochondria, nitric oxide, and cardiovascular dysfunction

2002 • 149 citations

Intracellular Acidification Triggered by Mitochondrial-derived Hydrogen Peroxide Is an Effector Mechanism for Drug-induced Apoptosis in Tumor Cells

2001 • 148 citations

Nature of the free radical in ribonucleotide reductase from Escherichia coli.

1977 • 148 citations

Direct Evidence for a Tyrosine Radical in the Reaction of Cytochrome c Oxidase with Hydrogen Peroxide

1999 • 146 citations

Site-specific spin trapping of tyrosine radicals in the oxidation of metmyoglobin by hydrogen peroxide

1998 • 141 citations

Regulation of Xanthine Oxidase by Nitric Oxide and Peroxynitrite

2000 • 138 citations

Tyrosine radicals in photosystem II and related model compounds. Characterization by isotopic labeling and EPR spectroscopy

1990 • 132 citations

ESR Spin-trapping of a Protein-derived Tyrosyl Radical from the Reaction of Cytochrome with Hydrogen Peroxide

1996 • 131 citations

Nitric Oxide Down-regulates MKP-3 mRNA Levels

2000 • 123 citations

Mitochondrial targets of oxidative stress during renal ischemia/reperfusion

2003 • 115 citations

Protein Oxidation of Cytochrome c by Reactive Halogen Species Enhances Its Peroxidase Activity

2002 • 109 citations

Peroxidation of a Specific Tryptophan of Metmyoglobin by Hydrogen Peroxide

1997 • 107 citations

Mitochondrial tyrosine nitration precedes chronic allograft nephropathy

2001 • 95 citations

Tyrosinase-catalyzed oxidation of dopa and related catechol(amine)s: a kinetic electron spin resonance investigation using spin-stabilization and spin label oximetry

1987 • 72 citations

A long-lived tyrosyl radical from the reaction between horse metmyoglobin and hydrogen peroxide

2000 • 67 citations

NO Interacts with the Tyrosine Radical Y_D^• of Photosystem II To Form an Iminoxyl Radical

1997 • 62 citations

An Electron Spin Resonance Spin-trapping Investigation of the Free Radicals Formed by the Reaction of Mitochondrial Cytochromec Oxidase with H2O2

1999 • 61 citations

Characterization of Cytochrome c Free Radical Reactions with Peptides by Mass Spectrometry

1998 • 53 citations

The Reaction Rates of NO with Horseradish Peroxidase Compounds I and II

1999 • 47 citations

EPR Detection of Glutathionyl and Protein-tyrosyl Radicals during the Interaction of Peroxynitrite with Macrophages (J774)

2001 • 47 citations

Tyrosine Iminoxyl Radical Formation from Tyrosyl Radical/Nitric Oxide and Nitrosotyrosine

2001 • 39 citations

Characterization of Hydrogen Peroxide-Induced Apoptosis in Mouse Primary Cultured Hepatocytes.

2000 • 36 citations

Characterization of Semiquinone Free Radicals Formed from Stilbene Catechol Estrogens

1989 • 25 citations

Exposure to Hydrogen Peroxide Induces Cell Death via Apoptosis in Primary Cultured Mouse Hepatocytes.

1999 • 19 citations

Detecting proteins containing 3,4-dihydroxyphenylalanine by silver staining of polyacrylamide gels

1991 • 13 citations

Mass Spectral Analysis of Protein-based Radicals Using DBNBS

2001 • 13 citations