Evidence for a role of tachykinin NK2 receptors in mediating brief nociceptive inputs to rat dorsal horn (laminae III–V) neurons

Substance P: Localization in the Central Nervous System and in Some Primary Sensory Neurons

1975 • 1,029 citations

A Potent Nonpeptide Antagonist of the Substance P (NK ₁ ) Receptor

1991 • 875 citations

Effects of substance P on functionally identified units in cat spinal cord

1976 • 655 citations

Pharmacological properties of a potent and selective nonpeptide substance P antagonist.

1991 • 429 citations

Tachykinin antagonists

1994 • 356 citations

Cutaneous stimuli releasing immunoreactive substance P in the dorsal horn of the cat

1988 • 348 citations

Pharmacological receptors for substance P and neurokinins

1987 • 337 citations

Substance P-mediated slow excitatory postsynaptic potential elicited in dorsal horn neurons in vivo by noxious stimulation.

1991 • 237 citations

Slow excitatory transmission in rat dorsal horn: possible mediation by peptides

1984 • 230 citations

Release of immunoreactive substance P in the spinal cord during development of acute arthritis in the knee joint of the cat: a study with antibody microprobes

1990 • 220 citations

Release, spread and persistence of immunoreactive neurokinin A in the dorsal horn of the cat following noxious cutaneous stimulation. Studies with antibody microprobes

1990 • 213 citations

Stereospecific effects of a nonpeptidic NK1 selective antagonist, CP-96,345: Antinociception in the absence of motor dysfunction

1991 • 175 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 160 citations

Quantitative autoradiographic distribution of multiple neurokinin binding sites in rat spinal cord

1990 • 160 citations

Central neural mediators of secondary hyperalgesia following heat injury in rats: Neuropeptides and excitatory amino acids

1991 • 151 citations

Neurokinin and NMDA antagonists (but not a kainic acid antagonist) are antinociceptive in the mouse formalin model

1991 • 145 citations

Novel substance P antagonist, CP-96,345, blocks responses of cat spinal dorsal horn neurons to noxious cutaneous stimulation and to substance P

1991 • 136 citations

Stimulus specificity of peripherally evoked substance P release from the rabbit dorsal horn in situ

1989 • 130 citations

In vivo evidence for tachykininergic transmission using a new NK-2 receptor-selective antagonist, MEN 10,376.

1991 • 129 citations

Effect of a tachykinin antagonist on a nociceptive reflex in the isolated spinal cord‐tail preparation of the newborn rat.

1988 • 120 citations

The non‐peptide NK₁ receptor antagonist, (±)‐CP‐96,345, produces antinociceptive and anti‐oedema effects in the rat

1992 • 118 citations

The involvement of neurokinin receptor subtypes in somatosensory processing in the superficial dorsal horn of the cat

1990 • 114 citations

Antinociceptive effects of Ca2+ channel blockers

1992 • 113 citations

Receptor-selective, peptidase-resistant agonists at neurokinin NK-1 and NK-2 receptors: New tools for investigating neurokinin function

1991 • 109 citations

Pharmacological specificity of synthetic peptides as antagonists at tachykinin receptors

1988 • 106 citations

The substance P receptor antagonist CP-96,345 interacts with Ca2+ channels

1992 • 88 citations

Responses of functionally identified neurones in the dorsal horn of the cat spinal cord to substance P, neurokinin A and physalaemin

1991 • 88 citations

On the role of NK-2 tachykinin receptors in the mediation of spinal reflex excitability in the rat

1991 • 84 citations

Tachykinins modulate multiple ionic conductances in voltage-clamped rat spinal dorsal horn neurons

1989 • 83 citations

Behavioural and antinociceptive effects of intrathecally injected substance P analogues in mice

1985 • 57 citations

The specific antagonistic effect of intrathecal spantide II on substance P- and C-fiber conditioning stimulation-induced facilitation of the nociceptive flexor reflex in rat

1990 • 51 citations

Analgesic activities of spinal cord substance P antagonists implicate substance P as a neurotransmitter of pain sensation

1986 • 47 citations

Synaptic activation of dorsal horn neurons by selective C-fibre excitation with capsaicin in the mouse spinal cord in vitro

1992 • 47 citations

Activity of peptide and non-peptide antagonists at peripheral NK1 receptors

1992 • 43 citations

Pharmacological and Molecular Biological Studies on the Diversity of Rat Tachykinin NK‐2 Receptor Subtypes in Rat CNS, Duodenum, Vas Deferens, and Urinary Bladdera

1991 • 37 citations

Effects of N-methyl-d-aspartate antagonists and spantide on spinal reflexes and responses to substance p and capsaicin in isolated spinal cord preparations from mouse and rat

1990 • 35 citations

Activity of spantide I and II at various tachykinin receptors and NK-2 tachykinin receptor subtypes

1991 • 33 citations

D‐Arg¹, D‐Trp⁷⁹, Leu¹¹‐substance P (spantide) does not antagonize substance P‐induced hyperexcitability of the nociceptive flexion withdrawal reflex in the rat

1987 • 29 citations

The selective NK-2 receptor antagonist MEN 10,376 inhibits synaptic excitation of dorsal horn neurons evoked by C-fibre activation in the in vitro rat spinal cord

1992 • 15 citations

Role of substance P in nociception

1989 • 7 citations

Antinociceptive effects of racemic RP67580, but not racemic CP96345, on acetic acid-induced writhing and formalin paw in mice

1992 • 6 citations

Excitation of rat dorsal horn lamina I neurons by selective agonist at NK-2 but not NK-1 receptors

1992 • 2 citations

Neurokinin selective agonists. Discovery and pharmacologic applications

1988 • 2 citations