Preservation-induced liver injury. Clinical aspects, mechanisms and therapeutic approaches

Surg Clin North Am.

1986 • 8,793 citations

Pentoxifylline

1987 • 1,768 citations

PRINCIPLES OF SOLID-ORGAN PRESERVATION BY COLD STORAGE

1988 • 1,366 citations

PATHOGENESIS OF LIPOID NEPHROSIS: A DISORDER OF T-CELL FUNCTION

1974 • 1,152 citations

Role of tumor necrosis factor-alpha in the pathophysiologic alterations after hepatic ischemia/reperfusion injury in the rat.

1990 • 828 citations

Neutrophils contribute to ischemia/reperfusion injury in rat liver in vivo

1990 • 739 citations

Neutrophil and Kupffer cell-induced oxidant stress and ischemia-reperfusion injury in rat liver

1991 • 663 citations

Liver Transplantation

1989 • 557 citations

Blebbing, free Ca2+ and mitochondrial membrane potential preceding cell death in hepatocytes

1987 • 533 citations

Deleterious effects of oxygen radicals in ischemia/reperfusion. Resolved and unresolved issues.

1989 • 518 citations

SINUSOIDAL LINING CELL DAMAGE

1988 • 458 citations

THE PREDICTIVE VALUE OF DONOR LIVER BIOPSIES FOR THE DEVELOPMENT OF PRIMARY NONFUNCTION AFTER ORTHOTOPIC LIVER TRANSPLANTATION

1991 • 444 citations

Kupffer cell activation and endothelial cell damage after storage of rat livers: Effects of reperfusion

1991 • 409 citations

Extended Preservation of Human Liver Grafts With UW Solution

1989 • 405 citations

EXTENDED PRESERVATION OF THE LIVER FOR CLINICAL TRANSPLANTATION

1988 • 399 citations

PRIMARY NONFUNCTION OF HEPATIC ALLOGRAFTS WITH PREEXISTING FATTY INFILTRATION1

1989 • 364 citations

Reperfusion injury to endothelial cells following cold ischemic storage of rat livers

1989 • 356 citations

A Flexible Procedure for Multiple Cadaveric Organ Procurement

1984 • 310 citations

72-HOUR PRESERVATION OF THE CANINE PANCREAS

1987 • 288 citations

THE INFLUENCE OF PRESERVATION INJURY ON REJECTION IN THE HEPATIC TRANSPLANT RECIPIENT

1990 • 275 citations

PRESERVATION OF THE CANINE LIVER FOR 24–48 HOURS USING SIMPLE COLD STORAGE WITH UW SOLUTION

1988 • 270 citations

INCREASED MAJOR HISTOCOMPATIBILITY COMPLEX ANTIGEN EXPRESSION IN UNILATERAL ISCHEMIC ACUTE TUBULAR NECROSIS IN THE MOUSE

1990 • 260 citations

TREATMENT OF PRIMARY LIVER GRAFT NONFUNCTION WITH PROSTAGLANDIN E1

1989 • 256 citations

Role of free radicals in ischemia-reperfusion injury to the liver.

1986 • 253 citations

Intracellular pH during "chemical hypoxia" in cultured rat hepatocytes. Protection by intracellular acidosis against the onset of cell death.

1989 • 252 citations

ADENINE NUCLEOTIDE METABOLISM AND ITS RELATION TO ORGAN VIABILITY IN HUMAN LIVER TRANSPLANTATION1

1988 • 228 citations

Epsilon-aminocaproic Acid for Treatment of Fibrinolysis during Liver Transplantation

1987 • 228 citations

EFFECT OF COLD ISCHEMIA TIME ON THE EARLY OUTCOME OF HUMAN HEPATIC ALLOGRAFTS PRESERVED WITH UW SOLUTION

1991 • 223 citations

Orthotopic Liver Transplantation: A Pathological Study of 63 Serial Liver Biopsies from 17 Patients with Special Reference to the Diagnostic Features and Natural History of Rejection†

1984 • 216 citations

The Relation of Leukotrienes to Liver Injury

1985 • 211 citations

Plasma membrane bleb formation and rupture: A common feature of hepatocellular injury

1990 • 209 citations

Host Biochemical Defense Mechanisms Against Prooxidants

1988 • 200 citations

HEPATIC REPERFUSION INJURY FOLLOWING ORTHOTOPIC LIVER TRANSPLANTATION IN THE RAT

1988 • 196 citations

Pathology of hepatic transplantation: A review of 62 adult allograft recipients immunosuppressed with a cyclosporine/steroid regimen.

1985 • 193 citations

Selective loss of nonparenchymal cell viability after cold ischemic storage of rat livers.

1988 • 179 citations

LIGNOCAINE METABOLITE FORMATION AS A MEASURE OF PRE-TRANSPLANT LIVER FUNCTION

1989 • 177 citations

INCREASE IN SURVIVAL TIME OF LIVER TRANSPLANTS BY PROTEASE INHIBITORS AND A CALCIUM CHANNEL BLOCKER, NISOLDIPINE

1990 • 160 citations

SELECTIVE LOSS OF NONPARENCHYMAL CELL VIABILITY AFTER COLD ISCHEMIC STORAGE OF RAT LIVERS

1988 • 153 citations

Cytoprotective actions of prostacyclin during hypoxia in the isolated perfused cat liver

1980 • 153 citations

Analysis of donor criteria for the prediction of outcome in clinical liver transplantation.

1987 • 150 citations

Early midzonal cell death during low-flow hypoxia in the isolated, perfused rat liver: Protection by allopurinol

1988 • 139 citations

Bile flow—An index of ischemic injury

1987 • 139 citations

Evaluation of Protocol Before Transplantation and After Reperfusion Biopsies From Human Orthotopic Liver Allografts: Considerations of Preservation and Early Immunological Injury

1990 • 139 citations

RELIABLE INDICES FOR THE DETERMINATION OF VIABILITY OF GRAFTED LIVER IMMEDIATELY AFTER ORTHOTOPIC TRANSPLANTATION BILE FLOW RATE AND CELLULAR ADENOSINE TRIPHOSPHATE LEVEL

1988 • 134 citations

AN ANALYSIS OF THE COMPONENTS IN UW SOLUTION USING THE ISOLATED PERFUSED RABBIT LIVER

1988 • 134 citations

MARKERS OF ALLOGRAFT VIABILITY IN THE RAT RELATIONSHIP BETWEEN TRANSPLANTATION VIABILITY AND LIVER FUNCTION IN THE ISOLATED PERFUSED LIVER

1987 • 133 citations

EVIDENCE THAT GRAFT SURVIVAL IS NOT RELATED TO PARENCHYMAL CELL VIABILITY IN RAT LIVER TRANSPLANTATION

1989 • 133 citations

THE USE OF OLDER DONOR LIVERS FOR HEPATIC TRANSPLANTATION

1990 • 128 citations

Ischemia-reperfusion injury: A radical view

1988 • 127 citations

CORRELATION BETWEEN CELLULAR ATP LEVEL AND BILE EXCRETION IN THE RAT LIVER

1985 • 122 citations

24-HOUR RAT LIVER PRESERVATION USING UW SOLUTION AND SOME SIMPLIFIED VARIANTS

1989 • 108 citations

CANINE AND HUMAN LIVER PRESERVATION FOR 6 TO 18 HR BY COLD INFUSION

1977 • 107 citations

Hemostasis in liver transplantation

1989 • 104 citations

ADENINE NUCLEOTIDE TISSUE CONCENTRATIONS AND LIVER ALLOGRAFT VIABILITY AFTER COLD PRESERVATION AND WARM ISCHEMIA

1988 • 103 citations

THE EFFECTS OF FASTING ON THE QUALITY OF LIVER PRESERVATION BY SIMPLE COLD STORAGE

1990 • 99 citations

Fructose prevents hypoxic cell death in liver

1987 • 98 citations

AUGMENTATION OF RAT LIVER REGENERATION BY FK 506 COMPARED WITH CYCLOSPORIN

1989 • 97 citations

Hepatic Retransplantation.

1985 • 97 citations

Hypothermic preservation of hepatocytes

1989 • 97 citations

CYTOPROTECTIVE EFFECT OF PROSTAGLANDIN I2 ON ISCHEMIA-INDUCED HEPATIC CELL INJURY

1983 • 95 citations

Antiperoxidant effects of dihydropyridine calcium antagonists

1989 • 92 citations

Liver preservation: The past and the future

1991 • 90 citations

Purine Nucleoside Phosphorylase: A New Marker for Free Oxygen Radical Injury to the Endothelial Cell

1990 • 84 citations

Regulation of the proliferation of primary rat hepatocytes by eicosanoids

1988 • 82 citations

A comparison of cold storage solutions for hepatic preservation using the isolated perfused rabbit liver

1988 • 78 citations

Mediators of Ischemic Renal Injury

1988 • 78 citations

Cholestatic jaundice after hepatic transplantation

1986 • 76 citations

Reactive oxygen intermediates and liver injury

1988 • 75 citations

TIME-RELATED MORPHOLOGICAL CHANGES IN COLD-STORED RAT LIVERS

1990 • 72 citations

Viability of sinusoidal lining cells in cold-preserved rat liver allografts.

1990 • 69 citations

Organ Preservation

1986 • 68 citations

EVIDENCE THAT CAROLINA RINSE SOLUTION PROTECTS SINUSOIDAL ENDOTHELIAL CELLS AGAINST REPERFUSION INJURY AFTER COLD ISCHEMIC STORAGE OF RAT LIVER

1990 • 67 citations

COMPARISON OF UW SOLUTION AND EURO-COLLINS SOLUTIONS FOR COLD PRESERVATION OF HUMAN LIVER GRAFTS

1990 • 65 citations

Evidence that Carolina rinse solution protects sinusoidal endothelial cells against reperfusion injury after cold ischemic storage of rat liver.

1990 • 65 citations

EVIDENCE THAT COLD PRESERVATION-INDUCED MICROCIRCULATORY INJURY IN LIVER ALLOGRAFTS IS NOT MEDIATED BY OXYGEN-FREE RADICALS OR CELL SWELLING IN THE RAT

1989 • 61 citations

Blood level of mitochondrial aspartate aminotransferase as an indicator of the extent of ischemic necrosis of the rat liver

1986 • 60 citations

THE BENEFICIAL EFFECT OF CYCLOSPORINE ON LIVER ISCHEMIA IN RATS

1989 • 60 citations

VIABILITY OF SINUSOIDAL LINING CELLS IN COLD-PRESERVED RAT LIVER ALLOGRAFTS

1990 • 58 citations

INCREASE IN SURVIVAL OF LIVER GRAFTS AFTER RINSING WITH WARM RINGERʼS SOLUTION DUE TO IMPROVEMENT OF HEPATIC MICROCIRCULATION

1991 • 57 citations

Hepatic circulation: Potential for therapeutic intervention

1990 • 56 citations

Creatine kinase-BB: A marker of liver sinusoidal damage in ischemia-reperfusion

1993 • 55 citations

Hypothermic preservation of hepatocytes. III. Effects of resuspension media on viability after up to 7 days of storage

1991 • 54 citations

Acidosis protects against lethal oxidative injury of liver sinusoidal endothelial cells

1991 • 53 citations

LIVER PRESERVATION WITH UW SOLUTION

1990 • 53 citations

Effect of oxidized and reduced glutathione in liver preservation

1990 • 53 citations

THE IMPACT OF EXTENDED PRESERVATION ON CLINICAL LIVER TRANSPLANTATION

1990 • 53 citations

The involvement of reactive oxygen species in hypoxic injury to rat liver.

1988 • 52 citations

Transplantation of the Liver

1989 • 50 citations

Primary culture of adult rat hepatocytes after 48-hour preservation of the liver with cold UW solution

1990 • 49 citations

PRESERVBATION DAMAGE IN LIVER TRANSPLANTATION Influence of rapid cooling

1986 • 48 citations

Role of purines and xanthine oxidase in reperfusion injury in perfused rat liver.

1989 • 45 citations

Protective effect of vasodilators on liver function after long hypothermic preservation: A study in the isolated perfused rat liver

1989 • 43 citations

Preservation damage in liver transplantation: electron-microscopic findings.

1984 • 43 citations

Thrombocytopenia after liver transplantation.

1988 • 40 citations

Functional and morphological features of isolated hepatocytes preserved in university of wisconsin solution

1991 • 40 citations

Whole body gas exchange: amino acid and lactate clearance as indicators of initial and early allograft viability in liver transplantation.

1989 • 35 citations

Ultrastructural changes in the rat liver during Euro-Collins storage, compared with hypothermic in vitro ischemia

1987 • 34 citations

Improved Hepatic Function in the 24-Hour Preserved Rat Liver With UW-Lactobionate Solution and SRI 63-441

1988 • 33 citations

Protective effect of nifedipine in the hypoxic perfused cat liver

1981 • 31 citations

The Protective Effect of Administered α‐Tocopherol against Hepatic Damage Caused by Ischemia‐Reperfusion or Endotoxemia

1989 • 31 citations

Use of quantitative liver function tests ? caffeine clearance and galactose elimination capacity ? after orthotopic liver transplantation

1990 • 31 citations

Cyclosporine augments hepatic regenerative response in rats

1990 • 30 citations

Changes in coagulation and fibrinolysis after orthotopic canine liver homotransplantation.

1969 • 29 citations

Altered hepatic junctional permeability, bile acid excretion and glutathione efflux during oxidant challenge.

1989 • 27 citations

ADDITIVE INHIBITION OF AFFERENT AND EFFERENT IMMUNOLOGICAL RESPONSES OF HUMAN PERIPHERAL BLOOD MONONUCLEAR CELLS BY VERAPAMIL AND CYCLOSPORINE

1991 • 22 citations

FK 506 ameliorates the hepatic injury associated with ischemia

1990 • 20 citations

Hypothermic preservation of the rat liver assessed by orthotopic transplantation. A comparison of flush solutions.

1986 • 19 citations

Effects of chlorpromazine and methylprednisolone on perfusion preservation of rabbit livers

1988 • 19 citations

Rat kidney preservation with UW solution.

1989 • 18 citations

Reliability of the MEGX test in the selection of liver grafts.

1991 • 18 citations

Estimation of the fractional catabolic rate constants for the elimination of cytosolic liver enzymes from plasma

1989 • 18 citations

Prostaglandin E2 increases the tolerance of the rat liver to warm ischemia in absence of splanchnic congestion.

1987 • 15 citations

HYPOTHERMIC PRESERVATION OF THE RAT LIVER ASSESSED BY ORTHOTOPIC TRANSPLANTATION

1986 • 15 citations

Effect of bile acids on ischemia-reperfusion liver injury

1991 • 15 citations

Effects of hepatic ischemia on coagulation in primates. Application to liver transplantation.

1970 • 14 citations

Arterial Blood Ketone Body Ratio as an Indicator for Viability of Donor Livers

1992 • 14 citations

Quantitative analysis of the effect of ATP-MgCl2 and adenosine-MgCl2 on the extent of necrosis in rat liver after ischemia

1986 • 13 citations

Beneficial actions of two novel calcium entry blockers in the isolated perfused hypoxic cat liver.

1985 • 13 citations

Orthotopic liver transplantation: an experimental study on mechanisms of hemorrhagic diathesis and thrombosis.

1975 • 13 citations

INTRAOPERATIVE EVALUATION OF EUROCOLLINS AND UNIVERSITY OF WISCONSIN PRESERVATION SOLUTIONS IN PATIENTS UNDERGOING HEPATIC TRANSPLANTATION

1990 • 13 citations

Influence of donor data on the outcome of liver transplantation.

1991 • 12 citations

The effect of isoproterenol and Collins' solution on the preservation of canine livers with simple cooling.

1974 • 12 citations

Comparative evaluation of Euro-Collins, UW solution, and UW solution without hydroxyethyl starch in orthotopic liver transplantation in the rat.

1990 • 11 citations

Functional and morphological features of isolated hepatocytes preserved in university of Wisconsin solution,

1991 • 10 citations

Successful liver allograft function after 24-hour preservation: cumulative effects of prostacyclin plus verapamil.

1987 • 10 citations

Nitrendipine Protects the Liver Against Hypoxia-Induced Damage at Submicromolar Concentrations in the Perfused Rat Liver

1987 • 10 citations

Coagulation factors as indicators of early graft function following liver transplantation.

1989 • 9 citations

Hepatic preservation with University of Wisconsin solution is associated with reduced allograft rejection.

1991 • 8 citations

The beneficial effect of superoxide dismutase on the rat liver graft

1989 • 8 citations

A RAT LIVER PRESERVATION EXPERIMENT

1990 • 7 citations

Transplantation hépatique chez l'adulte : prise en charge postopératoire et évolution au cours des premiers mois

1989 • 6 citations

Clinicopathological approach to human liver allograft dysfunction

1989 • 5 citations

Comparison of Ringer's lactate versus UW solution as flushing solutions assessed in the isolated perfused rat liver.

1990 • 3 citations

Effect of the initial cooling solution on 24‐hour liver preservation with UW solution

1989 • 3 citations

Ischemia-reperfusion liver injury: The role of cysteinyl-leukotrienes (LT)

1990 • 2 citations