FRETS‐VWF73, a first fluorogenic substrate for ADAMTS13 assay

Antibodies to von Willebrand Factor–Cleaving Protease in Acute Thrombotic Thrombocytopenic Purpura

1998 • 1,749 citations

Mutations in a member of the ADAMTS gene family cause thrombotic thrombocytopenic purpura

2001 • 1,715 citations

von Willebrand Factor–Cleaving Protease in Thrombotic Thrombocytopenic Purpura and the Hemolytic–Uremic Syndrome

1998 • 1,630 citations

Unusually Large Plasma Factor VIII: von Willebrand Factor Multimers in Chronic Relapsing Thrombotic Thrombocytopenic Purpura

1982 • 1,105 citations

Partial purification and characterization of a protease from human plasma cleaving von Willebrand factor to fragments produced by in vivo proteolysis

1996 • 893 citations

Structure of von Willebrand Factor-cleaving Protease (ADAMTS13), a Metalloprotease Involved in Thrombotic Thrombocytopenic Purpura

2001 • 827 citations

Physiologic cleavage of von Willebrand factor by a plasma protease is dependent on its conformation and requires calcium ion

1996 • 785 citations

ADAMTS13 activity in thrombotic thrombocytopenic purpura–hemolytic uremic syndrome: relation to presenting features and clinical outcomes in a prospective cohort of 142 patients

2003 • 675 citations

Changes in health and disease of the metalloprotease that cleaves von Willebrand factor

2001 • 503 citations

Effect of plasma exchange on plasma ADAMTS13 metalloprotease activity, inhibitor level, and clinical outcome in patients with idiopathic and nonidiopathic thrombotic thrombocytopenic purpura

2004 • 445 citations

Shear stress enhances the proteolysis of von Willebrand factor in normal plasma

1994 • 408 citations

Mutations and common polymorphisms in ADAMTS13 gene responsible for von Willebrand factor-cleaving protease activity

2002 • 407 citations

Specific von Willebrand factor–cleaving protease in thrombotic microangiopathies: a study of 111 cases

2001 • 391 citations

Hyaline thrombosis of the terminal arterioles and capillaries : a hitherto undescribed disease

1924 • 379 citations

Hyalin thrombosis of the terminal arterioles and capillaries : A hitherto undescribed disease

1924 • 356 citations

Identification of a cleavage site directing the immunochemical detection of molecular abnormalities in type IIA von Willebrand factor.

1990 • 347 citations

A Novel Human Metalloprotease Synthesized in the Liver and Secreted into the Blood: Possibly, the von Willebrand Factor--Cleaving Protease?

2001 • 335 citations

Prevalence of Asymptomatic Carotid Atherosclerotic Lesions Detected by High-Resolution Ultrasonography and Its Relation to Cardiovascular Risk Factors in the General Population of a Japanese City

1997 • 315 citations

Assay of von Willebrand Factor (vWF)-cleaving Protease Based on Decreased Collagen Binding Affinity of Degraded vWF

1999 • 303 citations

Cloning, expression, and functional characterization of the von Willebrand factor–cleaving protease (ADAMTS13)

2002 • 232 citations

von Willebrand factor cleaving protease and ADAMTS13mutations in childhood TTP

2003 • 221 citations

VWF73, a region from D1596 to R1668 of von Willebrand factor, provides a minimal substrate for ADAMTS-13

2003 • 176 citations

Molecular characterization of ADAMTS13 gene mutations in Japanese patients with Upshaw-Schulman syndrome

2003 • 149 citations

Binding of platelet glycoprotein Ibα to von Willebrand factor domain A1 stimulates the cleavage of the adjacent domain A2 by ADAMTS13

2004 • 149 citations

Estimation of the von Willebrand Factor-cleaving Protease in Plasma Using Monoclonal Antibodies to vWF

1999 • 111 citations

ADAMTS13 gene defects in two brothers with constitutional thrombotic thrombocytopenic purpura and normalization of von Willebrand factor‐cleaving protease activity by recombinant human ADAMTS13

2003 • 104 citations

Evaluation and clinical application of a new method for measuring activity of von Willebrand factor-cleaving metalloprotease (ADAMTS13)

2002 • 97 citations

Measurement of von Willebrand factor-cleaving protease (ADAMTS-13) activity in plasma: a multicenter comparison of different assay methods

2003 • 95 citations

Measurement of von Willebrand factor cleaving protease (ADAMTS‐13): results of an international collaborative study involving 11 methods testing the same set of coded plasmas

2004 • 95 citations

Congenital thrombotic thrombocytopenic purpura in association with a mutation in the second CUB domain of ADAMTS13

2003 • 92 citations

Mutation analysis and clinical implications of von Willebrand factor–cleaving protease deficiency

2003 • 89 citations

Molecular modeling of the von Willebrand factor A2 Domain and the effects of associated type 2A von Willebrand disease mutations

2004 • 78 citations

ADAMTS13 gene mutation in congenital thrombotic thrombocytopenic purpura with previously reported normal VWF cleaving protease activity

2003 • 75 citations

Identification of Strain-specific Variants of Mouse Adamts13 Gene Encoding von Willebrand Factor-cleaving Protease

2004 • 68 citations

Molecular Modeling of Ligand and Mutation Sites of the Type A Domains of Human von Willebrand Factor and Their Relevance to von Willebrand's Disease

1998 • 58 citations

Assays of von Willebrand Factor- Cleaving Protease: A Test for Diagnosis of Familial and Acquired Thrombotic Thrombocytopenic Purpura

2002 • 27 citations

ADAMTS13 and TTP: the clot thickens

2004 • 5 citations