Pharmacokinetic/pharmacodynamic modeling of antitumor agents encapsulated into liposomes

A pharmacokinetic analysis program (multi) for microcomputer.

1981 • 2,465 citations

Vascular permeability in a human tumor xenograft: molecular size dependence and cutoff size.

1995 • 1,682 citations

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

1991 • 1,591 citations

A clinicopathologic analysis of adriamycin cardiotoxicity

1973 • 1,534 citations

Determinants of tumor blood flow: a review.

1988 • 1,362 citations

Transport of molecules in the tumor interstitium: a review.

1987 • 1,360 citations

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

1994 • 904 citations

Liposomal doxorubicin: antitumor activity and unique toxicities during two complementary phase I studies.

1995 • 476 citations

Sterically Stabilized Anti-HER2 Immunoliposomes: Design and Targeting to Human Breast Cancer Cells in Vitro

1997 • 438 citations

Selective tumor localization and improved therapeutic index of anthracyclines encapsulated in long-circulating liposomes.

1992 • 422 citations

Increased microvascular permeability contributes to preferential accumulation of Stealth liposomes in tumor tissue.

1993 • 368 citations

Microscopic localization of sterically stabilized liposomes in colon carcinoma-bearing mice.

1992 • 303 citations

Implications of biochemical, cytokinetic, pharmacologic, and toxicologic relationships in the design of optimal therapeutic schedules.

1970 • 285 citations

Pharmacokinetics and therapeutics of sterically stabilized liposomes in mice bearing C-26 colon carcinoma.

1992 • 275 citations

In vitro and in vivo targeting of immunoliposomal doxorubicin to human B-cell lymphoma.

1998 • 260 citations

Development of anti-p185HER2 immunoliposomes for cancer therapy.

1995 • 258 citations

Characterization of liposomal systems containing doxorubicin entrapped in response to pH gradients

1990 • 239 citations

Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant sublines of P388 leukemia

1978 • 212 citations

Pharmacokinetics and Tissue Distribution of Doxorubicin Encapsulated in Stable Liposomes With Long Circulation Times

1989 • 210 citations

Bulk transfer of fluid in the interstitial compartment of mammary tumors.

1975 • 198 citations

A nonlinear least squares program based on differential equations, MULTI (RUNGE), for microcomputers.

1983 • 189 citations

Immunoliposomes bearing polyethyleneglycol‐coupled Fab′ fragment show prolonged circulation time and high extravasation into targeted solid tumors in vivo

1997 • 168 citations

Liposomal-entrapped doxorubicin: an active agent in AIDS-related Kaposi's sarcoma.

1995 • 163 citations

Pharmacodynamics of Chemotherapeutic Effects: Dose-Time-Response Relationships for Phase-Nonspecific Agents

1971 • 162 citations

Therapy of primary and metastatic mouse mammary carcinomas with doxorubicin encapsulated in long circulating liposomes

1992 • 153 citations

In vitro cytotoxicity of liposome-encapsulated doxorubicin: dependence on liposome composition and drug release

1992 • 136 citations

Comparative pharmacokinetics of free doxorubicin and doxorubicin entrapped in cardiolipin liposomes.

1986 • 128 citations

Pharmacokinetics and pharmacodynamics of doxorubicin in patients with small cell lung cancer

1993 • 127 citations

Long-circulating liposomes.

1994 • 126 citations

Clinical Pharmacokinetics-Pharmacodynamicsof Anticancer Drugs

1989 • 120 citations

Reduced cardiotoxicity and nephrotoxicity with preservation of antitumor activity of doxorubicin entrapped in stable liposomes in the LOU/M Wsl rat.

1984 • 117 citations

Validation of the fluorescent dye Hoechst 33342 as a vascular space marker in tumours

1988 • 111 citations

Fluorescence imaging studies for the disposition of daunorubicin liposomes (DaunoXome) within tumor tissue.

1996 • 108 citations

Exchange of macromolecules between peritoneal cavity and plasma

1985 • 105 citations

Arrest of human lung tumor xenograft growth in severe combined immunodeficient mice using doxorubicin encapsulated in sterically stabilized liposomes.

1993 • 104 citations

Efficacy and safety of Stealth liposomal doxorubicin in AIDS-related Kaposi's sarcoma

1996 • 103 citations

Tumor growth and chemotherapy: Mathematical methods, computer simulations, and experimental foundations

1973 • 102 citations

Therapy of human ovarian carcinoma xenografts using doxorubicin encapsulated in sterically stabilized liposomes

1993 • 98 citations

A pharmacodynamic model for cell-cycle-specific chemotherapeutic agents

1973 • 97 citations

Comparison of free and liposome encapsulated doxorubicin tumor drug uptake and antitumor efficacy in the SC115 murine mammary tumor

1990 • 92 citations

Doxorubicin: Effect of different schedules on toxicity and anti-tumor efficacy

1989 • 88 citations

Cell killing action of cell cycle phase-non-specific antitumor agents is dependent on concentration-time product

1988 • 88 citations

Dependence of the cytostatic effect of adriamycin on drug concentration and exposure time in vitro

1980 • 78 citations

Lymphatic absorption and tissue disposition of liposome-entrapped [14C]adriamycin following intraperitoneal administration to rats.

1981 • 71 citations

Effects of the size and fluidity of liposomes on their accumulation in tumors: A presumption of their interaction with tumors

1995 • 67 citations

Liposomal anthracyclines.

1994 • 61 citations

Transfer of liposomal drug carriers from the blood to the peritoneal cavity of normal and ascitic tumor-bearing mice

1994 • 59 citations

Intratumor distribution of doxorubicin following i.v. administration of drug encapsulated in egg phosphatidylcholine/cholesterol liposomes

1997 • 58 citations

Kinetic analysis of cell killing effect induced by cytosine arabinoside and cisplatin in relation to cell cycle phase specificity in human colon cancer and Chinese hamster cells.

1989 • 58 citations

Weekly doxorubicin in the treatment of patients with AIDS-related Kaposi's sarcoma. AIDS Clinical Trials Group.

1993 • 54 citations

Kinetic analysis of AUC-dependent saturable clearance of liposomes: Mathematical description of AUC dependency

1993 • 52 citations

Modulation of doxorubicin resistance in a doxorubicin-resistant human leukaemia cell by an immunoliposome targeting transferring receptor

1997 • 49 citations

Residence Time Distributions of various Tracers in Tumors: Implications for Drug Delivery and Blood Flow Measurement

1994 • 38 citations

Species difference in the disposition of liposomes among mice, rats, and rabbits: allometric relationship and species dependent hepatic uptake mechanism.

1996 • 30 citations

Kinetic analysis of tissue distribution of doxorubicin incorporated in liposomes in rats (II)

1993 • 22 citations

Free and Liposomal Doxorubicin Treatment of Intraperitoneal Colon 26 Tumor: Therapeutic and Pharmacologic Studies

1990 • 17 citations

Endocytosis does not necessarily augment the cytotoxicity of adriamycin encapsulated in immunoliposomes

1994 • 16 citations

Pharmacokinetic analysis of drug disposition after intratumoral injection in a tissue-isolated tumor perfusion system.

1996 • 13 citations

Quantitative clonal growth of mammalian cells: its application for quantitative study of cytocidal action of Mitomycin-C.

1972 • 12 citations

Evaluation of the Efficiency of Targeting of Antitumor Drugs: Simulation Analysis Based on Pharmacokinetic/Pharmacodynamic Considerations

1996 • 9 citations

Uptake and retention of adriamycin and daunorubicin by sensitive and anthracycline-resistant subline of P388 leukemia.

1978 • 4 citations

Kinetic study on the optimization of tumor delivery of antitumor agents by liposomes: Simulation study based on the physiological modeling.

1997 • 3 citations

Doxorubicin weekly low dose administration: in vitro cytotoxicity generated by the typical pharmacokinetic profile

1992 • 3 citations