UCN-01 (7-hydroxystaurosporine) inhibits the growth of human breast cancer xenografts through disruption of signal transduction

The retinoblastoma protein and cell cycle control

1995 • 4,873 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

PROTOCOLS FOR SCREENING CHEMICAL AGENTS AND NATURAL PRODUCTS AGAINST ANIMAL TUMORS AND OTHER BIOLOGICAL SYSTEMS

1972 • 1,130 citations

A novel cyclin associates with M015/CDK7 to form the CDK-activating kinase

1994 • 636 citations

DRTF1/E2F: an expanding family of heterodimeric transcription factors implicated in cell-cycle control

1994 • 323 citations

Cyclins, Cyclin-Dependent Kinases and Cdk Inhibitors: Implications in Cell Cycle Control and Cancer

1995 • 314 citations

Chemotherapy of human tumor xenografts in genetically athymic mice.

1978 • 194 citations

UCN-01, a selective inhibitor of protein kinase C from Streptomyces.

1987 • 189 citations

Antitumor activity of UCN-01, a selective inhibitor of protein kinase C, in murine and human tumor models.

1991 • 187 citations

G1 phase accumulation induced by UCN-01 is associated with dephosphorylation of Rb and CDK2 proteins as well as induction of CDK inhibitor p21/Cip1/WAF1/Sdi1 in p53-mutated human epidermoid carcinoma A431 cells.

1997 • 155 citations

Cell cycle arrest and growth inhibition by the protein kinase antagonist UCN-01 in human breast carcinoma cells.

1993 • 133 citations

Enhancement of antitumor activity of mitomycin C in vitro and in vivo by UCN-01, a selective inhibitor of protein kinase C

1993 • 119 citations

UCN-01, 7-Hydroxyl-staurosporine, Inhibits Kinase Activity of Cyclin-Dependent Kinases and Reduces the Phosphorylation of the Retinoblastoma Susceptibility Gene Product in A549 Human Lung Cancer Cell Line

1996 • 117 citations

Effect of UCN-01, a selective inhibitor of protein kinase C, on the cell-cycle distribution of human epidermoid carcinoma, A431 cells

1994 • 92 citations

Hormone dependency of a serially transplantable human breast cancer (Br-10) in nude mice.

1977 • 33 citations

Human breast carcinoma (MCF-7) serially transplanted into nude mice

1983 • 31 citations

UCN‐01 (7‐Hydoxystaurosporine) Inhibits in vivo Growth of Human Cancer Cells through Selective Perturbation of G1 Phase Checkpoint Machinery

2001 • 19 citations

UCN‐01 (7‐Hydroxystaurosporine) Enhances 5‐Fluorouracil Cytotoxicity through Down‐regulation of Thymidylate Synthetase Messenger RNA

2000 • 14 citations

Synergistic antitumor effect of UCN-01, a protein kinase (C) inhibitor, combined with various anti-cancer agents

1993 • 10 citations

[Experimental chemo- and chemoendocrine therapy of human breast carcinomas serially transplanted into nude mice].

1988 • 4 citations

Cyclins, cyclin-dependent kinases and CDK inhibitors : implications in cell cycle control and cancer

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[Experimental chemotherapy of human breast carcinomas transplanted into nude mice].

1984 • 2 citations