Tn10 insertion specificity is strongly dependent upon sequences immediately adjacent to the target-site consensus sequence.

[19] Rapid and efficient site-specific mutagenesis without phenotypic selection

1987 • 5,413 citations

Gene organization and primary structure of a ribosomal RNA operon from Escherichia coli

1981 • 1,732 citations

Improved single and multicopy lac-based cloning vectors for protein and operon fusions

1987 • 1,537 citations

Sequence-specific recognition of double helical nucleic acids by proteins.

1976 • 1,123 citations

Information content of binding sites on nucleotide sequences

1986 • 953 citations

Studies on the cleavage of bacteriophage lambda DNA with EcoRI restriction endonuclease

1975 • 798 citations

Structure of the DNA-Eco RI Endonuclease Recognition Complex at 3 Å Resolution

1986 • 492 citations

[7] Uses of transposons with emphasis on Tn10

1991 • 412 citations

A General Method for Saturation Mutagenesis of Cloned DNA Fragments

1985 • 292 citations

Searching for and predicting the activity of sites for DNA binding proteins: compilation and analysis of the binding sites forEscherichia coliintegration host factor (IHF)

1990 • 289 citations

Gene regulation at the right operator (OR) of bacteriophage λ

1980 • 243 citations

Genetic organization of transposon Tn10

1981 • 198 citations

A symmetrical six-base-pair target site sequence determines Tn10 insertion specificity

1982 • 181 citations

DNA sequence organization of IS 10 -right of Tn 10 and comparison with IS 10 -left

1982 • 126 citations

Escherichia coli integration host factor binds specifically to the ends of the insertion sequence IS1 and to its major insertion hot-spot in pBR322

1987 • 111 citations

DNA determinants important in sequence recognition by Eco RI endonuclease.

1981 • 107 citations

Mutations in the lactose operon caused by bacteriophage Mu

1972 • 104 citations

A Tn 10-lacZ-kanR-URA3 Gene Fusion Transposon for Insertion Mutagenesis and Fusion Analysis of Yeast and Bacterial Genes

1987 • 100 citations

Mutational analysis of IS10′s outside end.

1989 • 94 citations

Intramolecular transposition by Tn10

1989 • 94 citations

DNA sequence analysis of Tn10 insertions: Origin and role of 9 bp flanking repetitions during Tn10 translocation

1979 • 89 citations

IS10 transposase mutations that specifically alter target site recognition.

1992 • 71 citations

SPECIFICITY OF INSERTION BY THE TRANSLOCATABLE TETRACYCLINE-RESISTANCE ELEMENT Tn10

1979 • 67 citations

The influence of sequences adjacent to the recognition site on the cleavage of oligodeoxynucleotides by the EcoRI endonuclease

1984 • 67 citations

Substrate dependence of the mechanism of EcoRI endonuclease

1978 • 65 citations

Excision of Tn10 from the donor site during transposition occurs by flush double-strand cleavages at the transposon termini.

1992 • 57 citations

A New Generalizable Test for Detection of Mutations Affecting Tn10 Transposition

1987 • 48 citations

Transcriptional occlusion of transposon targets

1989 • 39 citations

Efficient Tn10 transposition into a DNA insertion hot spot in vivo requires the 5-methyl groups of symmetrically disposed thymines within the hot-spot consensus sequence.

1987 • 27 citations

Genetic evidence against intramolecular rejoining of the donor DNA molecule following IS10 transposition.

1991 • 23 citations