Effect of a protein binding change on unbound and total plasma concentrations for drugs of intermediate hepatic extraction

Simultaneous Statistical Inference

1981 • 5,665 citations

Hepatic clearance of drugs. I. Theoretical considerations of a “well-stirred” model and a “parallel tube” model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance

1977 • 753 citations

Mechanisms of bile formation, hepatic uptake, and biliary excretion.

1984 • 375 citations

Plasma protein binding of basic drugs

1977 • 228 citations

Applied Clinical Pharmacokinetics

2002 • 195 citations

Isolated liver perfusion and its applications

1973 • 191 citations

Free Drug Concentration Monitoring in Clinical Practice

1986 • 174 citations

The plasma protein binding of basic drugs.

1986 • 174 citations

Importance of Protein Binding for the Interpretation of Serum or Plasma Drug Concentrations

1982 • 133 citations

Canalicular bile formation in the isolated perfused rat liver

1971 • 128 citations

Colorimetric determination of free fatty acids

1969 • 98 citations

Theoretic aspects of pharmacokinetic drug interactions

1977 • 83 citations

Effect of Sulfisoxazole on Pharmacokinetics of Free and Plasma Protein-Bound Bilirubin in Experimental Unconjugated Hyperbilirubinemia

1979 • 46 citations

Differential Effects of Hypoxia on the Disposition of Propranolol and Sodium Taurocholate by the Isolated Perfused Rat Liver

1984 • 46 citations

Effect of plasma protein binding on elimination of taurocholate by isolated perfused rat liver: Comparison of venous equilibrium, undistributed and distributed sinusoidal, and dispersion models

1988 • 33 citations

Drug interactions involving the displacement of drugs from plasma protein and tissue binding sites

1982 • 31 citations

ADVANCES IN PHARMACOLOGY AND THERAPEUTICS

1979 • 30 citations

Effect of Salicylic Acid on Pharmacokinetics of Free and Plasma Protein-Bound Bilirubin in Experimental Unconjugated Hyperbilirubinemia

1979 • 30 citations

Effect of plasma protein binding on quinidine kinetics in the rabbit.

1980 • 27 citations

Binding of sodium taurocholate by bovine serum albumin

1971 • 21 citations

Kinetics of drug-drug interactions

1981 • 16 citations

THE CLINICAL IMPORTANCE OF INTERACTIONS BASED ON DISPLACEMENT OF PROTEIN BOUND DRUGS

1978 • 9 citations