Insulin-Like Growth Factor-I and Binding Protein-3 and Risk of Cancer

Genetic Alterations during Colorectal-Tumor Development

1988 • 6,691 citations

Insulin-Like Growth Factors and Their Binding Proteins: Biological Actions*

1995 • 4,419 citations

Growth Factors and Cancer

1991 • 2,044 citations

Plasma Insulin-Like Growth Factor-I and Prostate Cancer Risk: A Prospective Study

1998 • 2,010 citations

Insulin-like growth factors and their binding proteins: biological actions

1995 • 1,976 citations

Circulating concentrations of insulin-like growth factor I and risk of breast cancer

1998 • 1,850 citations

Effects of Human Growth Hormone in Men over 60 Years Old

1990 • 1,560 citations

Prospective Study of Colorectal Cancer Risk in Men and Plasma Levels of Insulin-Like Growth Factor (IGF)-I and IGF-Binding Protein-3

1999 • 1,128 citations

Physical Activity, Obesity, and Risk for Colon Cancer and Adenoma in Men

1995 • 1,014 citations

Insulin-like Growth Factor (IGF)-binding Protein-3 Induces Apoptosis and Mediates the Effects of Transforming Growth Factor-β1 on Programmed Cell Death through a p53- and IGF-independent Mechanism

1997 • 725 citations

Serum insulin-like growth factor-I in 1030 healthy children, adolescents, and adults: relation to age, sex, stage of puberty, testicular size, and body mass index

1994 • 696 citations

Insulin-Like Growth Factor 1 and Prostate Cancer Risk: A Population-Based, Case-Control Study

1998 • 592 citations

Plasma Levels of Insulin-Like Growth Factor-I and Lung Cancer Risk: a Case-Control Analysis

1999 • 558 citations

The insulin-like growth factor I receptor: a key to tumor growth?

1995 • 549 citations

Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation.

1995 • 439 citations

Dietary components that regulate serum somatomedin-C concentrations in humans.

1983 • 433 citations

Insulin-like growth factor 1 in relation to prostate cancer and benign prostatic hyperplasia

1997 • 376 citations

Genetic and environmental components of interindividual variation in circulating levels of IGF-I, IGF-II, IGFBP-1, and IGFBP-3.

1996 • 330 citations

Effect of Tamoxifen on Serum Insulinlike Growth Factor I Levels in Stage I Breast Cancer Patients

1990 • 264 citations

Acromegaly and gastrointestinal cancer

1991 • 249 citations

Epidemiology of Insulin-like Growth Factor-I in Elderly Men and Women: The Rancho Bernardo Study

1997 • 241 citations

The ratio between serum levels of insulin‐like growth factor (IGF)‐I and the IGF binding proteins (IGFBP‐1, 2 and 3) decreases with age in healthy adults and is increased in acromegalic patients

1994 • 232 citations

Acromegaly, colonic polyps and carcinoma

1997 • 227 citations

Estradiol and Antiestrogens Regulate a Growth Inhibitory Insulin-like Growth Factor Binding Protein 3 Autocrine Loop in Human Breast Cancer Cells

1996 • 225 citations

Use of plasma somatomedin-C/insulin-like growth factor I measurements to monitor the response to nutritional repletion in malnourished patients

1985 • 214 citations

Adult stature and risk of cancer.

1988 • 213 citations

Insulin-like growth factor-I in relation to premenopausal ductal carcinoma in situ of the breast.

1998 • 209 citations

Insulin and Insulin‐like Growth Factor 1 Stimulate Proliferation of Metastatic Variants of Colon Carcinoma 26

1989 • 181 citations

Characterization of insulinlike growth factor I receptors in human colon cancer

1992 • 174 citations

Serum levels of insulin-like growth factor (IGF)-binding protein-3 (IGFBP-3) in healthy infants, children, and adolescents: the relation to IGF-I, IGF-II, IGFBP-1, IGFBP-2, age, sex, body mass index, and pubertal maturation

1995 • 168 citations

Colonie Polyps in Patients with Acromegaly

1982 • 162 citations

Nutrition and somatomedin. XIII. Usefulness of somatomedin-C in nutritional assessment

1985 • 158 citations

Presence of somatomedin receptors on primary human breast and colon carcinomas

1987 • 141 citations

Benign and Malignant Tumors in Patients With Acromegaly

1991 • 134 citations

A prospective study of body mass, height, and smoking on the risk of colorectal cancer in women

1991 • 133 citations

Acromegaly and Colon Cancer

1984 • 126 citations

Increased epithelial cell proliferation in the colon of patients with acromegaly.

1996 • 119 citations

Caloric restriction and 7,12-dimethylbenz(a)anthracene-induced mammary tumor growth in rats: alterations in circulating insulin, insulin-like growth factors I and II, and epidermal growth factor.

1989 • 116 citations

Growth-Regulatory Effects of Sensory Neuropeptides, Epidermal Growth Factor, Insulin, and Somatostatin on the Non-Transformed Intestinal Epithelial Cell Line IEC-6 and the Colon Cancer Cell Line HT 29

1993 • 115 citations

Characterization of the synergistic effect of insulin and transferrin and the regulation of their receptors on a human colon carcinoma cell line

1990 • 105 citations

COLON CANCER AND POLYPS IN ACROMEGALY: INCREASED RISK ASSOCIATED WITH FAMILY HISTORY OF COLON CANCER

1990 • 103 citations

Adult height and incidence of cancer in male physicians (United States).

1997 • 100 citations

Synthesis and biological activities of highly potent antagonists of growth hormone-releasing hormone.

1994 • 97 citations

Somatostatin analogue SMS 201-995 reduces serum IGF-I levels in patients with neoplasms potentially dependent on IGF-I.

1989 • 96 citations

A randomised trial of octreotide vs best supportive care only in advanced gastrointestinal cancer patients refractory to chemotherapy

1995 • 75 citations

Gastrointestinal tumors in acromegalic patients.

1985 • 74 citations

The insulin-like growth factor system in the prostate

1995 • 71 citations

High Prevalence of Colonic Polyps in Patients With Acromegaly

1994 • 67 citations

A role for insulin-like growth factor binding protein 5 in the antiproliferative action of the antiestrogen ICI 182780.

1996 • 66 citations

Management of colorectal polyps

1997 • 65 citations

SMS 201.995 inhibits in vitro and in vivo growth of human colon cancer.

1992 • 64 citations

Reduction of Enhanced Mammary Carcinogenesis in LA/N-cp (Corpulent) Rats by Energy Restriction

1991 • 53 citations

Inhibition of tumor cell kinetics and serum insulin growth factor I levels by octreotide in colorectal cancer patients

1997 • 33 citations

High prevalence of colonic polyps in patients with acromegaly. Influence of sex and age

1994 • 22 citations

Serum Concentrations of Insulin-Like Growth Factor 1 in Colonic Neoplasia

1994 • 15 citations