Molecular mechanisms underlying activity-dependent regulation of BDNF expression

Long‐lasting potentiation of synaptic transmission in the dentate area of the anaesthetized rabbit following stimulation of the perforant path

1973 • 7,118 citations

Phosphorylated CREB binds specifically to the nuclear protein CBP

1993 • 2,039 citations

Ca2+ Influx Regulates BDNF Transcription by a CREB Family Transcription Factor-Dependent Mechanism

1998 • 1,504 citations

Deficient Hippocampal Long-Term Potentiation in α-Calcium-Calmodulin Kinase II Mutant Mice

1992 • 1,458 citations

Calcium Signaling in Neurons: Molecular Mechanisms and Cellular Consequences

1995 • 1,421 citations

Hippocampal long-term potentiation is impaired in mice lacking brain-derived neurotrophic factor.

1995 • 1,416 citations

Binding of a nuclear protein to the cyclic-AMP response element of the somatostatin gene

1987 • 1,364 citations

Long-lasting neurotrophin-induced enhancement of synaptic transmission in the adult hippocampus

1995 • 1,354 citations

Recombinant BDNF Rescues Deficits in Basal Synaptic Transmission and Hippocampal LTP in BDNF Knockout Mice

1996 • 1,219 citations

CREB Phosphorylation and Dephosphorylation: A Ca2+- and Stimulus Duration–Dependent Switch for Hippocampal Gene Expression

1996 • 1,109 citations

Intracellular injections of EGTA block induction of hippocampal long-term potentiation

1983 • 1,106 citations

Membrane depolarization and calcium induce c-fos transcription via phosphorylation of transcription factor CREB

1990 • 1,061 citations

Requirement for BDNF in Activity-Dependent Survival of Cortical Neurons

1994 • 974 citations

Postnatal development of the visual cortex and the influence of environment

1982 • 960 citations

CREB: A Major Mediator of Neuronal Neurotrophin Responses

1997 • 936 citations

Blockade of "NMDA" Receptors Disrupts Experience-Dependent Plasticity of Kitten Striate Cortex

1987 • 920 citations

Requirement of a Critical Period of Transcription for Induction of a Late Phase of LTP

1994 • 889 citations

Regulation of brain Type II Ca2+/calmodulin-dependent protein kinase by autophosphorylation: A Ca2+-triggered molecular switch

1986 • 856 citations

Multiple promoters direct tissue-specific expression of the rat BDNF gene

1993 • 851 citations

Signaling from Synapse to Nucleus: Postsynaptic CREB Phosphorylation during Multiple Forms of Hippocampal Synaptic Plasticity

1996 • 701 citations

BDNF mRNA expression is increased in adult rat forebrain after limbic seizures: Temporal patterns of induction distinct from NGF

1991 • 699 citations

Binocular impulse blockade prevents the formation of ocular dominance columns in cat visual cortex

1986 • 694 citations

Identification of a Signaling Pathway Involved in Calcium Regulation of BDNF Expression

1998 • 687 citations

Increased levels of messenger RNAs for neurotrophic factors in the brain during kindling epileptogenesis

1991 • 636 citations

Inhibition of Ocular Dominance Column Formation by Infusion of NT-4/5 or BDNF

1995 • 572 citations

Calcium/calmodulin-dependent protein kinase types II and IV differentially regulate CREB-dependent gene expression.

1994 • 542 citations

CaMKII regulates the frequency-response function of hippocampal synapses for the production of both LTD and LTP

1995 • 530 citations

Light regulates expression of brain-derived neurotrophic factor mRNA in rat visual cortex.

1992 • 515 citations

Common Forms of Synaptic Plasticity in the Hippocampus and Neocortex in Vitro

1993 • 485 citations

Neurotrophins and Time: Different Roles for TrkB Signaling in Hippocampal Long-Term Potentiation

1997 • 482 citations

Co-regulation of long-term potentiation and experience-dependent synaptic plasticity in visual cortex by age and experience

1995 • 428 citations

CBP: A Signal-Regulated Transcriptional Coactivator Controlled by Nuclear Calcium and CaM Kinase IV

1998 • 420 citations

Potentiated Transmission and Prevention of Further LTP by Increased CaMKII activity in Postsynaptic Hippocampal Slice Neurons

1994 • 330 citations

Blockade of Endogenous Ligands of TrkB Inhibits Formation of Ocular Dominance Columns

1997 • 309 citations

Neurotrophins and activity-dependent development of the neocortex

1996 • 305 citations

Exploration of the primary visual cortex, 1955–78

1982 • 304 citations

Brain-Derived Neurotrophic Factor Enhances Long-Term Potentiation in Rat Visual Cortex

1997 • 283 citations

Control of Recruitment and Transcription-Activating Function of CBP Determines Gene Regulation by NMDA Receptors and L-Type Calcium Channels

1999 • 278 citations

Characterization of a Ca2+/Calmodulin-dependent Protein Kinase Cascade

1995 • 221 citations

Regulation of CBP-Mediated Transcription by Neuronal Calcium Signaling

1999 • 220 citations

Differential Effects of Protein Synthesis Inhibition on the Activity-Dependent Expression of BDNF Transcripts: Evidence for Immediate-Early Gene Responses from Specific Promoters

1996 • 166 citations

Monocular deprivation decreases the expression of messenger RNA for brain-derived neurotrophic factor in the rat visual cortex

1995 • 131 citations

A non‐selective cation current activated via the multifunctional Ca(2+)‐calmodulin‐dependent protein kinase in human epithelial cells.

1995 • 84 citations

Activation protein 1-dependent transcriptional activation of interleukin 2 gene by Ca2+/calmodulin kinase type IV/Gr.

1996 • 60 citations

Neurotrophins: New roles for a seasoned cast

1997 • 24 citations

Cortical development: With an eye on neurotrophins

1996 • 23 citations