A peptide segment critical for sodium channel inactivation functions as an inactivation gate in a potassium channel

A quantitative description of membrane current and its application to conduction and excitation in nerve

1952 • 21,965 citations

Rapid and efficient site-specific mutagenesis without phenotypic selection.

1985 • 7,573 citations

Biophysical and Molecular Mechanisms of Shaker Potassium Channel Inactivation

1990 • 1,528 citations

Inactivation of the sodium channel. I. Sodium current experiments.

1977 • 1,509 citations

Structural parts involved in activation and inactivation of the sodium channel

1989 • 1,189 citations

Inactivation of the sodium channel. II. Gating current experiments.

1977 • 943 citations

Interaction of Tetraethylammonium Ion Derivatives with the Potassium Channels of Giant Axons

1971 • 930 citations

A cluster of hydrophobic amino acid residues required for fast Na(+)-channel inactivation.

1992 • 810 citations

Restoration of Inactivation in Mutants of Shaker Potassium Channels by a Peptide Derived from ShB

1990 • 752 citations

Cloning of Genomic and Complementary DNA from Shaker , a Putative Potassium Channel Gene from Drosophila

1987 • 721 citations

A reinterpretation of mammalian sodium channel gating based on single channel recording

1983 • 675 citations

Inactivation of the Potassium Conductance and Related Phenomena Caused by Quaternary Ammonium Ion Injection in Squid Axons

1969 • 427 citations

Identification of an Intracellular Peptide Segment Involved in Sodium Channel Inactivation

1988 • 382 citations

A rat brain na+ channel α subunit with novel gating properties

1988 • 359 citations

Putative receptor for the cytoplasmic inactivation gate in the Shaker K+ channel

1991 • 341 citations

Multiple products of the drosophila Shaker gene may contribute to potassium channel diversity

1988 • 324 citations

The inactivation gate of the Shaker K+ channel behaves like an open-channel blocker

1991 • 308 citations

Cloning of a probable potassium channel gene from mouse brain

1988 • 304 citations

Voltage-dependent gating of Shaker A-type potassium channels in Drosophila muscle.

1990 • 276 citations

The internal quaternary ammonium receptor site of Shaker potassium channels

1993 • 273 citations

Functional expression of sodium channel mutations identified in families with periodic paralysis

1993 • 226 citations

Inhibition of inactivation of single sodium channels by a site-directed antibody.

1989 • 218 citations

A sodium channel defect in hyperkalemic periodic paralysis: Potassium-induced failure of inactivation

1991 • 213 citations

A neutral amino acid change in segment IIS4 dramatically alters the gating properties of the voltage-dependent sodium channel.

1990 • 186 citations

Potassium channels expressed from rat brain cDNA have delayed rectifier properties

1988 • 173 citations

Cloned neuronal Ik(A) channels reopen during recovery from inactivation

1991 • 157 citations

Destruction of the sodium conductance inactivation by a specific protease in perfused nerve fibres from Loligo.

1976 • 155 citations

A Family of Three Mouse Potassium Channel Genes with Intronless Coding Regions

1990 • 150 citations

Interactions of amino terminal domains of Shaker K channels with a pore blocking site studied with synthetic peptides.

1993 • 148 citations

Kinetic analysis of pancuronium interaction with sodium channels in squid axon membranes.

1977 • 144 citations

Sodium channel mutations in paramyotonia congenita and hyperkalemic periodic paralysis

1993 • 129 citations

Chapter 25 Expression of Ion Channels by Injection of mRNA into Xenopus Oocytes

1991 • 85 citations

A voltage-dependent gating transition induces use-dependent block by tetrodotoxin o rat IIA sodium channels expressed in xenopus oocytes

1991 • 74 citations

Altered gating and conductance of Na+ channels in hyperkalemic periodic paralysis

1991 • 73 citations

Arginine-specific reagents remove sodium channel inactivation

1978 • 69 citations

Swapping of functional domains in voltage-gated K ⁺ channels

1991 • 49 citations

Interaction of n-alkylguanidines with the sodium channels of squid axon membrane.

1980 • 44 citations

Interaction of nonylguanidine with the sodium channel

1980 • 18 citations

Sodium channel gene defects in the periodic paralyses

1992 • 6 citations