Transgenic mice with targeted inactivation of the Col2 alpha 1 gene for collagen II develop a skeleton with membranous and periosteal bone but no endochondral bone.

Altering the Genome by Homologous Recombination

1989 • 2,021 citations

COLLAGENS: Molecular Biology, Diseases, and Potentials for Therapy

1995 • 1,599 citations

Heritable Disorders of Connective Tissue

1960 • 1,560 citations

Mutations in the transmembrane domain of FGFR3 cause the most common genetic form of dwarfism, achondroplasia

1994 • 1,273 citations

A Constitutively Active Mutant PTH-PTHrP Receptor in Jansen-Type Metaphyseal Chondrodysplasia

1995 • 668 citations

Autosomal dominant and recessive osteochondrodysplasias associated with the COL11A2 locus

1995 • 398 citations

Bone and cartilage differentiation

1994 • 389 citations

A fibrillar collagen gene, Col11a1, is essential for skeletal morphogenesis

1995 • 370 citations

Mice lacking alpha 1 (IX) collagen develop noninflammatory degenerative joint disease.

1994 • 297 citations

Identification of cross-linking sites in bovine cartilage type IX collagen reveals an antiparallel type II-type IX molecular relationship and type IX to type IX bonding

1992 • 274 citations

Expression of the mouse α1 (II) collagen gene is not restricted to cartilage during development

1991 • 264 citations

A type X collagen mutation causes Schmid metaphyseal chondrodysplasia

1993 • 260 citations

Mouse cartilage matrix deficiency (cmd) caused by a 7 bp deletion in the aggrecan gene

1994 • 242 citations

Osteoarthritis associated with mild chondrodysplasia in transgenic mice expressing alpha 1(IX) collagen chains with a central deletion.

1993 • 188 citations

Mutations that alter the primary structure of type I collagen. The perils of a system for generating large structures by the principle of nucleated growth.

1990 • 163 citations

Immunological and biochemical studies of collagen type transition during in vitro chondrogenesis of chick limb mesodermal cells

1977 • 147 citations

Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene.

1991 • 139 citations

Type VI collagen of the intervertebral disc. Biochemical and electron-microscopic characterization of the native protein

1987 • 138 citations

The long and short of hedgehog signaling

1995 • 134 citations

Expression of a partially deleted gene of human type II procollagen (COL2A1) in transgenic mice produces a chondrodysplasia.

1991 • 132 citations

Transient expression of collagen type II at epitheliomesenchymal interfaces during morphogenesis of the cartilaginous neurocranium

1986 • 131 citations

Chondrodysplasia in transgenic mice harboring a 15-amino acid deletion in the triple helical domain of pro alpha 1(II) collagen chain.

1992 • 123 citations

The transient expression of type II collagen at tissue interfaces during mammalian craniofacial development

1991 • 114 citations

Pax: Genes for mice and men

1994 • 103 citations

Structure of cDNA clones coding for human type II procollagen. The α 1(II) chain is more similar to the α 1(I) chain than two other α chains of fibrillar collagens

1989 • 101 citations

The developmental specification of the vertebrate skull.

1988 • 97 citations

Evolutionary Consequences of Skeletal Differentiation

1975 • 84 citations

Nonexpression of cartilage type II collagen in a case of Langer-Saldino achondrogenesis.

1986 • 83 citations

An inbred line of transgenic mice expressing an internally deleted gene for type II procollagen (COL2A1). Young mice have a variable phenotype of a chondrodysplasia and older mice have osteoarthritic changes in joints.

1993 • 81 citations

Identification of col2a1 gene mutations in patients with chondrodysplasias and familial osteoarthritis

1995 • 69 citations

Calcium deficiency induces expression of cartilage-like phenotype in chick embryonic calvaria

1986 • 62 citations

Concentration of mutations causing schmid metaphyseal chondrodysplasia in the C-terminal noncollagenous domain of type X collagen

1995 • 54 citations

Interactive Cellular Modulation of Chondrogenic Differentiation in Vitro by Subpopulations of Chick Embryonic Calvarial Cells

1995 • 48 citations

Efficiency of insertion versus replacement vector targeting varies at different chromosomal loci.

1994 • 38 citations

The complete cDNA coding sequence for the mouse proα1(I) chain of type I procollagen

1995 • 27 citations