Ca2+-dependent phosphorylation of tyrosine hydroxylase in PC12 cells.

A Rapid and Sensitive Method for the Quantitation of Microgram Quantities of Protein Utilizing the Principle of Protein-Dye Binding

1976 • 225,752 citations

High resolution two-dimensional electrophoresis of proteins.

1975 • 19,515 citations

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor.

1976 • 5,526 citations

Radioimmunoassay for Cyclic Nucleotides

1972 • 2,057 citations

Microtubule Assembly in the Absence of Added Nucleotides

1973 • 2,055 citations

Refinement of the Coomassie blue method of protein quantitation

1978 • 1,573 citations

High resolution two-dimensional electrophoresis of human plasma proteins.

1977 • 659 citations

Radioimmunoassay of cyclic AMP and cyclic GMP.

1979 • 553 citations

Purification and characterization of a calmodulin-dependent protein kinase that is highly concentrated in brain.

1983 • 481 citations

Discovery of A Ca²⁺‐and calmodulin‐dependent protein phosphatase

1982 • 476 citations

Purification of cyclic 3',5'-nucleotide phosphodiesterase inhibitory protein by affinity chromatography on activator protein coupled to sepharose

1978 • 463 citations

Solubilization and Partial Purification of Tyrosine Hydroxylase from Bovine Adrenal Medulla

1971 • 412 citations

Ca2+-dependent protein phosphorylation system in membranes from various tissues, and its activation by "calcium-dependent regulator".

1978 • 346 citations

Stimulation of Ca ²⁺ -dependent neurotransmitter release and presynaptic nerve terminal protein phosphorylation by calmodulin and a calmodulin-like protein isolated from synaptic vesicles

1979 • 346 citations

Purification and characterization of a calmodulin-dependent kinase from rat brain cytosol able to phosphorylate tubulin and microtubule-associated proteins.

1983 • 343 citations

Stimulation of brain membrane protein phosphorylation by calcium and an endogenous heat-stable protein

1978 • 332 citations

Nerve growth factor mediates phosphorylation of specific proteins

1980 • 305 citations

Direct phosphorylation of brain tyrosine hydroxylase by cyclic AMP-dependent protein kinase: mechanism of enzyme activation.

1978 • 286 citations

Purification and Cahracyterization of te Brain Calmodulin‐Dependent Protein Kinase (Kinase II), Which Is involved in the Activtion of Tryptophan 5‐Monooxygnase

1983 • 245 citations

Purification and Characterization of a Ca²⁺‐ and Calmodulin‐Dependent Protein Kinase from Rat Brain

1982 • 235 citations

A new activator protein that activates tryptophan 5-monooxygenase and tyrosine 3-monooxygenase in the presence of Ca2+-, calmodulin-dependent protein kinase. Purification and characterization.

1981 • 234 citations

Phosphorylation of microtubule-associated proteins by a Ca2+/calmodulin-dependent protein kinase.

1984 • 213 citations

Tyrosine hydroxylase: a substrate of cyclic AMP-dependent protein kinase.

1980 • 189 citations

Multiple forms of the nerve growth factor protein and its subunits

1968 • 179 citations

Evidence for involvement of protein kinase in the activation by adenosine 3':5'-monophosphate of brain tyrosine 3-monooxygenase.

1975 • 179 citations

Phosphorylation and activation of tyrosine hydroxylase mediate the cAMP-induced increase in catecholamine biosynthesis in adrenal chromaffin cells.

1982 • 177 citations

Purification and characterization of a rabbit liver calmodulin-dependent protein kinase able to phosphorylate glycogen synthase.

1982 • 176 citations

Distinct patterns of cytoplasmic protein phosphorylation related to regulation of synthesis and release of prolactin by GH cells.

1983 • 172 citations

Purification and characterization of rabbit liver calmodulin-dependent glycogen synthase kinase.

1983 • 152 citations

Phosphorylation of tyrosine hydroxylase by calmodulin-dependent multiprotein kinase.

1984 • 152 citations

Purification and characterization of calcium/calmodulin-dependent protein kinase from rat brain

1984 • 147 citations

The calmodulin‐dependent glycogen synthase kinase from rabbit skeletal muscle

1983 • 147 citations

Release of [3H]norepinephrine from a clonal line of pheochromocytoma cells (PC12) by nicotinic cholinergic stimulation

1977 • 141 citations

Tyrosine hydroxylase activation in depolarized dopaminergic terminals—involvement of Ca2+ -dependent phosphorylation

1983 • 140 citations

A multifunctional calmodulin‐dependent protein kinase

1983 • 134 citations

Calcium antagonists High-affinity binding and inhibition of calcium transport in a clonal cell line.

1982 • 125 citations

Thyrotropin-releasing hormone rapidly and transiently stimulates cytosolic calcium-dependent protein phosphorylation in GH3 pituitary cells.

1982 • 102 citations

Multiple site phosphorylation of tyrosine hydroxylase. Differential regulation in situ by a 8-bromo-cAMP and acetylcholine.

1982 • 100 citations

Calmodulin-stimulated protein kinase activity from rat pancreas.

1983 • 92 citations

SHORT‐TERM REGULATION OF CATECHOLAMINE BIOSYNTHESIS IN A NERVE GROWTH FACTOR RESPONSIVE CLONAL LINE OF RAT PHEOCHROMOCYTOMA CELLS

1978 • 79 citations

Depolarising effect of curare on embryonic rat muscles

1978 • 77 citations

A patch‐clamp study of the partial agonist actions of tubocurarine on rat myotubes.

1984 • 70 citations

A New Activator Protein That Activates Tryptophan 5-Monooxygenase and Tyrosine 3-Monooxygenase in the Presence of Ca2+-, Calmodulin- dependent Protein Kinase

1981 • 65 citations

Tyrosine hydroxylase: studies on the phosphorylation of a purified preparation of the brain enzyme by the cyclic AMP-dependent protein kinase.

1981 • 61 citations

Hormone-induced protein phosphorylation. I. Relationship between secretagogue action and endogenous protein phosphorylation in intact cells from the exocrine pancreas and parotid.

1982 • 56 citations

Relationship between activation and phosphorylation of tyrosine hydroxylase by 56 mm K+ in PC12 cells in culture.

1984 • 54 citations

Hormone-induced protein phosphorylation. II. Localization to the ribosomal fraction from rat exocrine pancreas and parotid of a 29,000-dalton protein phosphorylated in situ in response to secretagogues.

1982 • 52 citations

Differential phosphorylation of MAP-2 stimulated by calcium-calmodulin and cyclic AMP.

1984 • 44 citations

Regulation of catecholamine biosynthesis in a transplantable rat pheochromocytoma.

1977 • 41 citations

Calcium-Dependent Protein Phosphorylation

1982 • 40 citations

Stimulation of synaptosomal dopamine synthesis by veratridine

1974 • 33 citations

Brain striatal tyrosine hydroxylase: activation of the enzyme by cyclic AMP-independent phosphorylation.

1979 • 26 citations

Brain striatal tyrosine hydroxylase: activation of the enzyme by cyclic AMP-independent phosphorylation.

1979 • 22 citations

Protein phosphorylation system in bovine brain cytosol dependent on calcium and calmodulin

1982 • 12 citations

Differential Phosphorylation of MAP-2 Stimulated by Calcium-Calmodulin and Cyclic AMP

1984 • 8 citations