Characterization of ligand-binding systems by continuous affinity distributions of arbitrary shape

THE ATTRACTIONS OF PROTEINS FOR SMALL MOLECULES AND IONS

1949 • 19,979 citations

Viscoelastic Properties of Polymers

1961 • 13,533 citations

On the Structure of a Catalyst Surface

1948 • 3,259 citations

Endogenous opioid peptides: multiple agonists and receptors

1977 • 2,494 citations

Smoothing by spline functions

1967 • 2,217 citations

Variations in Affinities of Antibodies during the Immune Response^*

1964 • 1,078 citations

Properties of graphical representations of multiple classes of binding sites

1971 • 616 citations

On the Structure of a Catalyst Surface. II

1950 • 381 citations

Physical Chemistry of Protein Solutions. IV. The Combination of Human Serum Albumin with Chloride Ion¹

1950 • 368 citations

Heterogeneity and Average Combining Constants of Antibodies from Individual Rabbits

1958 • 312 citations

Viscoelastic Properties of Polymers.

1961 • 302 citations

Immunologic Specificity and Molecular Structure

1963 • 301 citations

An Introduction to Transform Theory

1971 • 288 citations

Mathematics of Hormone-Receptor Interaction

1973 • 226 citations

Some approximate equations useful in the phenomenological treatment of linear viscoelastic data

1959 • 204 citations

THE PRECIPITIN REACTION BETWEEN TYPE III PNEUMOCOCCUS POLYSACCHARIDE AND HOMOLOGOUS ANTIBODY

1935 • 200 citations

The Adsorption of Hydrogen on Tungsten Powders

1947 • 184 citations

The Serological Properties of Simple Substances. VII. A Quantitative Theory of the Inhibition by Haptens of the Precipitation of Heterogeneous Antisera with Antigens, and Comparison with Experimental Results for Polyhaptenic Simple Substances and for Azoproteins

1944 • 175 citations

The Interaction of Purified Antibody with Optically Isomeric Haptens^1,2

1956 • 168 citations

Distribution of antibody affinities: Technique of measurement

1972 • 167 citations

Heterogeneity of estrogen receptors in the cytosol and nuclear fractions of the rat uterus

1978 • 156 citations

Higher approximation methods for the relaxation spectrum from static and dynamic measurements of visco-elastic materials

1953 • 141 citations

Protein interactions with small molecules

1974 • 139 citations

Two techniques for evaluating small molecule-macromolecule binding in complex system

1975 • 133 citations

Properties of gamma-aminobutyric acid receptor binding with (+)-[3H]bicuculline methiodide in rat cerebellum.

1978 • 93 citations

Heterogeneity of cerebral β-adrenoceptor binding sites in various vertebrate species

1978 • 82 citations

Opioid peptides and opiates differ in receptor selectivity

1977 • 71 citations

Skeletal muscle acetylcholine receptor. Purification, characterization, and turnover in muscle cell cultures.

1978 • 67 citations

Macromolecule-small molecule interactions: Analytical and graphical reexamination

1971 • 55 citations

Heterogeneity of Antibody Sites in Their Relative Combining Affinities for Structurally Related Haptens

1958 • 54 citations

Antigen Antibody Interactions

1976 • 46 citations

Computer modeling of several ligands binding to multiple receptors.

1979 • 42 citations

Derivation of antibody distribution from experimental binding data

1976 • 37 citations

CHEMICAL AND STRUCTURAL DIFFERENCES BETWEEN ANTIBODIES CAPABLE OF BINDING A PARTICULAR HAPTEN GROUP: EVIDENCE FOR LIMITED HETEROGENEITY *

1970 • 34 citations

ADSORBENT-ADSORBATE INTERACTIONS AND SURFACE HETEROGENEITY IN PHYSICAL ADSORPTION

1954 • 33 citations

A method for the determination of heterogeneity of antibodies

1963 • 31 citations

QUANTITATIVE VARIATIONS IN L CHAIN TYPES IN GUINEA PIG ANTIHAPTEN ANTIBODIES

1966 • 28 citations

Graphical aids to interpretation of scatchard plots and dose-response curves

1979 • 25 citations

Determination of total affinity constant for heterogeneous hapten-antibody interactions

1974 • 21 citations

Theory of hapten binding to IgM: The question of repulsive interactions between binding sites

1975 • 21 citations

Separation of antibodies into fractions with different binding properties

1967 • 20 citations

Theory of ligand binding to heterogeneous receptor populations: Characterization of the free‐energy distribution function

1978 • 20 citations

Higher Approximation to Relaxation Spectra from Dynamic Measurements

1958 • 19 citations

Analysis of Multilayer Gas Adsorption Isotherms Using the Concept of Surface Heterogeneity

1953 • 17 citations

Approximations in Linear Viscoelasticity Theory: Delta Function Approximations

1954 • 16 citations

The heterogeneity of antibodies with respect to equilibrium constants

1976 • 15 citations

Limited heterogeneity of antibodies resolution of hapten binding curves into linear components

1972 • 14 citations

The characterization of heterogeneous antibody-hapten interactions using non-linear regression analysis on fluorescence quenching curves

1978 • 12 citations

Heterogeneity of steroid hormone receptor in adult rat lung cytosol

1977 • 8 citations

Characterization of receptor affinity heterogeneity by scatchard plots

1978 • 7 citations

Heterogeneous insulin- and concanavalin A-binding among spleen lymphocytes established by affinity chromatography

1977 • 7 citations

A new method to characterize saturation functions by their first four moments

1978 • 4 citations

An analysis of the limits of resolution of binding experiments as assays for affinity heterogeneity

1978 • 3 citations