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[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

Crystallography & NMR System: A New Software Suite for Macromolecular Structure Determination

1998 • 15,791 citations

On the nature of allosteric transitions: A plausible model

1965 • 8,699 citations

AMoRe: an automated package for molecular replacement

1994 • 4,990 citations

Glutamate receptor ion channels

2005 • 3,667 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Comparison of Experimental Binding Data and Theoretical Models in Proteins Containing Subunits^*

1966 • 2,956 citations

Application of a Theory of Enzyme Specificity to Protein Synthesis

1958 • 2,272 citations

Ion Channels/Excitable Membranes

2006 • 2,013 citations

A Family of AMPA-Selective Glutamate Receptors

1990 • 1,453 citations

Subunit stoichiometry of a mammalian K+ channel determined by construction of multimeric cDNAs

1992 • 1,067 citations

Molecular Cloning and Functional Expression of Glutamate Receptor Subunit Genes

1990 • 925 citations

Emerging structure of the Nicotinic Acetylcholine receptors

2002 • 896 citations

Mechanisms for Activation and Antagonism of an AMPA-Sensitive Glutamate Receptor

2000 • 870 citations

Structure of a glutamate-receptor ligand-binding core in complex with kainate

1998 • 672 citations

Mechanism of glutamate receptor desensitization

2002 • 650 citations

Selective modulation of desensitization at AMPA versus kainate receptors by cyclothiazide and concanavalin A

1993 • 581 citations

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1993 • 440 citations

Hippocampal neurons exhibit cyclothiazide-sensitive rapidly desensitizing responses to kainate

1993 • 369 citations

The structure and function of glutamate receptor ion channels

2002 • 366 citations

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1998 • 236 citations

Molecular mechanism for ligand discrimination of cyclic nucleotide-gated channels

1995 • 183 citations

Structural Basis for AMPA Receptor Activation and Ligand Selectivity: Crystal Structures of Five Agonist Complexes with the GluR2 Ligand-binding Core

2002 • 158 citations

Mechanisms for ligand binding to GluR0 ion channels: crystal structures of the glutamate and serine complexes and a closed apo state

2001 • 145 citations

Agonist-induced Isomerization in a Glutamate Receptor Ligand-binding Domain

2000 • 110 citations

Mechanism of Activation and Selectivity in a Ligand-Gated Ion Channel: Structural and Functional Studies of GluR2 and Quisqualate^,

2002 • 107 citations

A Venus Flytrap Mechanism for Activation and Desensitization of α-Amino-3-hydroxy-5-methyl-4-isoxazole Propionic Acid Receptors

1996 • 92 citations

Probing the ligand binding domain of the GluR2 receptor by proteolysis and deletion mutagenesis defines domain boundaries and yields a crystallizable construct

1998 • 82 citations

Probing the Function, Conformational Plasticity, and Dimer−Dimer Contacts of the GluR2 Ligand-Binding Core: Studies of 5-Substituted Willardiines and GluR2 S1S2 in the Crystal^,

2003 • 81 citations

Cyclic nucleotide-gated channels: structural basis of ligand efficacy and allosteric modulation

1997 • 44 citations

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2001 • 28 citations

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2000 • 2 citations