Substrate-dependent regulation of intracellular amino acid concentrations in cultured bovine aortic endothelial cells

The obligatory role of endothelial cells in the relaxation of arterial smooth muscle by acetylcholine

1980 • 12,033 citations

Vascular endothelial cells synthesize nitric oxide from L-arginine

1988 • 4,800 citations

L-arginine is the physiological precursor for the formation of nitric oxide in endothelium-dependent relaxation

1988 • 1,379 citations

Biosynthesis of nitric oxide from l-arginine

1989 • 1,220 citations

Endothelium-derived relaxing factor from pulmonary artery and vein possesses pharmacologic and chemical properties identical to those of nitric oxide radical.

1987 • 1,182 citations

A specific inhibitor of nitric oxide formation from <scp>l</scp>‐arginine attenuates endothelium‐dependent relaxation

1989 • 862 citations

The regulation of amino acid transport in animal cells

1978 • 467 citations

The regulation of neutral amino acid transport in mammalian cells

1983 • 459 citations

Arginine is a physiological precursor of endothelium-derived nitric oxide

1988 • 392 citations

Rapid assay for amino acids in serum or urine by pre-column derivatization and reversed-phase liquid chromatography.

1982 • 368 citations

The transport of cationic amino acids across the plasma membrane of mammalian cells

1985 • 287 citations

Endothelial cells metabolize NG -monomethyl-L-arginine to L-citrulline and subsequently to L-arginine

1990 • 185 citations

L-arginine availability determines the duration of acetylcholine-induced systemic vasodilatation in vivo

1989 • 126 citations

Depletion of arterial L-arginine causes reversible tolerance to endothelium-dependent relaxation

1989 • 126 citations

Adaptive regulation of amino acid transport in cultured human fibroblasts. Sites and mechanism of action.

1981 • 120 citations

Relationship of the pool of intracellular valine to protein synthesis and degradation in cultured cells.

1976 • 95 citations

Cultured endothelial cells maintain their L-arginine level despite the continuous release of EDRF

1990 • 89 citations

Effect of amino acid deprivation on initiation of protein synthesis in rat hepatocytes

1989 • 88 citations

Endothelial nitric oxide generating enzyme(s) in the bovine aorta: subcellular location and metabolic characterization.

1990 • 67 citations

The generation of L-arginine in endothelial cells is linked to the release of endothelium-derived relaxing factor

1990 • 55 citations

Expression of amino acid transport systems in cultured human umbilical vein endothelial cells.

1989 • 52 citations

Oxidized polyamines and the growth of human vascular endothelial cells. Prevention of cytotoxic effects by selective acetylation

1987 • 47 citations

Vascular activity of polycations and basic amino acids: L-arginine does not specifically elicit endothelium-dependent relaxation

1989 • 45 citations

Inhibition by <scp>l</scp>‐glutamine of the release of endothelium‐derived relaxing factor from cultured endothelial cells

1990 • 44 citations

A simple DNA-dependent fluorescence enhancement assay for cell number.

1981 • 38 citations

Endothelial cell subpopulations in vitro: cell volume, cell cycle, and radiosensitivity

1989 • 37 citations

Substrate-dependent adaptive regulation and trans-inhibition of system A-mediated amino acid transport. Studies using rat hepatoma plasma membrane vesicles

1990 • 31 citations

Fasting, Refeeding and Diabetes Modulate Free Amino Acid Concentrations in the Rat Exocrine Pancreas

1988 • 18 citations

Stimulation of protein synthesis by lysine analogues in lysine-deprived Ehrlich ascites tumour cells

1984 • 3 citations