Potent and Selective Non-Cysteine-Containing Inhibitors of Protein Farnesyltransferase

Palladium-Catalyzed Cross-Coupling Reactions of Organoboron Compounds

1995 • 12,149 citations

ras GENES

1987 • 3,818 citations

All ras proteins are polyisoprenylated but only some are palmitoylated

1989 • 1,806 citations

Oxidation of long-chain and related alcohols to carbonyls by dimethyl sulfoxide "activated" by oxalyl chloride

1978 • 1,616 citations

p21ras is modified by a farnesyl isoprenoid.

1989 • 847 citations

p-Alkoxybenzyl Alcohol Resin and p-Alkoxybenzyloxycarbonylhydrazide Resin for Solid Phase Synthesis of Protected Peptide Fragments

1973 • 775 citations

Benzodiazepine Peptidomimetics: Potent Inhibitors of Ras Farnesylation In Animal Cells

1993 • 631 citations

Farnesyltransferase inhibitors: Ras research yields a potential cancer therapeutic

1994 • 523 citations

PROTEIN PRENYLATION: GENES, ENZYMES, TARGETS, AND FUNCTIONS

1992 • 380 citations

The Conversion of Phenols to Thiophenols via Dialkylthiocarbamates¹

1966 • 345 citations

THE POTENTIAL OF FARNESYLTRANSFERASE INHIBITORS AS CANCER CHEMOTHERAPEUTICS

1997 • 329 citations

Protein farnesyltransferase inhibitors block the growth of ras-dependent tumors in nude mice.

1994 • 287 citations

Pseudopeptide Inhibitors of Ras Farnesyl-Protein Transferase

1994 • 109 citations

Development of Highly Potent Inhibitors of Ras Farnesyltransferase Possessing Cellular andin VivoActivity

1996 • 87 citations

Design and Synthesis of Non-Peptide Ras CAAX Mimetics as Potent Farnesyltransferase Inhibitors

1996 • 74 citations

Structure−Activity Relationship of 3-Substituted N-(Pyridinylacetyl)-4- (8-chloro-5,6-dihydro-11H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)- piperidine Inhibitors of Farnesyl-Protein Transferase: Design and Synthesis of in Vivo Active Antitumor Compounds

1997 • 50 citations

New approaches to anticancer drug design based on the inhibition of farnesyltransferase

1998 • 37 citations

Pseudodipeptide Inhibitors of Protein Farnesyltransferase

1995 • 32 citations

Inhibitors of Farnesyl Protein Transferase. 4-Amido, 4-Carbamoyl, and 4-Carboxamido Derivatives of 1-(8-Chloro-6,11-dihydro-5H-benzo[5,6]- cyclohepta[1,2-b]pyridin-11-yl)piperazine and 1-(3-Bromo-8-chloro-6,11- dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-yl)piperazine

1998 • 28 citations

Novel Conformationally Extended Naphthalene-Based Inhibitors of Farnesyltransferase

1997 • 26 citations

Section Review Oncologic, Endocrine & Metabolic: Farnesyl-protein transferase inhibitors in early development

1996 • 9 citations

Glycine receptors

1997 • 1 citations