Is there a role for a pure noradrenergic drug in the treatment of depression?

Serotonin Function and the Mechanism of Antidepressant Action

1990 • 911 citations

Fluoxetine and suicide: a meta-analysis of controlled trials of treatment for depression.

1991 • 367 citations

Catecholamine Metabolism, Depressive Illness, and Drug Response

1972 • 341 citations

A Preliminary, Open Study of the Combination of Fluoxetine and Desipramine for Rapid Treatment of Major Depression

1991 • 303 citations

A double-blind comparison of venlafaxine and fluoxetine in patients hospitalized for major depression and melancholia

1994 • 301 citations

Antidepressant Response to Tricyclics and Urinary MHPG in Unipolar Patients

1975 • 269 citations

Catecholamine metabolism in affective disorders—III

1970 • 239 citations

The Prophylactic Efficacy of Fluoxetine in Unipolar Depression

1988 • 234 citations

3-Methoxy-4-Hydroxy Phenylglycol (MHPG) Excretion in Depressive States

1968 • 208 citations

Clinical and Biochemical Effects of Catecholamine Depletion on Antidepressant-Induced Remission of Depression

1996 • 193 citations

Rapid serotonin depletion as a provocative challenge test for patients with major depression: relevance to antidepressant action and the neurobiology of depression.

1991 • 191 citations

Paroxetine is better than placebo in relapse prevention and the prophylaxis of recurrent depression

1993 • 190 citations

Antidepressant Drugs and the Emergence of Suicidal Tendencies

1993 • 167 citations

Monoamines and the mechanism of antidepressant action: effects of catecholamine depletion on mood of patients treated with antidepressants.

1993 • 158 citations

Toward a biochemical classification of depressive disorders

1981 • 132 citations

Urinary Catecholamine Metabolites during Behavioral Changes in a Patient with Manic-Depressive Cycles

1973 • 118 citations

Daily variations of the urine content of 3-methoxy-4-hydroxyphenylglycol in two manic-depressive patients

1972 • 116 citations

Rapid down regulation of β-adrenoceptors by co-administration of desipramine and fluoxetine

1988 • 113 citations

Reduction of suicidal thoughts with paroxetine in comparison with reference antidepressants and placebo

1995 • 109 citations

Pretreatment neurotransmitter metabolite levels and response to tricyclic antidepressant drugs

1984 • 87 citations

Urinary 4-hydroxy-3-methoxyphenylglycol is not a predictor for clinical response to amitriptyline in depressive illness

1979 • 76 citations

Treatment strategy in depression

1988 • 76 citations

Urinary MHPG Levels and Tricyclic Antidepressant Drug Selection

1979 • 70 citations

Effects of zimelidine and desipramine on serotonin and noradrenaline uptake mechanisms in relation to plasma concentrations and to therapeutic effects during treatment of depression

1981 • 58 citations

Noradrenaline in basic models of depression

1997 • 56 citations

THE IDENTIFICATION OF DEPRESSED PATIENTS WHO HAVE A DISORDER OF NE METABOLISM AND/OR DISPOSITION

1973 • 45 citations

Catecholamine metabolism in affective disorders —IV. Preliminary studies of norepinephrine metabolism in depressed patients treated with amitriptyline

1972 • 43 citations

Controlled cross-over study of a 5-HT uptake inhibiting and an NA uptake inhibiting antidepressant.

1981 • 37 citations

Controlled cross‐over study of a 5‐HT uptake inhibiting and an NA uptake inhibiting antidepressant

1981 • 32 citations

Response to Amitriptyline and Urinary MHPG in Bipolar Depressive Patients

1979 • 29 citations

The identification of depressed patients who have a disorder of NE metabolism and/or disposition

1973 • 18 citations

Comparing SSRIs: From chemistry to clinical choice

1995 • 14 citations

Do urinary MHPG and plasma drug levels correlate with response to amitriptyline therapy?

1982 • 13 citations

Pharmacological Specificity Is Not the Same as Clinical Selectivity

1987 • 11 citations

3‐MHPG as a non‐predictor of antidepressant response to imipramine and electroconvulsive therapy

1986 • 10 citations

MHPG, Amitriptyline and Depression: A Collaborative Study

1977 • 7 citations

Failure to correlate urinary MHPG with clinical response to amitriptyline

1984 • 6 citations