The active site of Serratia endonuclease contains a conserved magnesium-water cluster

PROCHECK: a program to check the stereochemical quality of protein structures

1993 • 23,689 citations

MOLSCRIPT: a program to produce both detailed and schematic plots of protein structures

1991 • 14,222 citations

Improved methods for building protein models in electron density maps and the location of errors in these models

1991 • 12,831 citations

The protein data bank: A computer-based archival file for macromolecular structures

1977 • 8,627 citations

SCOP: A structural classification of proteins database for the investigation of sequences and structures

1995 • 6,372 citations

Free R value: a novel statistical quantity for assessing the accuracy of crystal structures

1992 • 3,863 citations

X-PLOR Version 3.1: A System for X-ray Crystallography and NMR

1992 • 3,488 citations

Data for biochemical research

1987 • 3,056 citations

Raster3D Version 2.0. A program for photorealistic molecular graphics

1994 • 2,515 citations

Accurate bond and angle parameters for X-ray protein structure refinement

1991 • 2,467 citations

Evaluation of single-crystal X-ray diffraction data from a position-sensitive detector

1988 • 1,516 citations

Structural basis for the 3′-5′ exonuclease activity of Escherichia coli DNA polymerase I: a two metal ion mechanism.

1991 • 1,059 citations

Protein Data Bank

1984 • 731 citations

Untitled

1995 • 545 citations

Slow-cooling protocols for crystallographic refinement by simulated annealing

1990 • 530 citations

Structural Aspects of Metal Liganding to Functional Groups in Proteins

1991 • 454 citations

Metal Activation of Enzymes in Nucleic Acid Biochemistry

1998 • 403 citations

Crystal orientation and X-ray pattern prediction routines for area-detector diffractometer systems in macromolecular crystallography

1987 • 396 citations

Structure and function of the multifunctional DNA-repair enzyme exonuclease III

1995 • 382 citations

The structure of unliganded reverse transcriptase from the human immunodeficiency virus type 1.

1995 • 368 citations

Protein Hydration Observed by X-ray Diffraction

1994 • 343 citations

[27] Detecting folding motifs and similarities in protein structures

1997 • 317 citations

Computing in Crystallography

1981 • 303 citations

Calcium-Binding Sites in Proteins: A Structural Perspective

1991 • 247 citations

DNA binding and cleavage by the nuclear intron-encoded homing endonuclease I-PpoI

1998 • 237 citations

Toroidal Structure of λ-Exonuclease

1997 • 232 citations

Primers for Mitochondrial DNA Replication Generated by Endonuclease G

1993 • 230 citations

Mg2+ Binding to the Active Site of EcoRV Endonuclease: A Crystallographic Study of Complexes with Substrate and Product DNA at 2-.ANG. Resolution

1995 • 222 citations

DNase I-induced DNA conformation

1991 • 187 citations

Structure of Bacteriophage T4 RNase H, a 5′ to 3′ RNA–DNA and DNA–DNA Exonuclease with Sequence Similarity to the RAD2 Family of Eukaryotic Proteins

1996 • 178 citations

A Structural Basis for Metal Ion Mutagenicity and Nucleotide Selectivity in Human DNA Polymerase β^,

1996 • 158 citations

The role of metals in catalysis by the restriction endonuclease BamHI

1998 • 156 citations

Efficient Rebuilding of Protein Structures

1996 • 148 citations

Genetic and structural characterization of endA

1990 • 136 citations

Crystal structure of Escherichia coli RNase HI in complex with Mg²⁺ at 2.8 Å resolution: Proof for a single Mg²⁺‐binding site

1993 • 135 citations

Substrate-assisted catalysis in the cleavage of DNA by the EcoRI and EcoRV restriction enzymes.

1993 • 118 citations

An Extracellular Nuclease from Serratia marcescens

1969 • 102 citations

The extracellular nuclease gene of Serratia marcescens and its secretion from Escherichia coli

1987 • 99 citations

2.1 Å structure of Serratia endonuclease suggests a mechanism for binding to double-stranded DNA

1994 • 97 citations

Analysis of the Mechanism of the Serratia Nuclease Using Site-Directed Mutagenesis

1996 • 94 citations

ISOLATION AND PROPERTIES OF AN EXOCELLULAR NUCLEASE OF SERRATIA MARCESCENS

1963 • 94 citations

Chromosomal localization of mitochondrial transcription factor A (TCF6), single-stranded DNA-binding protein (SSBP), and Endonuclease G (ENDOG), three human housekeeping genes involved in mitochondrial biogenesis

1995 • 93 citations

Serratia marcescensand its extracellular nuclease

1998 • 91 citations

Sequence and expression ofNUC1, the gene encoding the mitochondrial nuclease inSaccharomyces cerevisiae

1988 • 83 citations

X-ray crystal analysis of the substrates of aconitase. V. Magnesium citrate decahydrate [Mg(H₂O)₆][MgC₆H₅O₇(H₂O)]₂.2H₂O

1965 • 77 citations

Identification, genetic analysis and characterization of a sugar‐non‐specific nuclease from the cyanobacterium Anabaena sp. PCC 7120

1992 • 67 citations

An Extracellular Nuclease from Serratia marcescens

1969 • 66 citations

A similar active site for non-specific and specific endonucleases.

1999 • 64 citations

Identification of catalytically relevant amino acids of the extracellularSerratia marcescensendonuclease by alignment-guided mutagenesis

1994 • 63 citations

Identification of the Serratia endonuclease dimer: Structural basis and implications for catalysis

1996 • 54 citations

Sequence preferences in cleavage of dsDNA and ssDNA by the extracellular Serratia marcescens endonuclease

1995 • 52 citations

Biochemical characterization of Anabaena sp. strain PCC 7120 non‐specific nuclease NucA and its inhibitor NuiA

1998 • 50 citations

Kinetic Analysis of the Cleavage of Natural and Synthetic Substrates by the Serratia Nuclease

1996 • 48 citations

Cleavage experiments with deoxythymidine 3′,5′‐bis‐(p‐nitrophenyl phosphate) suggest that the homing endonuclease I‐PpoI follows the same mechanism of phosphodiester bond hydrolysis as the non‐specific Serratia nuclease¹

1999 • 35 citations

A Procedure for Renaturation and Purification of the Extracellular Serratia marcescens Nuclease from Genetically Engineered Escherichia coli

1994 • 35 citations

Characterization and Expression of the MouseEndonuclease GGene

1997 • 30 citations

Analysis of the reaction mechanism of the non‐specific endonuclease of Serratia marcescens using an artificial minimal substrate

1996 • 29 citations

Three‐dimensional structure of Serratiamarcescens nuclease at 1.7 Å resolution and mechanism of its action

1997 • 28 citations

Deoxyribonuclease of Syncephalastrum racemosum - Enzymatic Properties and Molecular Structure

1993 • 28 citations

Streptococcus pyogenes

2024 • 26 citations

Endo‐exonucleases: Enzymes involved in DNA repair and cell death?

1994 • 23 citations

Genetic engineering, production and characterisation of monomeric variants of the dimeric Serratia marcescens endonuclease

1998 • 22 citations

Magnesium activation of nuclease enzymes—the importance of water

1998 • 21 citations

Nuclease structure and catalytic function

1992 • 20 citations

Nuclease structure and catalytic function

1992 • 11 citations

Synthesis and Biochemical Characterization of Obligatory Dimers of the Sugar Non-Specific Nuclease from Serratia marcescens Using Specifically Designed Bismaleimidoalkanes as SH-Specific Crosslinking Reagents

1999 • 9 citations

[Isolation and physico-chemical properties of homogenous nuclease from Serratia marcescens].

1980 • 8 citations